Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"low affinity site"”.
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Pharmacological, functional, and biochemical characterization of a high-affinity angiotensin receptor on differentiated NG108-15 cells
… analysis revealed the existence of high and low affinity sites in differentiated cells, but only a low affinity site in undifferentiated cells. Similarly, self-displacement studies revealed competition to a single low affinity site in undifferentiated cells, and to high and low affinity sites …
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Hydrolysis and Toxicity of Aspartyl Peptides and the Influence of Metal Ions on Aspartyl Peptide Hydrolases in Salmonella Enterica Serovar Typhimurium
… on Mn2+. Purification of this activity followed by N-terminal sequencing of the protein suggested that the Mn2+-dependent peptidase is DapE, N-succinyl-L,L-diaminopimelate desuccinylase. Disruption of the dapE gene and transfer of the mutation into a MPD strain yielded a strain with extract …
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The Structural Requirements of Gastrin and Glycine-Extended Gastrin for Binding to Receptors from Normal and Cancerous Human Tissues
… in a marked decrease in binding. The binding affinity is strongly correlated with the biological activity of each analog, demonstrating little role for the residue at position 17 in receptor activation. Based on these results, the use of des-Phe analogs of gastrin is not an appropriate …
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Μελέτη των θέσεων δέσμευσης του L-γλουταμικού οξέος σε φυσιολογική και ατροφική ανθρώπινη παρεγκεφαλίδα: Συμβολή στη μελέτη της ελαιογεφυρο-παρεγκεφαλιδικής ατροφίας
… and/ CI⁻independent L-glutamate binding sites were studied in membrane preparations and sections of human cerebellum. Furthermore L-glutamate binding have been solubilized from the same membrane preparations using different detergents, as CHAPS, Zwittergent 3-12 and Digitonin. At last, a …
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The interactions of cytochrome bo3 from Escherichia coli with its substrates - ubiquinone and oxygen
… a soluble quinol substrate, indicate one high affinity quinone binding site, which acts as a non-exchanging co-factor, and a second, low-affinity site which is the substrate site. The residues interacting with the quinone at the high affinity QH site are well defined through numerous …