Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 59 for “"long-term treatment"”.
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… rivastigmine, galantamine) were introduced as treatments for AD. Multiple short-term randomised clinical trials of ChEI treatment show beneficial effects on cognition, global functioning and activities of daily living in AD. Whether the effects of long-term ChEI treatment in a routine clinical …
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An evaluation of the long-term treatment outcomes of a multidisciplinary chronic pain centre program
… (CPC) in Saskatoon offers a multidisciplinary treatment program whose goals are to facilitate improved coping skills, function and well-being, and to promote self-reliant lifestyles. They have documented a statistically significant improvement on several measures of physical and social …
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Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… In this study, investigation was undertaken to determine if lithium ion would regulate expression of BDNF for its anti-apoptosis action. RT-PCR and fluorescence in situ hybridization experiments were performed to determine the lithium-sensitive expression profile in brain and spinal cord. In the …
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Treatment outcomes in perinatally-infected HIV positive adolescents and young adults after 10+ years on antiretroviral therapy
… and success of paediatric antiretroviral treatment (ART) programmes in improving life-expectancy in perinatally HIV-infected (PHIV) children, the burden of paediatric HIV in SA has changed to older children. An increasing population of PHIV children on ART is reaching adolescence, yet …
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Assessing the effectiveness of integrated non-communicable disease and antiretroviral adherence clubs in Cape Town, South Africa
… NCDs. However, there is paucity of literature on long term treatment outcomes for multimorbid patients attending integrated care. We describe long term treatment outcomes among multimorbid patients who attended integrated ART and NCD clubs (IC), a novel model of care piloted in 2014 by the Western …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
… in the conditional inference framework to determine predictors including drug exposure of time-to-stable culture conversion and poor long-term treatment outcomes. The model describing the pharmacokinetics of rifampicin predicted that increasing the dose results in a more than proportional …
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The Effect of Probiotics, Prebiotics, and Synbiotics on Indicators of Lactose Intolerance: A Systematic Review
… food products incentivizes the investigation of long-term treatment options for lactose intolerance. Modifying the gut microbiome to increase the quantity of lactose-hydrolyzing bacteria in the intestines is a promising avenue of treatment that merits investigation. Such modification is typically …
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Fabrication of Vascularized Renal Constructs
… millions of people, but there are few suitable long-term treatment options available to patients. Allogenic kidney transplantation is considered curative, but there are far too few donated kidneys to meet the demand. One possible solution is to engineer renal tissue in the lab that can be used …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
… including renal failure. While dialysis is a treatment option, the survival rate of a dialysis patients is poor. Currently, kidney transplantation is the only long-term treatment possible, but sufficient numbers of transplantable kidneys are not available. Various stem cell therapies and …
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The Matson and Mayville (M&M) seizure scale: an assessment of psychological and environmental variables contributing to seizure activity in persons with mental retardation
… affect clients over what is typically a long-term treatment regimen. Over the last 20 years, literature has emerged emphasizing the importance of environmental variables in the initiation and maintenance of seizure activity. The assessment of such factors and subsequent development of …
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Improving patient outcomes in systemic vasculitis
… death. Making an early diagnosis is difficult. Treatment is usually toxic, and morbidity and mortality from vasculitis is high. Improving the long-term outcomes for patients with these conditions needs a multifaceted approach that encompasses early diagnosis, a better knowledge of the underlying …
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A fully implantable intracochlear drug delivery device : development and characterization
… microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of sensorineural hearing loss. This versatile device is envisioned to deliver multiple therapies and control the sequence and rate of drug dosing. Such a system could have an immediate …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… If administration of an NSAID is required for long term treatment of osteoarthritis, frequent monitoring of blood pressure and renal parameters, as well as hepatic enzymes are recommended.
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Outcomes of penetrating keratoplasty at a tertiary institution in South Africa.
Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and …
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The chronic response to centrosome loss-induced cell cycle exit
… to show some senescence-like features with long-term treatment. However, the nature of cell cycle arrest and its relationship with senescence are still not well understood. The aim of this project is to investigate the temporal dynamics of p53 in centrinone-treated cells and to determine …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… the invasive anti-VEGF therapy is currently a treatment of choice which does not provide long-term comfort to AMD patients. Other treatment options such as surgery and thermal laser photocoagulation did not appear to be safe for long-term treatment. Hence it is crucial to develop an effective, …
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An evaluation and comparison of current FDA-approved treatments for obesity
… sleep apnea. Prior to the new millennium, treatment of obesity included lifestyle modifications or bariatric surgery. However, this alienated a large subset of the population who were unable to lose weight with behavioral changes alone but not obese enough to qualify for bariatric surgery. …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
Existing treatments for mantle cell lymphoma (MCL) are non-curative, demonstrating a need for a refined treatment approach. Recent clinical trials have shown promising results with the use of mammalian target of rapamycin inhibitors. I hypothesize that the anti-tumor effect of mTOR inhibitors in …
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A comparison of two forms of treatment for children with attention deficit hyperactivity disorder: effects on executive functioning and behaviour
… including psychostimulants and multimodal treatments (medication and behavioural therapy). Whilst the short term efficacy of these treatments is supported, there is a relative absence of convincing empirical evidence to support long term treatment in improving behaviour and cognition. …
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Evidence based investigation and treatment of disorders of female reproduction
… centred on the evidence based investigation and treatment of reproductive disorders in women and includes subthemes of evidenced based medicine, infertility and the long term management of Polycystic Ovary Syndrome (PCOS). The candidate’s published work encompasses a broad spectrum of the …
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