Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 185 for “"low-density lipoprotein"”.
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
The Low-Density Lipoprotein Receptor gene family is a group of ancient membrane receptors. Originally implied in cargo transport and development of atherosclerosis, the number of members and the diversity of functions have been greatly expanded. LRP1, LRP1b and LRP4 are gene family members that are …
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Post-translational processing of the low density lipoprotein receptor
The low density lipoprotein (LDL) receptor is a transmembrane glycoprotein that mediates the uptake of plasma LDL and thereby provides cholesterol to cells. During its synthesis in the endoplasmic reticulum, the LDL receptor folds and forms disulfide bonds in multiple cysteine-rich repeats. N- and …
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Low density lipoprotein transport and metabolism in the arterial wall
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1985.
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… I identified this locus as a member of the low-density lipoprotein receptor-related protein (LRP) family, and designated it lrp13b. I have found that ethanol teratogenesis in lrp13b mutants is made more severe by increased developmental temperature. Mutants in lrp13b experienced increased …
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The cellular degradation of the low density lipoprotein receptor and its ligand
The cellular degradation of the low density lipoprotein (LDL) receptor, and its ligand, LDL, were investigated in order to clarify certain mechanistic aspects of these important processes. Long-term lymphoblastoid cell lines and cultured human skin fibroblasts were used to examine the fate of …
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The expression and metabolism of low density lipoprotein receptors in familial hypercholesterolaemia
… Newly-synthesized precursors were processed slowly (t½ 1.5 hours versus normal t½ of approximately 15 minutes) to mature receptors which reached the cell-surface, but were rapidly degraded thereafter with a half-life of approximately 1.7 hours (normal value 12.6 hours) thus representing a new …
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The characterisation of the ectodomain shedding of the low density lipoprotein receptor
Includes abstract. Includes bibliographical references (leaves 142-155).
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… biosynthetic pathway. Megalin, a member of the low density lipoprotein family of receptors, is sorted apically in polarized epithelial cells via a sorting signal present in its cytosolic domain. I show that the cytosolic domain of megalin associates with sorting nexin 17, a protein that …
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Low Density Lipoprotein Cholesterol Decreases in Fifth-grade Students Following the Teen Taught KidQuest Program
… 10! Activities) groups. Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, and BMI were measured at baseline, completion of the program (six months), and at 12 months. <br /><strong>Results:</strong> Ninety-one subjects, mean age (±SD) of 10.91 ± …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… inflammation 1 B. Gangliosides and oxidized low density lipoprotein (oxLDL) 2 1. Gangliosides 2 2. OxLDL 3 C. Inflammatory signaling pathways 7 1. JAK-STAT pathway 7 2. Lipopolysaccharide (LPS) –induced signaling pathways 8 3. Liver X receptor (LXR) pathway as anti-inflammatory signaling …
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Proatherosklerotische Wechselwirkung von oxidativem Stress, Low-Density-Lipoprotein, Angiotensin II und Endothelin-1 in humanen Endothelzellen
… Entstehung einer Atherosklerose spielt eine Hyperlipoproteinämie eine entscheidende Rolle. Ein weiterer Faktor für die Entstehung kardiovaskulärer Erkrankungen ist ein hoher Blutdruck. In dieser Arbeit wurde eine mögliche Interaktion zwischen Lipoproteinen und den blutdruckregulierenden …
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Development and application of a novel method to determine large very low density lipoprotein (VLDL1) kinetics
High concentrations of large very low density lipoproteins (VLDL1) give rise to atherogenic dyslipidaemia, which is usually associated with insulin resistant conditions (e.g. obesity) and increases the risk for cardiovascular disease (CVD). Isotopic tracer methods for determining VLDL1 kinetics are …
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Studies of CD36 interacting with fatty acids, oxidized low-density lipoprotein, and the cellular plasma membrane
… and endothelial cells. CD36 binds oxidized low density lipoprotein (oxLDL), which promotes atherosclerosis, and fatty acids (FA), which promotes their cellular uptake. To gain insights into the molecular mechanisms of uptake, HEK293 cells expressing CD36 were studied by cell biological and …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… in rats. This nanoparticle is comprised of the low-density lipoprotein which acts as a carrier for the omega-3 fatty acid docosahexaenoic acid (DHA). The LDL-DHA nanoparticle has demonstrated cancer selective cytotoxicity with little ill effects on healthy cells. Our research began by selecting …
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The effects of Bios Life and exercise on total cholesterol, serum low-density lipoprotein, and high-density lipoproteins
… dietary fiber supplement, on serum lipoproteins and determine whether exercise accentuates this effect. Fifty male and female subjects (ages 30--60) participated in the study. Twenty-five subjects were exercising regularly in a supervised exercise program and the other twenty-five …
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