Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"longitudinal sampling"”.
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Developing computational methods to enhance understanding in glioma progression
Longitudinal sampling has provided a wealth of information and opportunities towards studying cancer evolution and heterogeneity. This has helped to determine the origin of some cancers, identify evolutionary patterns and decide how to best treat and study some cancer types. This thesis first …
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Investigating nitrate attenuation in an urban stream using stable isotope geochemistry and continuous monitoring
… further indications of biological processing. Longitudinal sampling revealed decreases in nitrate concentration of 2 and 6.5 mg-l-1 during high and low flow, respectively. During high flow, delta-15N varied from 9.5 to 10.5 per mille downstream of the WTP, while delta-15N varied from 10.14 to …
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… on EVs disseminated from CRC cancer cells to longitudinally monitor mCRC patients and identify immune modulatory signaling molecules that potentially play a role in the progression and metastasis of CRC. Using novel bioinformatics deconvolution pipelines applied to RNA sequencing data of …
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LARGE-SCALE METAGENOMIC ANALYSIS TO IDENTIFY HUMAN GUT MICROBIOME BIOMARKERS OF CARDIOMETABOLIC HEALTH
… disorders linked to altered gut ecology. In a longitudinal dietary intervention, we further observed that improvements in diet quality were accompanied by increased Blastocystis prevalence and abundance, suggesting a potentially beneficial role for Blastocystis in shaping host responses to …
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Impact of Intratumor Heterogeneity and The Tumor Microenvironment In Shaping Tumor Evolution and Response to Therapy
… across three separate cohorts.</p> <p>Through a longitudinal sampling strategy paired to a clinical trial, we characterized the impact of heterogeneity on therapy outcomes after combination ICB agents in multiple sarcoma histologies. Amongst the genomic, transcriptomic and immune-based molecular …
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Applications of Wastewater-Based Surveillance Within Rural and Unsewered Communities
… Highly recommended WBS techniques, such as longitudinal sampling campaigns or metagenomic sequencing, were particularly rare for rural applications, suggesting a potential gap in the generalizability of data derived from those techniques. Notably, conventional septic systems, which treat the …
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Telomere Dynamics of Grey Seals (Halichoerus grypus) on Sable Island, Nova Scotia: a Long-Lived Marine Mammal Population Island
… but rarely in long-lived mammals due to sampling difficulty. This study used an established qPCR assay to measure relative telomere length (rTL) in the grey seals (Halichoerus grypus) of Sable Island, Nova Scotia, a population of long-lived marine mammals approaching carrying capacity. …
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Modelling the age-dependent dynamics of clonal haematopoiesis
… long-term dynamics of CH without the need for longitudinal sampling. Somatic mutations were identified from blood-derived whole exome sequences of 420,000 cancer-free individuals aged 40-70 years. A mathematical model of clonal dynamics based on evolutionary theory was refined and adapted to …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… importance. By taking advantage of the longitudinal sampling during the COVID-19 vaccination campaign, we examined the humoral and cellular immune response of PWHIV, with a focus on the T memory phenotype and vaccine-induced TSCM. To this purpose, we enrolled 22 PWHIV and a control group …