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Showing 1 to 20 of 23 for “"lovastatin"”.
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Einfluss der HMG-CoA-Reduktase-Inhibitoren Atorvastatin und Lovastatin auf die Regulation der Hepatischen Lipase
… vitro posttranslationell durch Atorvastatin bzw. Lovastatin reguliert wird. Dies geschieht durch die statininduzierte Aktivierung des Proteasoms, für das das HL-Protein als Substrat zu dienen scheint. Die Kompetition mit einem Hemmer des Proteasoms, MG-132, hebt den vorzeitigen und/oder …
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An investigation involving a comparison between the hydrolytic degradation of lovastatin and simvastatin using HPLC
Lovastatin (LV) and Simvastatin (SV) are known by their common general name of Statins. They are hypolipedemic drugs used for the treatment of hypercholesterolemia. Both statins are administrated as prodrugs that require metabolic activation to form the active acid forms, namely lovastatin hydroxy …
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… coenyzme A (HMG-CoA) reductase inhibitor, lovastatin, promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, lovastatin also contradictorily relieves or exacerbates memory loss in Alzheimer's patients (Wagstaff et al., …
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Roles of cholesterol in the proliferation and differentiation of bovine myoblasts
… myoblasts were cultured with or without lovastatin, a selective inhibitor of cholesterol synthesis. Culturing with 5 μM lovastatin did not affect medium concentration of cholesterol, but reduced cytosolic and membrane cholesterol contents, compared to culturing with vehicle control. …
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Investigation of the effects of Elicitation and Quorum sensing on Monascus purpureus C322
… red yeast rice, is known for its production of lovastatin—a compound effective in reducing cholesterol—and various pigments (red, yellow, and orange). This study aims to enhance the production of these metabolites using biotic elicitors, such as oligomannuronate (OM), oligoguluronate (OG), and …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… GGTI-2Z and FTI-1, were used in combination with lovastatin in STS-26T malignant peripheral nerve sheath tumor (MPNST) cells. We found that GGTI-2Z/lovastatin inhibit proliferation, cause cell cycle arrest in the G1 phase and induce autophagy in STS-26T MPNST cells. FTI-1/lovastatin not only …
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Modelling fragile X syndrome in rats: new directions in translational research
… whether early therapeutic intervention with lovastatin can restore the cognitive deficits I observed. Subjects were fed either a diet containing lovastatin (“lovachow”) or an identically looking control diet, between P29 and P64, and tested in the four spontaneous exploration tasks, …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… of lipid microdomains by use of </p> <p>lovastatin diminished the aggressiveness of IBC cells. Cathepsin B </p> <p>activity and association with lipid microdomains was reduced in </p> <p>lovastatin treated IBC cells. Lovastatin treatment also reduced type </p> <p>IV collagen degradation …
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Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas
… studies we demonstrated the impact of hCG and lovastatin in combination with ionizing radiation to radiosensitize and enhance tumor cell lethality. This enhancement was attributed to the hCG-induced activation of ERBB1 via a GPCR, MEK112 and metalloprotease dependent paracrine mechanism which …
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Investigating Physical and Chemical Interaction of Aspergillus terreus Spores for Changes in Morphology and Physiology
… that seen of cultures of 1x107 spores/mL (high), lovastatin production also increased by 1208%. Similarly, the morphology of low spore cultures supplemented with FDSS were that of high spore cultures and lovastatin production increased by 67%. Sonication had no effect on cultures, however, …
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Formation of optimised particles for formulation and processing
… process. Spherical agglomerates of lovastatin were prepared by suspension of crystals in water and agglomeration through the action of another solvent called bridging liquid. All the solvents except alkenes led to the formation of spherical agglomerates as long as a sufficient amount …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… neurite outgrowth studies on cells treated with lovastatin and found statin administration increased neurite branching. Global inhibitors do not give us a good indication of what is causing the observed effect as they do not implicate how inhibiting the prenylation of a specific protein leads to …
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… that exposure of leukemia cell lines to lovastatin (20 uM, 18 hours) and UCN-01 (100 nM, 18 hours) resulted in mitochondria dysfunction, procaspase 3 and 9 cleavage, and PAW degradation along with marked cytochrome C release and apoptosis. Although similar molecular mechanisms have not …
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Structure Determination of Natural Product Biosynthesis Enzymes
… are best exemplified by paclitaxel (taxol), lovastatin and penicillin for the treatment of cancer, high-cholesterol-lowering and bacterial infections respectively (1–3). Total synthesis remains the primary strategy for drug and derivative production, however characterization of NP …
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Vergleichende Untersuchung der Wirkung verschiedener HMG-CoA Reduktase Inhibitoren auf die Apoptose normaler und neointimaler Gefäßmuskelzellen
… beobachtet man nur bei den lipophilen Statinen Lovastatin, Simvastatin und Fluvastatin. Das hydrophile Pravastatin zeigt keinen Effekt. Die Apoptoseinduktion in glatten Gefäßmuskelzellen aus der Media war gering bei serumfreien Bedingungen. B). Die Neointima Zellen sind im Vergleich zu den Media …
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Impact of delta-tocotrienol on human melanoma cell proliferation
… on A2058 cell proliferation was potentiated by lovastatin (IC50 = 3.1± 0.5 μmol/L), a competitive inhibitor of HMG CoA reductase. d-δ-tocotrienol may have potential application in melanoma chemoprevention and/or therapy.
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Spatial and temporal analysis of pharmaceutical concentrations and chitobiase activity in the Upper Tennessee River
… fluoxetine, norfluoxetine, diltiazem, lovastatin, and atorvastatin). The simultaneous method pre-concentrated analytes by a factor of 1000 with percent recoveries ranging from 44% to 104% and RSDs below 16%. Percent recoveries were moderately variable due to the broad range of both the …
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Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
… When Insig-DKO mice were treated with lovastatin, an HMG-CoA reductase inhibitor, sterol intermediate levels were significantly reduced and the craniofacial defects were ameliorated. Next, we generated mice lacking Insigs in the epidermis (Epi-Insig-DKO). All Epi-Insig-DKO mice failed …
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The Investigation of Primary and Secondary Modifiers in the Extraction and Separation of Neutral and Ionic Pharmaceutical Compounds with Pure and Modified Carbon Dioxide
… modifiers in the subcritical fluid extraction of lovastatin from in-house prepared tablet powder mixtures and MEVACOR® tablets was investigated. The effect of in-line methanol-modifier percentage, additive type (acidic, basic, neutral) to the in-line methanol, and additive concentration on the …
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Die Bedeutung von Rho-Proteinen für Migration, Zellkontaktbildung und Aktinfilamentdifferenzierung in Endothelzellen
… Rho-Proteinen durch den HMG-CoA-Reduktase-Hemmer Lovastatin unterdrückt. In einer zweiten Versuchsserie wurden alle Rho-Proteine unselektiv durch Toxin-B, einem Toxin aus Clostridium difficile, und anschließend selektiv RhoA durch C3-Toxin aus Clostridium botulinum inaktiviert. Es wurden die …
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