Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"long term efficacy"”.
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EVALUATION OF LONG-TERM EFFICACY OF FORCED ERUPTED TEETH FOR RESTORATIVE PURPOSES – A CLINICAL RETROSPECTIVE STUDY
… in the literature is lacking in regard to the long-term (> 1 year) prognosis of forced erupted teeth. Aim: To evaluate the long-term (>1 year) stability of teeth that have been orthodontically treated with forced eruption for restorative purposes. Materials and Methods: This study is an …
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Assessing Reliability of Expert Ratings Among Judges Responding to a Survey Instrument Developed to Study the Long Term Efficacy of the ABET Engineering Criteria, EC2000
<p>In today’s assessment processes, especially those evaluations that rely on humans to make subjective judgements, it is necessary to analyze the quality of their ratings. The psychometric issues associated with assessment provide the lens through which researchers interpret results and important …
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The Long-Term Effects of Low Level Laser Therapy (LLLT) Combined with Complex Decongestive Therapy (CDT) in the Treatment of Breast Cancer Lymphedema: A Double-Blind, Randomized, Placebo-Controlled Study
… for lymphedema treatment, fails to demonstrate long-term efficacy. The purpose of this study was to determine the long-term efficacy of low level laser therapy (LLLT) in reducing post-mastectomy lymphedema when used with CDT. The experimental group received LLLT and CDT (n = 7) while control …
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
… a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the context of these regenerative medicine challenges. An affinity-based system was developed whereby …
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Studies on the Application of Multiwalled Carbon Nanotubes for the Thermal Treatment of Cancer
… compatibility with normal tissues and their efficacy as therapeutic agents. In this thesis we investigated these aspects of the biomedical translation of carbon nanotubes (CNTs) through three aims: 1) To determine the role of chemical modifications in mediating blood toxicities during …
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CD133 Antibody Conjugation to Decellularized Human Heart Valves For Circulating Endothelial Progenitor Cell Capture
The long term efficacy of heart valve bioprostheses is limited by progressive degeneration characterized by immune mediated inflammation and calcification. To avoid this degeneration, decellularized heart valves with functionalized surfaces capable of rapid in vivo endothelialization have been …
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Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
… with chronic hepatitis B. We assessed the long?term efficacy (median follow-up of 20.18 months) of ADV add-on LAM therapy in 89 LAM-resistant patients. Methods: 89 patients (29.2% cirrhotics, 76.4% hepatitis B e antigen positive) with LAM resistant patients who were not experienced ADV …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… unsuccessful clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically whether the lack of late efficacy of local delivery of angiogenic factors could be explained by a comprehensive understanding of local pharmacokinetics (PK) …
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Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
… bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has led to the development of DESs (Drug eluting stents). However long term effectiveness of …
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Exploration of Patient Variables and Characteristics Best Suited for Medical Marijuana Treatment for Anxiety and Depressive Disorders
… stress disorder and anxiety symptoms, although long-term efficacy is still unclear. Results have varied with depressive disorders regarding the successful reduction of depressive symptoms. Conversely, studies have shown that medical marijuana and recreational marijuana use may exacerbate …
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Efficacy and safety of iopanoic acid for treatment of experimentally-induced hyperthyroidism in cats
Objective: To determine the efficacy and safety of iopanoic acid for the treatment of experimentally-induced hyperthyroidism in cats. Animals: 15 healthy adult domestic short hair cats Procedures: Hyperthyroidism was induced by daily subcutaneous administration of levothyroxine for 42 days. On day …
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Targeting the human papillomavirus for prevention of cervical cancer
… lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). Comparing 108 cervical cancers cases and 517 matched controls nested within a …
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Decision Support Software for Palmer Amaranth Weed Control
… consultants with tools to evaluate the long-run biological and economic implications of different Palmer amaranth weed control practices, producers are expected to realize the benefits of adopting IPM strategies. As such, the Palmer Amaranth Management (PAM) software was developed to …
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Psychosocial Support Needs and Preferences Among Family Caregivers of ICU Patients with Severe Acute Brain Injury: A Qualitative Thematic Analysis
… of patients with SABI, do not demonstrate long-term efficacy, and may increase caregiver burden. In this study, we explored the needs and preferences for psychosocial services among SABI caregivers to inform the development and adaptation of interventions to reduce their emotional distress, …
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Bayesian Adaptive Clinical Trial Design
… schedule is of great importance to maximize efficacy and safety of targeted therapies and immunotherapies. The US Food and Drug Administration (FDA) Oncology Center of Excellence recently launched Project Optimus to accelerate this paradigm shift. In addition, once the OBD and recommended …
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Improving the Safety and Efficacy of AAV Gene Therapy for Hemophilia A
… to outstanding questions regarding safety and long-term efficacy after adeno-associated viral (AAV) vector delivery of the F8 gene to hepatocytes. To address questions of safety, we treated privately owned dogs with a liver directed AAV serotype 8 vector encapsidating a canine F8 gene. These …
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Biological wastes as plant growth substrate amendments
… that further trials are required to confirm long-term efficacy. The second part of the research investigated the persistence of enteric bacteria in raw salad vegetables using model food poisoning isolates. In clinical investigations plants are sampled for bacterial contamination but no …
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Dietary interventions and strategies to reduce sodium consumption and volume overload in hemodialysis patients
… sodium diet, which has contributed to the poor efficacy of dietary counseling to reduce sodium intake in the renal nutrition literature. Home delivery of low-sodium meals is an alternative to low-sodium counseling that bypasses many of the barriers to reducing sodium intake and reducing acute …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
… heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most effective targets are likely to be factors essential for maintaining ccRCC cell phenotypes and survival across all tumour …
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A Pedagogical Approach to Create and Assess Domain-Specific Data Science Learning Materials in the Biomedical Sciences
… data science workshop materials for short term and long term efficacy. (3) pilot and identify at how to manage real-time feedback within a data coding teaching session to drive better learner motivation and engagement. The key findings from this dissertation suggests using a structured …
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