Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"lung cells"”.
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Bioactivation of diacetyldapsone in cultured lung cells
… the prodrug diacetyldapsone (DADDS) into the lung, which may be hydrolyzed to monoacetyldapsone and the active metabolite dapsone. The purpose of this investigation was to determine the effect of cyclodextrindiacetyldapsone (CD-DADDS) complex upon the cultured lung cells and whether or not …
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Host response of lung cells to virulent Bacillus anthracis
… virulent B. anthracis spores/vegetative cells via a robust oxidative burst. However, ~23% of dormant spores remained viable at 24h post-infection. The “persistence” of some spores may allow them to hide long enough to avoid the first wave of the immune response and germinate later. …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… to estimate regional dosimetry under direct-to-lung (DTL) and mouth-to-lung (MTL) vaping regimens. DTL produced higher overall deposition, particularly in distal lung regions, while MTL led to greater deposition in the upper airways. These differences reflected DTL’s higher flow rates and larger …
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Electronic Cigarette Exposure: Inflammatory and Immunological Implications in Structural Lung Cells and the Potential Public Health Consequences
… and non-COPD primary human airway smooth muscle cells. In this study we confirmed earlier suspicions on cytotoxicity and provided the first evidence that COPD cells are hyper-responsive to E-cigarettes. In Chapter 5 we provided the first evidence that E-cigarettes have the potential to induce …
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Evaluation of small extracellular vesicular microRNAs as biomarkersfor exposure of nicotine and E-liquids on human lung cells
… and E-Cigarette or vaping product use-associated lung injury (EVALI) can cause pulmonary disease with damaging health effects. In this study, we explored miRNAs from small extracellular vesicles (sEVs) for nicotine and E-liquid-associated biomarkers. We investigated miRNAs using NGS and further …
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Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix
… days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures …
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An Exploratory Study of the Effects of BIS-Substituted Triazolium Bromide Salts on the Proliferation of WI-38 Lung Cells and H-1299 Lung Cancer Cells
<p>Lung cancer is the leading cause of cancer deaths worldwide. The battle against this disease continues to challenge physicians and scientists daily, due to its various forms, treatments, and responses. Depending on the grade and stage of the disease, treatments can be extensive, encompassing …
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Development of a Smoke Exposure System for Organ-on-Chip Applications
… be used to test the health effects of vaping on lung cells cultured within an Organ-on-Chip device, with the goal of providing a platform that is capable of accurately and replicably exposing lung cells to vapour from vapes. Organ-on-Chip devices are an emerging technology that allow for the …
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Oxygen toxicity and radiation injury to the pulmonary system / by Geoffrey McLennan.
… radical related inflammation in the peripheral lung and in lung cells. Animal and human studies have been used. Methods include cell culture with function studies, protein chemistry, animal and human physiology, and cell and lung structure through histopathology, and various forms of electron …
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Electrohydrodynamic Atomization for Improved Macromolecular Drug Delivery
… left of the resulting droplets would affect lung cells. An <em>in vitro</em> experiment was conducted to spray aerosolized DNA, by way of EHDA, onto human derived lungs cells to test for immunogenic and toxic effects. The lung cells displayed no immunogenic or toxic response to the DNA or …
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The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration
… is known regarding the role of BMPs in adult lungs during health and disease. In the present study, the role of BMP signalling in lung cancer and lung regeneration processes was examined. Early lung cancer tumours were isolated by laser capture microdissection from Kras G12D mouse lungs and …
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Mechanisms of Emerging RNA Virus Adaptation to Hosts
… viruses in human ACE2 (hACE2)-expressing cells and decreased replication in human lung cells through reduced hACE2 binding. Next, serial passaging of SARS-CoV-2 in cells expressing the animal ACE2 receptor identified the recurring mutation A222V in the Spike gene. Spike A222V enhanced …
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The association of bovine parvovirus DNA and proteins with the nuclear matrix of infected cells
… with the nuclear matrix of infected bovine fetal lung cells as shown by Southern blot analysis of matrix DNA isolated by two procedures differing in the order of exposure of detergent-treated nuclei to high salt conditions and DNase I. Protein analysis of the two matrix types showed the …
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The role of ceramides in cigarette smoke-induced alveolar cell death
… pathways that can be manipulated to reduce lung cell apoptosis. CS increased ceramides in the whole lung and in cultured primary structural lung cells. Exposure to CS activated within minutes the acid sphingomyelinase, and within weeks the de novo- ceramide synthesis pathways. …
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A Theoretical Exploration of the Growth and Stability of Alveolospheres
An alveolosphere is a type of stem cell derived lung organoid. They have a distinct “balloon-like” structure which resembles the alveoli in human lungs. In recent years, they have become increasingly popular as model systems for disease research and treatment development, especially with the onset …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic agent found in cigarette smoke. In this study …
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IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
… employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A synthetic IGFBP-3 peptide (<sup>215</sup>-KKGFYKKKQCRPSKGRKR-<sup>232</sup>) but not the mutant (K228AR230A), was able to bind hyaluronan more efficiently than the analogous …
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Investigation of respiratory surfactant A protein in middle ear epithelium
… is variable but which resembles that of the lungs. Lung function depends upon surfactant which is a family of surfactant proteins which have an important role in breathing as well as infection control. Given that both the middle ear and the lungs can suffer collapse as well as infection, it …
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