Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"local translation"”.
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Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq
Subcellular localization of RNAs is a ubiquitous and evolutionarily conserved process that provides an additional layer of transcriptome organization promoting coordinated control of gene expression in both space and time. It has been shown to contribute to processes ranging from cell fate …
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Axonal Translation and Links to Neuropathies
… regulation of the axonal proteome by local protein synthesis (LPS) plays a critical role in neuronal wiring and axon survival, raising the intriguing possibility that some neurological disorders involve LPS dysfunction. To visualise LPS in situ, I optimised multiple imaging techniques …
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PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… early, induction part of L-LTP, which depends on local translation of pre-existing mRNAs in the dendrites, and blocks the late, maintenance part of L-LTP, which depends on new gene transcription and translation of newly synthesized mRNAs. The proteasome is also known to have non-proteolytic roles …
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Decoding details : integrating physics of assembly in discrete element structures
… step of the assembly sequence to show global and local instability. Local translation freedom (LTF) analysis shows the range of feasible assembly directions. Detailing knowledge is studied and encoded in shape rules to create a detail grammar. Real time visual feedback of the constraints informs …
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The cue induced axonal nascent proteome and its translational control mechanisms in neural wiring
… full landscape of proteomic changes and their translational control mechanisms remain unknown. The ability to investigate the nascent proteome on subcellular compartments has been hampered by the low sensitivity of existing methodology on quantity-limited samples combined with the difficulty of …
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Towards understanding the mechanisms behind mRNA localisation in growing axons
During embryonic nervous system assembly, mRNA localisation is precisely regulated in growing axons, affording subcellular autonomy by allowing controlled protein expression in space and time. Different sets of mRNAs exhibit different localisation patterns across the axon. Little is known, however, …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… act in functional opposition to regulate local translation of synaptic mRNAs. Fragile X is the most common form of inherited intellectual disability and autism, and is expressed by a loss of FMRP. Previous studies have implicated mGluR5 in the pathogenesis of the disease, but a crucial …
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miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
… nucleotides long, which can reversibly repress local translation in dendrites. By responding to external cues sensed by dendritic filopodia, they participate in the key decision-making processes in developing dendrites: where and how to grow. This study focuses on the role of miR-125b, a brain …
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Development and application of optical microscopy tools for the study of axon guidance
… pathways are initiated, one of which induces local protein synthesis (LPS), a key process to enable rapid navigational responses to guidance cues. Impairments of axon guidance and LPS are associated with several neurological disorders. In this thesis, state-of-the-art optical microscopy-based …
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The role of the RNA-binding protein FUS in axonal organisation and disease
… change its phase transitions and subcellular localisation. This is known to compromise axonal local protein synthesis (LPS), but it is not well-understood which critical LPS-dependent processes are affected. This is important, as these processes represent potential therapeutic targets. In my …