Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"longitudinal monitoring"”.
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Inter-limb asymmetry: longitudinal monitoring and associations with speed and change of direction speed in elite academy soccer players
… of asymmetry is useful as part of the ongoing monitoring process. The aim of study 1 was to use the unilateral isometric squat, unilateral countermovement (CMJ) and unilateral drop jumps (DJ), in a test-retest design, to determine test reliability, the magnitude of asymmetry for both the mean …
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Migration as an adaptive response to ethnic nationalism in Russia
… using panel survey data from the Russia Longitudinal Monitoring Survey, census data, and regional-level political data from Russia. I hypothesize that nationalist political parties send signals of anti-minority sentiment, which ethnic minorities interpret as threatening to their prospects …
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Bone turnover markers and prediction of bone loss in elderly women
… Finally, the effect of precision error on the longitudinal monitoring of change in aBMD was assessed in elderly women (n = 690) and in elderly men (n = 211). There was a strong correlation between all bone turnover markers and the results of scintigraphy (total skeletal uptake of 99mTc-labelled …
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EVALUATION OF THE RISK OF SECONDARY LEUKEMIAS IN CANCER SURVIVORS
… and subclonal CH-related mutations, enabling longitudinal monitoring of CH dynamics in two clinical settings: 73 lymphomas patients and 58 PARP-inhibitor (PARPi)-eligible ovarian cancer (EOC) patients after platinum-based chemotherapy. We used high-sensitivity error-corrected sequencing (limit …
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Insulin Recepto Loss Impairs Mammary Tumourigenesis in Mice
… human obesity. Phenotypic characterization and longitudinal monitoring of mouse tumours, and ex vivo analysis of mammary cells from the generated mouse models revealed that tumor initiation, rather than progression and metastasis, were impacted by INSR deletion. The similarity of phenotypes …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
… high recurrence rates. Current diagnostic and monitoring approaches, primarily relying on MRI and tissue biopsies, have limitations. MRI sensitivity is limited, and tissue sampling is invasive and may not accurately reflect tumor heterogeneity. Thus, the need for a non- invasive strategy to …
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Empowering vision machine perception for robust telehealth applications
… a crisis of bottlenecks in symptom triage and longitudinal monitoring. Digital telehealth toolbox and AI-assisted diagnosis systems offer promising solutions as force multipliers to alleviate these challenges. Among them, smartphone vision-based telehealth exams have gained significant interest …
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Data fusion of complementary information from parietal and occipital event related potentials for early diagnosis of Alzheimer's disease
… despite their access to the outcomes of longitudinal monitoring of the patients.</p>
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… of repeated tumor biopsies for disease monitoring in mCRC patients is often limited. Liquid biopsy utilizing extracellular vesicles (EVs) is an alternative approach for obtaining insights into molecular landscapes of mCRC. Cancer-derived EVs play a critical role in cancer cell-to-cell …
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Detection of trace levels of circulating tumour DNA in early stage non-small cell lung cancer
… having to sacrifice the animal, allowing for longitudinal monitoring in this setting. It may also present an opportunity to frequently sample blood from patients and could reduce the logistical burden on sample collection and processing. In the future, after optimising the protocol, this could …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… test and has the advantage of allowing real-time monitoring of treatment response and comprehensive serial/repetitive phenotypic and genotypic profiling of the primary, metastatic and recurrent tumours. Circulating tumour cells (CTC) and circulating tumour DNA (ctDNA) represent a new generation of …
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PREVALENCE, LONGITUDINAL DYNAMICS, AND FACTORS ASSOCIATED WITH THE FAECAL SHEDDING OF EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING BACTERIA IN ITALIAN NEONATAL DAIRY CALVES
… and ESBL-encoding genes, and investigate longitudinal faecal shedding dynamics during the first months of life. To address these aims, a series of observational studies were conducted. Faecal samples from neonatal or pre-weaned Holstein–Friesian calves, together with selected environmental …
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Optical-Resolution Photoacoustic Microscopy
… In this section, I demonstrate longitudinal OR-PAM monitoring of the morphological: i.e., vessel diameter, length, tortuosity and volume) and functional: i.e., sO2) changes of angiogenic microenvironment at the capillary level, in both a non-disease TetON-HIF-1 transgenic mouse …
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Host and Bacterial Determinants of Staphylococcus aureus Nasal Colonization in Humans
… imperatives. Here, we report on an extensive longitudinal monitoring of SA nasal carriage in 109 healthy individuals over a period of up to three years to assess nasal carriage dynamics. Phylogenetic analyses of SA housekeeping genes and hypervariable virulence genes revealed that not only …
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An alternative diagnostic method using microneedles for sampling the immune system in situ
Current protocols for immune system monitoring involve the collection of cells from blood or cerebrospinal fluid. However, since major populations of immune cells reside within tissues, these invasively-obtained body fluid samples are, at best, indirect indicators of the status of the immune …
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Advancing Technologies for Precision Medicine: From Liquid Biopsy to Single-Molecule DNA Sequencing
… of identifying tumor-associated mutations and monitoring how they evolve during therapy using minimally invasive samples. This dissertation integrates blood-based liquid biopsy assays with an emerging single-molecule nanopore sequencing platform to address limitations associated with …
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Performance of several diagnostic systems on detection of occlusal primary caries in permanent teeth
… essential for early preventive intervention. Longitudinal assessment of caries lesions, especially under the opaque preventive sealant, would be of utmost importance to the dental community. OBJECTIVES: The aim of this two-part in-vitro study is to evaluate the performance of multiple …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… mouse models, this work enables non-invasive, longitudinal monitoring of key biological pathways involved in pato-physiological mechanisms including inflammation, oxidative stress, cell-cycle regulation, and immunoregulatory signalling. Firstly, in vitro reporter-based screening platform was …
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Population-based genotype-phenotype correlation to stratify incident cases of motor neurone disease in Scotland from 2015-2017
… a national electronic platform for prospective, longitudinal monitoring of MND in Scotland. All people with MND (pwMND) diagnosed in Scotland in 2015-17 were included in an epidemiological study of incidence and prevalence of the disease. Patients who consented to sharing their medical records …
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