Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"low-shear stress"”.
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Shear Thickening In Dense Bidisperse Suspensions By Dynamic Simulation
<p>Shear thickening, which corresponds to an increase of viscosity with shear rate, is ubiquitously observed in many concentrated suspensions and, as such, has implications for many industrial materials and geological phenomena. Controlling shear thickening is of significant importance, and many …
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FABRICATION AND CHARACTERIZATION OF CELL-LADEN 3D PRINTED HYBRID SCAFFOLDS FOR ESOPHAGEAL TISSUE REPAIR
… printing on porous scaffold precisely with low shear stress to produce homogeneous cell-laden hybrid scaffold. These results demonstrate the potential of the hybrid 3D scaffold in organized tissue reconstruction for esophagus healing.
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IMPACT OF BIOPHYSICAL CUES ON THE FUNCTIONAL MATURITY OF PLURIPOTENT STEM CELL DERIVED ENDOTHELIAL CELLS INTO ARTERIAL AND VENOUS SUBTYPES
… basement membrane architecture and different shear stress. Thus, this study incorporated a Multi Architectural (MARC) chip to study the effect of substrate topography and a multiplex microfluidic device to study the effect of shear on the functional maturity of PSC-EC into the two EC subtypes. …
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Investigation of a trapezoidal microchannel for hydrodynamic detachment of cells or biomolecules.
… utilizes the characteristic pressure-driven flow of microfluidics to detach cells or biomolecules at the narrow region of interest while enabling flexibility in the rest of the channel with larger height and low shear stress. A fluid dynamics analysis was performed analytically and using …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
… to bouts of intermittent hypoxia (IH) and high shear stress as proxies for PA. Hypoxia was considered 3% and normoxia 10% O2. Low shear stress was defined as 1 dyn/cm2 and high shear stress as 3 dyn/cm2. DHA was added to the cell culture media, and uptake into cells was quantified by gas …
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A passive microfluidic device for continuous buffer exchange
… it is required to resuspend the cells into a low-conductivity fluid buffer. The use of a low conductivity buffer also aids in minimizing the effects of Joule heating, which can cause cell death and ineffective cell trapping. The common method to prepare the sample relies on centrifugation of …
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Direct numerical simulation of microjets for turbulent boundary layer control
… a turbulent boundary layer for the purposes of flow control. Initial studies were used to first ascertain the correctness of the model and give insight into the performance characteristics of the devices. To this end, a flow and geometric parameter study was conducted on a 2-D simulation of the …
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Formulation studies on cysteamine for the treatment of nephropathic cystinosis.
… that a weak gel network was formed at low shear stress, the bioadhesion of the gel was increased with inclusion of a cysteamine derivative (e.g. mean force of 0.067N compared to 0.107N, with compound included) and eight-hour, first-order release from the gel was observed. There was …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For …
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Investigating Transluminal Endothelial Bridging in a Microvessel-on-a-Chip
… transluminal bridges against the force of blood flow remains enigmatic, largely due to the challenges of visualising this seemingly stochastic event in vivo and the lack of in vitro models. To elucidate this bridging process, I employed a vessel-on-a-chip strategy where various transluminal …
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The effects of low-shear modeled microgravity on Streptococcus pneumoniae and adherent-invasive Escherichia coli
The effects of low-shear modeled microgravity (LSMMG) were investigated on Streptococcus pneumoniae global gene expression and on adherent-invasive Escherichia coli (AIEC) physiology and colonization properties. Habitation in space exposes both humans and microbes to microgravity conditions which …
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Chronic Shear Stress Effects on Endothelial Cell Response
… focus of this dissertation is on how chronic shear stress alters the synthesis and secretion of important regulatory molecules by endothelial cells. Our hypothesis was that inclusion of chronic pulsatile shear stress in our model would lead to changes in endothelial cell release of regulatory …
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The role of biofilms in Legionella pneumophila transmission in drinking water distribution system
… biofilm materials or by the drinking water flow shear stress. Biofilm properties (e.g., physical structure and mechanical stiffness) play an important role during this L. pneumophila transmission process. However, the knowledge on how the biofilm properties control L. pneumophila transmission …
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Impact of cross section, web reinforcement and load history on the seismic performance of slender concrete walls
… in seismic regions employ reinforced concrete shear walls as part of the lateral force resisting system and these walls often have non-planar cross-sectional geometries. To date, the majority of experimental tests on slender concrete walls have been conducted on planar walls which have been …
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The Effects of Vegetation on Stream Bank Erosion
… by measuring the erodibility and critical shear stress of rooted bank soils in situ using a submerged jet test device. Additionally, several soil, vegetation, and stream chemistry factors that could potentially impact the fluvial entrainment of soils were measured. A total of 25 field sites …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
… to an hCMEC/D3 monolayer was studied under low shear stress levels to mimic in vivo conditions. Interrogation of the tumour proteins secreted into the conditioned medium was performed using commercial Proteome Profiler kits and ELISAs. The impact of tumour secreted proteins on astrocyte …