Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"lung carcinoma"”.
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC …
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C/EBPβ Regulates Tumour Size and Microenvironment Composition in Lewis Lung Carcinoma
… across different cancer types, its role in lung cancer, particularly in the widely used Lewis lung carcinoma (LLC) model, remains poorly defined. The objective of this study was to define the role of C/EBPβ in LLC tumour progression and to characterize how C/EBPβ shapes the tumour …
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Identification of Lung Carcinoma Biomarkers Associated with Tumour Development and Drug Resistance
Lung cancer is the most common cause of death from cancer worldwide, estimated to be responsible for nearly one in five (1.59 million deaths, 19.4% of the total). Lung cancer is acknowledged as a complex and heterogeneous disease, not only at the biochemical level (genes, proteins, metabolites) but …
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Surveillance Imaging Following Curative-Intent Surgery for Non-Small Cell Lung Carcinoma: A Systematic Review
Following curative surgery for non-small cell lung carcinoma (NSCLC), patients remain at risk for recurrence of lung cancer or for development of second primary lung cancer (SPLC). While periodic surveillance may detect early stage recurrence or SPLC, the effectiveness of surveillance has not been …
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
Treatment with the taxanes, docetaxel and paclitaxel, can result in the emergence of multi-drug resistance (MDR) mediated by P-gp (MDR-1, ABCB1), which is an effective cellular efflux pump for both agents. This thesis was undertaken to examine the contribution of drug transport mechanisms to …
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Investigation of the interactions between selected nanoparticles and human lung carcinoma cells at the single cell and single particle level
… between chosen nanoparticles and living human lung carcinoma (A549) cells"--Abstract, page iv.
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
… were injected subcutaneous with 1 x 106 Lewis Lung Carcinoma(LLC) cells. Animals were randomized to one of six groups: no treatment(group 1), celecoxib 25mg/kg daily per oral intake alone(group 2), celecoxib 75mg/kg daily per oral intake alone(group 3), 10 Gy irradiation alone in one …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… and clinical biomarkers for the treatment of lung adenocarcinoma (LUAD), objective response rates are still low at around 20%. Current biomarkers are limited in their ability to stratify patients for predicting response, highlighting the need for novel biomarkers to better guide therapeutic …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, A427, …
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Potential Mechanisms Explaining the Antitumor Effect of Total-Body Irradiation
… TBI produces an antitumor effect in the Lewis lung carcinoma (EEC) model, the major goal of this study was to determine whether changes in tumor growth could be correlated with radiation-induced alterations of immune system parameters. The governing hypothesis was that selective immune …
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Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… which could be beneficial in the treatment of Lung Carcinoma and Neurodegenerative diseases, was investigated. A novel ensemble of proteins was targeted to elevate intracellular cAMP, deemed to be beneficial in these diseases resulting in the discovery of ligands with high binding affinity at …
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Structural and Synthetic Studies of Potential Antitumor Natural Products
… yeast mutants and cytotoxicity to human lung carcinoma cells. In order to improve the activity of cytotoxic furanonaphthoquinones by affixing a hydroxyamino side chain, 2-methyl-2-[2'-(4',9'-dihydronaphtho[2',3'-b]furan-4',9'-dionyl methyl)amino]-1,3-propanediol and its analogs have been …
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… significantly greater anti-tumor effect against lung carcinoma than either modality alone. The underlying mechanisms were postulated to include alterations in the balance of cytokines critical for generating tumor vasculature.</p> <p>pXLG-mEndo, the unique plasmid containing a mouse endostatin …
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The role of c-FLIP in regulating resistance to ionizing radiation
… that F1DAC inhibitors sensitize non-small cell lung carcinoma (NSCLC) cell lines to IR. Furthermore, the radiosensitizing properties of HDAC inhibitors were highly dependent on their ability to suppress FLIP expression.Therefore. FLIP down-regulation induced by HDAC inhibitors is a potential …
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Stellenwert der radikalen Lymphadenektomie in der chirurgischen Behandlung des nichtkleinzelligen Bronchialkarzinoms
… 1990 to 2002 curative surgery for non small cell lung carcinoma in our hospital were reviewed retrospectively. The study was performed to compare the survival benefit from extensive dissection technique with lymph node sampling. We could not demonstrate any benefits from mediastinal …
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Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry
… that treatment with lOyM BrdU in the human lung carcinoma cell line (DLKP) resulted in increased expression of the cytoskeletal proteins Keratin 8 and 18 and the cell adhesion proteins a2 and b1 integrin. This study investigated protein expression changes in differentiating DLKP cells …
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The Effect of Tim-3-Ig on Tumor Growth
… was investigated whether Tim-3-Ig expression in lung carcinoma cells (3LL) affects tumor growth in mice. Second, it was investigated whether administration of purified Tim-3-Ig into mice influences tumor growth. Tumor growth of 3LL cells expressing Tim-3-Ig was suppressed as compared with control …
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Identification of signalling pathways regulating TBX2 gene expression and its target genes
… several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which serves as a barrier to cancer development. However, the precise role of most T-box factors is poorly defined, in part, because their …
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Lung disease diagnosis from gene expression profiles
Lung diseases include some of the most widespread and deadly conditions known to affect people in the US today. One of the main challenges in treating lung disease is the difficulty of diagnosis. Clinical diagnosis remains largely dependent upon symptomatic-based diagnoses; many cases can be either …
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