Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"long non coding RNA"”.
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Role of long non-coding RNA in atherosclerosis
… still needed to address this global epidemic. Long noncoding RNAs (lncRNAs) are an emergent class of molecules with diverse functional roles, widely expressed in human physiology and disease. Although some lncRNAs have already been identified in cardiovascular disease, their potential as novel …
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The role of long non-coding RNA LINC00673 in lung tumorigenesis
… networks involving multiple cellular species. Non-coding RNAs (ncRNAs) are a class of RNA molecules varying in size, biogenesis and mechanism of action that have established themselves as key regulators of cellular behaviour. This project explores the roles of long non-coding RNA (lncRNA) in …
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ZFAS1: a long non-coding RNA with novel implications for ribosome function
Long non-coding RNAs (lncRNAs) are a class of pervasively transcribed non-coding transcripts, regulating gene expression at both the transcriptional and post transcriptional levels. Many lncRNAs exhibit altered expression in diseases processes. Breast cancers show deregulated expression of lncRNAs, …
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In Vivo Functional Significance of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome
<p>Long non-coding RNAs form the largest part of the mammalian non-coding transcriptome and control gene expression at various levels including chromatin modification, transcriptional and post-transcriptional processing. Although the underlying molecular mechanisms are not yet entirely understood, …
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The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
… UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of …
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LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
… regulated by various modulators including long non-coding RNAs (lncRNAs), which influence gene expression and cardiac cell fate. This thesis focuses on verifying and characterizing of one key lncRNA, VENTHEART (VHRT), which was identified as one of the top upregulated markers in …
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New Microfluidic Technologies for Studying Histone Modifications and Long Non-Coding RNA Bindings
… as DNA methylation, histone modification, and non-coding RNA interaction, play critical roles in cell differentiation and disease processes. The conventional approach requires the use of a few million or more cells as starting material. However, such quantity is not available when samples from …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
… role of MALAT1, a highly conserved nuclear lncRNA, in chronic diabetic complications affecting the heart and kidneys, specifically with respect to inflammatory cytokine production. Endothelial cells, exposed to various glucose levels, and MALAT1 knockout mice and controls, with or without …
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Long non-coding RNA Hsr-omega provides scaffolding for the nuclear domain B-body
… We hypothesized that the B-body must contain an RNA scaffold because Bru association with B-bodies is RNase-sensitive. Using Immuno-FISH, we identified a lncRNA co-localizing with the B-body; this RNA is the <em>heat shock RNA omega</em> (<em>hsrω</em>). Next, we tested the requirement of protein …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… at different times of the DDR. Regulation of 3’ mRNA processing allows fast control of gene expression transcriptome wide as it is a ubiquitous co-transcriptional processing step. One powerful method widely used to control gene expression is alternative polyadenylation (APA). Approximately 70% of …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… Despite therapeutic advances that have prolonged life, MI remains a leading cause of death worldwide and imparts a significant economic burden. The advancement of treatments to improve cardiac repair post-MI requires the discovery of new targeted treatment strategies. …
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A matter of time: assessing the biological functions of oscillating natural antisense long non-coding RNA transcripts
… The roles of oscillating protein-coding transcripts have been well studied in theplant circadian clock, however recent research has identified that the transcription of long nonprotein coding RNAs can also oscillate in a diurnal manner. Here we document two circadianregulated …
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The Novel Long Non-Coding RNA Nostrill Regulates Intestinal Epithelial Defense Against Cryptosporidium parvum and Modulates Microglial-Mediated Neurotoxicity
Increasing evidence supports the role of long non-coding RNAs (lncRNAs) as critical regulators of diverse cellular processes, however, their role in antimicrobial host defense and inflammatory regulation is incompletely understood. In this study, we hypothesize that a novel lncRNA candidate broadly …
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Exploring the Role of Long Non-Coding RNA in Neural Stem Cell Reactivation from Quiescence: A Functional Genomics Approach
Given the proposed role of long non-coding RNA (lncRNA) in fine-tuning large-scale genomic responses to stimuli and cell-fate transitions, previous members of the Brand lab compared genome-wide changes in DNA polymerase II occupancy at lncRNA loci during Drosophila melanogaster neural stem cell …
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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
It has been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that …
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Role of lncRNA in cancer development and progression
PART1, TITLE: A p53-inducible long non-coding RNA PICART1 mediating cancer cell proliferation and migration. Long non-coding RNAs (lncRNAs) function in the development and progression of cancer, but only a small portion of lncRNAs are characterized thus far. A novel lncRNA transcript with 2.53 kb …
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THE ROLE OF INTEGRATOR SUBUNIT 11 IN PROMOTOR-PROXIMAL ATTENUATION OF PROTEIN CODING GENES
… a 14-subunit protein complex that interacts with RNA polymerase II (RNAPII) in metazoans during transcription of multiple forms of coding and non-coding RNA. Originally described as being responsible for the 3’ cleavage and termination of uridine-rich small nuclear RNA, further roles have been …
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RNA-based therapeutic approaches for FTDP-17
… 2002). This PhD thesis focuses on developing RNA-based therapeutic approaches to address FTDP-17. CHAPTER 1 introduces a broad range of topics such as splicing mechanism, neurodegenerative diseases associated with splice defects, therapeutic tools to modulate such splice defects in the context …
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Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis)
… 3’ transcripts corresponded to annotated Meis2 mRNA transcripts, the 5’ transcript corresponded to an mRNA transcript that did not code for any known protein. The 5’ transcript was thought to be a long non-coding RNA and was termed lncMeis2. In this study Random Amplification of cDNA Ends (RACE) …
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