Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"locomotor function"”.
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The effect of prophylactic knee braces on running gait
… to the players because of changes in normal function. This study focused on one of seven criteria for knee braces developed by the American Academy of Orthopedic Surgeons, namely that a brace should not interfere with normal running function in the lower extremity. Subjects with no prior …
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
… it is unclear how disruption of GARP complex function leads to motor neuron degeneration. To better understand the role of Vps54 in motor neuron development, function, and age-related neurodegeneration, we disrupted expression of the Vps54 ortholog in Drosophila and examined the impact on …
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In vivo identification of drug therapeutics for nemaline myopathy
… assays with automated activity monitor to assess locomotor function, statistical analysis of the data using GraphPad Prism, and secondary validation screens to confirm drug efficacy. The preliminary screen identified 56 compounds that significantly improved the swimming behavior in the klhl41b …
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Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury
… treatments that can improve recovery of function in SCI patients. Many therapeutic compounds have shown promise in preclinical models of SCI, but all of these have fallen short in clinical trials.</p> <p>P-glycoprotein (Pgp) is an active transporter expressed on capillary endothelial cell …
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Traumatic Brain Injury As An Environmental Risk Factor For Neurodegeneration: Elucidating Causal Mechanisms With Drosophila
… ataxia, followed by a sustained loss in locomotor function, a progressive brain degeneration that is characterized by vacuoles, and a dose-dependent reduction in lifespan. The severe form of dTBI is characterized by early-onset cognitive loss, transient deficits in the blood-brain barrier …
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Cerebral Palsy and Rhizotomy: A ten year follow-up study with Gait Analysis
… the three-year follow-up study, suggesting that functional changes acquired due to rhizotomy were of long term duration. The spatial-temporal parameters, however, did differ significantly from the normal range. Although this finding may have been influenced by the environment and subject …
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… expression of IL-1â and IL-1ra affected post-SCI locomotor function, recombinant IL-1â and IL-1ra were administered to glutamate-exposed spinal cords. The Basso-Beattie-Bresnahan (BBB) test of functional recovery demonstrated that IL-1â impaired rat locomotive ability and that IL-1ra improved the …
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Paw Print Gait Analysis in Rats with Spinal Cord Injury
… approaches to gait analysis, such as open field locomotor scoring and automated paw print analysis. Until recently, both of these approaches allowed the animal to walk at a self-selected speed. To further characterize gait recovery, the DigiGait system was developed to obtain video of paw prints …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… including analgesia, tolerance, hyperalgesia, locomotor function and reinforcement.<br/><br/>We generated FC in post-natal day (PD) 2-9 mice and investigated their nociception and morphine analgesia, tolerance, hyperalgesia, hyperlocomotion and reinforcement at adulthood. To do this we utilised …
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Evolutionary dynamics of avian and non-avian limb morphology
… extrinsic factors (e.g., two traits of the same functional apparatus). Flight styles vary greatly in birds from flightless birds with little or no functional influence to strong flappers with great functional influence. This variation allows specific tests of the expected magnitude of functional …