Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"low-grade glioma"”.
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… markers that can determine progression of low grade glioma. This was done using various approaches such as IDH1 and IDH2 mutation analysis, MGMT methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially expressed miRNAs …
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Functional analysis of low grade glioma genetic variants using statistics and physics-inspired deep learning methods
… risk of diseases, including cancer. For low grade gliomas (LGGs), at least 25 risk loci have been identified, whose molecular functions, however, remain largely unknown. Understanding how the risk loci function in tumorigenesis poses a major challenge in the field, owing to potential …
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The effect of neurosurgical intervention and neurological damage on the perception of dyspnoea
… damage in the form of Parkinson’s disease, and glioma of the insular cortex alters the perception of breathlessness. Methods: (i) Experimental air hunger was induced in participants with deep brain stimulation of the motor thalamus to assess whether perception of dyspnoea is changed when …
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Characterisation of cytokine secretion in malignant gliomas
… pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte subset analysis was performed using flow cytometry. Serum specimens taken from both high and low grade glioma patients were analysed with samples taken from control patients with no history of cancer. …
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Evaluation of miR-497 & miR-219 as non-invasive biomarkers for meningioma and glioma
… classification aids in predicting meningioma and glioma recurrence and prognosis. However, there is a dearth of circulating biomarkers with clinical value for meningioma diagnosis and classification. Circulating miRNAs have shown potential as cancer biomarkers in various tumours. This study …
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Comprehensive Analysis of the Molecular Underpinnings of Pediatric Glioma
… tumors affecting children. Of these CNS tumors, gliomas are the most prevalent. Currently gliomas are histologically segregated into two umbrella categories: low-grade glioma (grades 1 and 2, pLGG) and high-grade glioma (grade 3 and 4, pHGG). pLGG are the most frequently diagnosed pediatric …
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Novel Oncogenic Drivers in Pediatric Gliomagenesis
<p>Pediatric high-grade gliomas (pHGGs), with a two-year survival rate of less than 20%, are some of the most aggressive human cancers. This dissertation begins with our analysis of 127 pHGGs, including brainstem (BS) and non-brainstem (NBS) tumors, from 118 patients using next-generation …
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Pre-operative Functional Magnetic Resonance Imaging: Application to Tumour Resection by Awake Craniotomy
… of fMRI data is shown to be comparable in low-grade glioma (LGG) patients and healthy controls, but poorer in high-grade glioma (HGG) patients. More reliable activation patterns are demonstrated for motor tasks than for language tasks. The third project explores “Sources of variation …
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An automated classification system to determine malignant grades of brain tumour (glioma) in magnetic resonance images based on meta-trainable multiple classifier schemes
The accurate classification of malignant grades of brain tumours is crucial for therapeutic planning as it impacts on the tumour’s prognosis, where the higher the malignancy levels of the brain tumour are, the higher the mortality rate is. It is also essential to provide patients with appropriate …
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Exploring the brain mechanisms of breathlessness through the study of neurological patients
… for Parkinson’s disease, and (c) patients with low-grade glioma affecting the insular cortex. Results: Group a (n=16): Thalamic DBS produced significant relief of steady-state AH (p=0.002) with a mean±sd reduction of -14.4±15.5% on a visual analogue scale (VAS), exceeding the minimal clinically …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… properties of brain cancer for various-grade glioma cells (healthy astrocytes, grade II, grade III, and grade IV (glioblastoma) cells). A microfluidic constriction channel caused cell deformation as cells, driven by hydrostatic pressure, entered a narrow constriction. Finite element …
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Modeling of Cns Cancer With A Focus On The Immune Component
… microsatellite instability, had relatively low tumor mutational burden, but did express PD-L1 protein, indicating potential use therapeutic use for immune checkpoint inhibition. We identified mutations not previously described, including an <em>E318K</em> missense mutation in the …