Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"long-term potentiation"”.
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Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation
… mice are unable to support the induction of long-term potentiation, a type of synaptic strengthening thought to underlie learning and memory. The ability of 24-hydroxylase knockout slices to exhibit long-term potentiation can be restored by treatment with geranylgeraniol, an isoprenoid …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… glutamate receptors (NMDARs) is required for the long term potentiation (LTP) and long term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, and plays an important role in learning and memory. In addition, it is accepted that the over-activation of NMDARs leads to …
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스트레스에 의한 Long-term potentiation (LTP)의 저하를 감소시키는 리튬의 효과
PURPOSE: The hippocampus is crucially involved in memory formation which has been known to be highly sensitive to stress. Previous studies have been show that exposure to uncontrollable stress is deleterious to hippocampus-dependent memory formation. Recent studies have demonstrated neuroprotective …
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Morphological Correlates Of Synaptic Plasticity After Long Term Potentiation In The Rat Hippocampus
… rat hippocampal formation after the induction of long-term potentiation (LTP) of the perforant path, although few studies have investigated such parameters in the maintenance phase of L-LTP. Moreover, the results of investigations of synaptic and neuronal morphometry changes after LTP have varied …
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Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
… NMDA receptors. In particular, leptin induces a long-term (P5-8) or transient (P11-18) depression of synaptic transmission that depends on GluN2B subunit-containing NMDA receptors in juvenile hippocampus, whereas leptin evokes long-term potentiation that depends on GluN2A subunit-containing NMDA …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local stimulation approach in combination with intracellular recordings and …
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Ultramorphological Study of Synaptic Activity and Efficacy Change in the Perifused Rat Hippocampal Slice
… which did not produce efficacy change. Long term potentiation in hippocampal CA1 was used as a model of efficacy change. After potentiating stimulation (100Hz for 1 s or 200 Hz for 0.5 s), there were increases in numbers of shaft and nubbin synapses, suggesting an increase in the number …
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CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE
… water maze, electrophysiological recordings of long-term potentiation (LTP) and long-term depression (LTD) in anesthetized rats, and immunoblot analyses of learning- and memory-related signaling and AD-related molecules. Chronic psychosocial stress was induced using a rat intruder model. The …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… reflected in an in vitro model of plasticity, long-term potentiation, in amygdala pathways. Chronic cocaine withdrawal did not affect mGluR5-mediated LTP in the basolateral to central amygdala pathway. However, mGluR1-mediated LTP was reduced after cocaine administration and withdrawal and was …
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EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… slices show the involvement of this pathway in long-term potentiation (LTP) in neurons after PI3K and BDNF were able to rescue LTP following microglial ablation. Understanding the mechanisms by which microglial PI3K influences synapses provides insights into the ways it can modulate synaptic …
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The roles of αCaMKII and Ras-GRF2 in the establishment of drug addiction
… a cellular level, many drugs of abuse induce a long term potentiation-like state in the dopamine (DA) neurons of the ventral tegmental area (VTA), a process which enhances synaptic transmission and potentiates signals for longer within the cell. This is a major cellular mechanism underlying …
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Direct current stimulation modulates LTP and LTD: activity-dependence and dendritic effects
… To model endogenous plasticity I induced long-term potentiation (LTP) and depression (LTD) at Schaffer collateral synapses in CA1 of rat hippocampal slices. When induction was paired with concurrent DCS, the resulting plasticity was biased towards potentiation, such that LTP was enhanced …
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Long-term activity-induced changes in the brain : a study of translational regulation and structural plasticity
Long-lasting changes must take place in the brain to store the skills and memories that have been learned by the organism throughout its history. Long-term memory (LTM), and its cellular correlate, the late-phase of long-term potentiation (L-LTP), require protein synthesis. It has generally been …
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The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
… is essential for both memory formation and the long-lasting changes in synaptic strength that accompany learning. However, it's still unclear when protein synthesis needs to occur relative to the experience to form durable memories, and the identities and roles of crucial proteins in these …
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Immunological investigations into synaptic plasticity
… from passive avoidance training in the chick and long-term potentiation in the rat. These studies fell into three categories: 1) the disruption of memory for a one-trial passive avoidance task by intracranial injection of an anti-postsynaptic density antiserum 2) mapping time- and locus-specific …
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Effect of chemically induced mGluR-dependent long-term depression on dendritic spine volume
… synapses that express any form of LTP and LTD (long-term potentiation and depression, respectively) are tagged in a protein synthesis-independent manner, the induction of LLTP/ L-LTD leads to protein synthesis, and all tagged synapses can use the resulting plasticity-related products to express …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
… correlates of such plasticity measurements, ie long-term potentiation (LTP) and long-term depression (LTD). Complete removal of NMDA receptors abolishes plasticity, while selective removal of NMDA receptors from distinct circuits in the visual system can reveal a more specific requirement and …
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Low-Frequency-Induced Synaptic Potentiation: a Paradigm Shift in the Field of Memory-Related Plasticity Mechanisms?
… down regulation of synaptic strength (i.e., long-term potentiation, LTP; long-term depression, LTD) mediates learning and memory processes. Typically, high-frequency stimulation (HFS) of afferent fibers results in LTP, while low-frequency stimulation (LFS) elicits LTD. In stark contrast to …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… microscopy, and electrophysiologic tools, we determined that late Pten loss does not affect hippocampal development, neuronal or synaptic structure or basic synaptic transmission. However, it does cause deficits in both major forms of synaptic plasticity, long-term potentiation and long-term …
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