Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 46 for “"locus coeruleus"”.
-
The role of locus coeruleus norepinephrine in reinforcement learning
… regions, with the exception of the striatum. The locus coeruleus (LC) is a small brainstem nucleus, and the primary source of NE in the brain. LC-NE neurons release NE to regulate baseline arousal and to facilitate a variety of sensory-motor and behavioral functions. Dysfunction in the LC-NE …
-
Sources and Targets of Trophic Factors in the Avian Locus Coeruleus and Oculomotor System
… conditions. The embryonic chick retina-locus coeruleus system was used as a model system to study both volume and wiring transmission routes of nerve growth factor (NGF). We found that NGF could travel from the retinal ganglion cells to the locus coeruleus (LoC) through a relay in the …
-
Actividad del sistema noradrenérgico-locus coeruleus en el dolor neuropático a lo largo del tiempo
… desarrollo de futuros enfoques terapéuticos. El locus coeruleus (LC) es la fuente principal de noradrenalina del Sistema Nervioso Central y se conoce en el campo del dolor su papel en la inhibición descendente de la transmisión dolorosa de tipo aguda y por su participación en el proceso …
-
Angiotensin II modulates glutamate-induced depolarizations and synaptic transmission in rat locus coeruleus neurons in vitro.
… activity and on Glu-induced responses in rat locus coerulus neurons. The action of AII appears to be selective since it had no effect on the depolarizations evoked by acetylcholine (ACh), or by depolarizing current injections. Selectivity is also indicated by the observation that AII had …
-
Locus-coeruleus norepinephrine system function in a developmental animal model of schizophrenia: the socially isolated rat
… were performed on projections of the locus coeruleus norepinephrine system, known to be involved in attentional function, as research on this system is surprisingly sparse. The secondary aim of the study was to address the negative symptoms of schizophrenia using ultrasonic …
-
The connection between the triple network model and locus coeruleus integrity in those exhibiting inattentive symptoms
The locus coeruleus (LC) is a nucleus within the brainstem associated with physiological arousal and attention performance, with altered structure and function previously identified in neurodegenerative disorders. Pathologies related to difficulties with attention have previously been understood …
-
Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
… in stress responsivity. The noradrenergic locus coeruleus (LC), the brain’s main noradrenergic nucleus, together with its projection targets, including the dorsal reticular nucleus (DRt) and the basolateral amygdala (BLA), plays a central role in modulating nociception and anxiety-related …
-
Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… noradrenaline (NA)-producing neurons in the Locus Coeruleus (LC). By tracking the appearance of Lewy bodies in PD, it has been hypothesized (‘Braak hypothesis’) that degeneration ascends through the brain in the caudal-to-rostral direction. Located in the pons, LC neurons are the first …
-
Age and Family History of Alzheimer's Disease and Related Dementias as Predictors of Locus Coeruleus and Salience Network Connectivity
The locus coeruleus (LC) is a nucleus on the brainstem that produces the majority of the norepinephrine in the brain. The LC interacts with the salience network (SN), specifically the dorsal anterior cingulate cortex (dACC) and the insula, to coordinate and direct attention. The LC is a site of …
-
Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
… nervous system differences. Among these, the locus coeruleus (LC), the main noradrenergic nucleus in the brainstem, exhibits pronounced sexual dimorphism in both its structure and function. The LC is a key node in the modulation of pain, arousal, and stress, and its projections reach …
-
Sistema integrado de registro y análisis de la respuesta pupilar en roedores aplicación al estudio del dolor y del locus coeruleus
… la aparición de los trastornos afectivos. El Locus Coeruleus (LC), la principal fuente de síntesis cerebral de noradrenalina emerge como una región clave para estudiar los circuitos cerebrales implicados en esta comorbilidad. Sin embargo, el rol del sistema noradrenérgico-LC en el dolor …
-
Mechanisms of apathy in health and Parkinson's disease
… by ultrahigh field 7T MR imaging of the locus coeruleus. I found that the effect of atomoxetine on patients' prior beliefs varied strongly as a function of locus coeruleus integrity. Specifically, the patients with a more degenerate locus coeruleus benefitted more from treatment by …
-
DEVELOPMENT OF ALZHEIMER'S-LIKE PATHOLOGY IN NON-HUMAN PRIMATES WITH REDUCED LEVELS OF NOREPINEPHRINE
… and cortical brain regions occurs in the locus coeruleus. Impaired function results in reduced availability of norepinephrine. Locus coeruleus degeneration is a well-documented feature of Alzheimer's disease; however, the role of catecholaminergic dysfunction remains unclear. Deregulation …
-
Seizures Cause Long-Lasting Analgesia and Short-Lasting Hyperoxia
… I also examined brain oxygenation in the locus coeruleus – a region involved in the descending modulation of pain – before, during, and after maximal electroconvulsive stimulation-induced seizures. Methods: The nociceptive perception of mice before and after a seizure was measured using …
-
Acting on Behaviorally Relevant Events and the Impact this has on Attention & Memory
… regions. A promising candidate mechanism is the locus coeruleus neuromodulatory system. The third article investigates how, using functional magnetic resonance imaging, methodological decisions will affect characterization of this system's functional connectivity in the brain. In the fourth …
-
Neuropathological findings and staging in dementia
… Furthermore, degeneration of the nucleus locus coeruleus, often seen already macroscopically, generally indicates the diagnoses Lewy body disease (LBD) or AD among the demented, while a preserved locus coeruleus occurs mainly in VaD and frontotemporal lobar degeneration (FTLD). Moreover, …
-
ΤΑ ΠΕΠΤΙΔΙΑ ΣΩΜΑΤΟΣΤΑΤΙΝΗ, ΝΕΥΡΟΤΑΣΙΝΗ ΚΑΙ Β-ΕΝΔΟΡΦΙΝΗ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… NEURONS WERE OBSERVED IN THE LOCUS COERULEUS AND THE PONTINE RETICULAR FORMATION OF THE SHEEP ONLY. (SHORTENED)
-
Intermittent swim stress effects on anxiety behavior
… were assessed at the dorsal raphe nucleus and locus coeruleus, respectively, through immunohistochemistry techniques. Results indicated ISS-induced deficits were noted for social exploration, but not with the open field test. No apparent cellular differences were revealed following the open …
Page 1 of 3