Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"lumenogenesis"”.
-
Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
The molecular links between epithelial lumenogenesis and tissue-level morphogenesis in the pancreas remain elusive despite a decade of studies. Here, I show that deletion of Rab11A and Rab11B (Rab11) in the developing pancreatic epithelium (Rab11pancDKO) disrupts both of these processes. The loss …
-
Mechanisms and dynamics of size regulation and lumen formation in mouse double embryos
… achieved through lengthening of the cell cycle, lumenogenesis is dependent on programmed cell death in double embryos. In fact, increasing epiblast size results in a multi-layered epithelium in which multiple luminal cavities arise, whose fusion is mediated by apoptosis of inner cells lacking …
-
Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… PKC[epsilon] and PKC[zeta] as regulators of EC lumenogenesis in 3D collagen matrices. We further show that Src family kinases (SFKs) are involved in this PKC [epsilon]-mediated EC lumen formation process. SFKs also interact with Cdc42 during EC lumen formation in a PKC [epsilon] dependent …
-
Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… activation of Rab11a in epithelial cells during lumenogenesis and that their activities are repressed by Tankyrase-mediated PARylation. RNF146 regulates Rab11a activity by controlling Tankyrase protein abundance, marking the first time that RNF146 has been described as antagonistic towards …
-
A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… including altered apicobasal polarity, perturbed lumenogenesis, global endolysosomal dysfunction, and a markedly altered plasma membrane proteome and lipidome. Together, I have forwarded our understanding of SFTPC handling in health, and the pathogenic consequences of its accumulation in disease. …
-
Cell mechanics-based modelling and in toto imaging describe a new mode of lumen formation in chicken neural tube
… tissue subsequently transitions to a distinct lumenogenesis process that forms a dorsal epithelial surface first and a single central lumen that enlarges ventrally from HH12-14. This intermediate behaviour matches our model prediction and confirms a separate de novo cavitation behaviour to the …
-
The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
The neural tube is an epithelial tube that forms the embryonic brain and spinal cord through the process of neurulation. In amniotes, it forms in two different ways: in the anterior region, primary neurulation occurs through the folding of an already polarised epithelial sheet; and posteriorly, …