Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"lung adenocarcinoma cells"”.
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Genetic differences in lung adenocarcinoma cells from patients of African and European ancestry
… elucidate clinically significant disparities in lung adenocarcinoma (LUAD) genetics across distinct ethnicities, particularly focusing on African ancestry (AA) and European ancestry (EA) populations. A meticulous comparison of genetic traits within LUAD cells derived from these ethnic groups is …
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Identification of TMEM2 as a SOX4 Transcriptional Target Involved in Breast Cancer Metastasis
… activated by SOX4 in both breast cancer and lung adenocarcinoma cells and mediates pro-invasive and pro-migratory effects of SOX4. TMEM2, like SOX4, is sufficient to promote breast cancer metastatic colonization and its expression in high-risk primary breast tumors associates with metastatic …
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Fibulin-2 Stabilizes Tumor Extracellular Matrix and Drives Malignant Progression of Lung Adenocarcinoma
… these deficiencies using mouse models of human lung adenocarcinoma. Spontaneous lung tumors were marked by disorganized basement membranes, dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein …
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Identification and functional study of a novel antimicrobial peptide, QUB-2014, from the skin secretion of the frog, Phyllomedusa tomopterna
… showed anticancer cell proliferative activity on lung adenocarcinoma cells at a concentration of 10-4 M. On the other hand, the haemolytic activity of this novel peptide was relatively weak, which was approximately below 10% of haemolytic rate from the concentration of 1 μM to 32 μM. Taken …
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Oncogene-driven post-transcriptional regulation in lung cancer
Lung cancer is often caused by genetic mutations which alter the activity of proteins in the RAS family, with somatic mutation of the KRAS gene occurring in ~30% of lung adenocarcinoma tumors. A gene of the same family, RIT1, is mutated or amplified in 10-15% of lung adenocarcinomas. Although …
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Identification of the RNA Cis-Elements that Interact with SRp30a to Regulate the Alternative Splicing of Caspase 9 Pre-mRNA
… RNAi technology to downregulate SRp30a in A549 lung adenocarcinoma cells induced an approximately 75% decrease in SRp30a expression and induced a dramatic change in the ratio of caspase 9a/caspase 9b. Therefore, these studies have identified SRp30a as a major regulator of the alternative …
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Loss of Gprc5A Enhances Survival In Normal and Malignant Lung Epithelial Cells By Eliciting Persistent Stat3 Activation Induced By Autocrine Lif
… C, group 5, member a (Gprc5a) gene develop lung tumors indicating that Gprc5a is a tumor suppressor. In the present study, we examined he mechanism of Gprc5a-mediated tumor suppression. We found that epithelial cells from <em>Gprc5a</em> knockout mouse lung (<em>Gprc5a</em><sup>-/-</sup> …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
… and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support amino acid homeostasis in cancer cells is critical to identifying novel vulnerabilities in cancer metabolism and is the subject of …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
… and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support amino acid homeostasis in cancer cells is critical to identifying novel vulnerabilities in cancer metabolism and is the subject of …
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Role of Ceramide-1-Phosphate as a Specific and Potent Activator of Group IVA Cytosolic Phospholipase A2 Alpha
… critical for translocation of cPLA2α in A549 lung adenocarcinoma cells in response to inflammatory agonists like A23187 and IL-1β. Lastly, we also demonstrated the mechanistic difference between activation of cPLA2α by the two anionic lipids, C1P and PI(4,5)P2.
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
Lung cancer is the most prevalent cancer type, leading to more than one million deaths per year worldwide. The vast majority of these mortalities were attributed to metastasis, which is the dissemination of tumor cells from the lungs to other organs. The molecular mechanisms for metastasis is …
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DESIGN OF NOVEL ORGANIC MOLECULES AND METAL COMPLEXES WITH BIOLOGICAL PROPERTIES
… as prototypes for the study of ER stress both in lung adenocarcinoma cells (A549) and in the healthy expandable lung epithelial progenitors’ cells (ELEP), recently differentiated by Prof. Vaňhara’s group. The obtained results confirmed that the studied complexes were able to inhibit cancer cell …
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Engineered microtissue platforms for modeling human pathophysiology and drug metabolism
… generator was designed to encapsulate tumor cells with stromal cells and extracellular matrix in 100 pm-diameter poly(ethylene glycol) (PEG) microtissues (6000 microtissues/min). Upon screening a small panel of soluble stimuli, TGF-p and the TGF-pR1/2 inhibitor LY2157299 were found to have …
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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer
… for targeted drug delivery to nonsmall cell lung cancer (NSCLC). Erlotinib (ETB) is a highly selective, potent and reversible inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR) which is overexpressed (50-90%) in NSCLC. ETB is marketed as film coated tablets for oral …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… field dependent targeting to the left ventral lung after thoracotomy; controls were insufflated with the NIMs in the absence of magnetic field dependent targeting. Quantification of deposition of the dye component (drug surrogate) of NIMS in left and right lung tissue showed an increase in …
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Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
Lung cancer is the leading cause of cancer-related deaths in our society due to the inefficiency of early detection strategies and the high rate of treatment failure. Therefore, a better understanding of the mechanisms underlying its origin and the response to current treatment paradigms are …