Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"local recurrence"”.
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Aspects on local recurrence after rectal cancer surgery
Background: Local recurrence after rectal cancer surgery has a profound impact on affected patients’ lives. The overall aim of this thesis was to acquire a deeper understanding of local recurrence after rectal cancer surgery, with a long-term hope of minimising the incidence and mitigating the …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
Local recurrence has always been a challenging problem following rectal cancer surgery, desite of the advances in surgical technique(TME) as well as adjuvant therapy(preoperative CCRT). There is a need for better prognostic markers due to the varieties of treatment response within same …
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Five-year review of breast-conserving therapy (BCT) for breast carcinoma: Surgical margins, re-excision and local recurrence in a single tertiary center
… for early breast cancer. It is the wide local excision of the tumour usually followed by radiation treatment to the breast. It is the mainstay treatment for carefully selected patients with early breast cancer presenting to the Groote Schuur Hospital's Oncology and Endocrine Surgical …
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Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life
… and non-radical surgery and therefor improve local cancer control and decrease rates of local recurrences as compared to standard APE. This thesis aims to investigate if the oncological outcome of ELAPE is superior to standard APE and to explore the association between patient reported …
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Use of Human Reliability Analysis to evaluate surgical technique for rectal cancer
… training programme in Stockholm which reduced local recurrence rates of cancer by 50%. It is generally accepted that good surgical technique is the enactment of a series of positive surgical actions, and the avoidance of errors. However, the constituents of good surgical technique for rectal …
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Immunocytochemistry Of Rectal Cancer Circumferential Margins In The Assessment Of Micrometastatic Disease
… disease has been shown to be associated with recurrence of the disease. However, there is no evidence of investigation into the micrometastastic disease at the circumferential margins of rectal cancers. Therefore, this study was aimed at the assessment of micrometastatic disease in the …
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Prognostic Factors in Transitional Cell Carcinoma of Upper Urinary Tract after Radical Nephroureterectomy
… of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed using univariate and multivariate analysis. Results : Of total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died during the …
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Cellular and molecular mechanisms of response to, and recurrence following, breast radiotherapy
This thesis explores response to, and recurrence following, radiotherapy in primary breast cancer within three clinical trials investigating aspects of radiation management: the IMPORT trials, IMPORT LOW and IMPORT HIGH, and the NeoRT trial. Clinical outcomes from the NeoRT trial are described as …
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Modular prosthetic reconstruction for primary bone tumours of the distal tibia in ten patients
… a mean age of 31 (12-75) years. Two patients had local recurrence treated with a BKA and one other patient died of metastases three years postoperatively. At a mean follow-up of three years, the remaining eight patients had a mean MSTS score of 83% (67–93%). There were no radiological signs of …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… dogs and humans. Treatment failures resulting in local recurrence and death remain common in tumors of high grade, prompting a need for additional therapeutic options that are both effective and affordable. Genetic modification of the LaSota strain of Newcastle Disease Virus (rLAS) has allowed the …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver and particularly in the tumor proximity. This study aims to investigate primary human hepatocytes culture obtained from liver specimens of patients affected …
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Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence.
… (HR 3.2), and the latter also correlated with local recurrence (LR). In comparison, histological malignancy grade, tumor size, and depth were not of independent prognostic value. When TMA was performed from the peripheral tumor growth zone, the IHC expression of Ki-67 (HR 1.9), ß-catenin (HR …
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Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
… the management of rectal cancer have reduced the local recurrence (LR) rate and improved survival. To improve the outcome further, identification of prognostic and predictive factors is important for optimal, personalised neoadjuvant/adjuvant treatment and follow-up strategies. This thesis …
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Surveillance Imaging Following Curative-Intent Surgery for Non-Small Cell Lung Carcinoma: A Systematic Review
… carcinoma (NSCLC), patients remain at risk for recurrence of lung cancer or for development of second primary lung cancer (SPLC). While periodic surveillance may detect early stage recurrence or SPLC, the effectiveness of surveillance has not been established. Additionally, current practice …
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Values and Preferences of Patients with Small Renal Masses: Integrating Evidence and Patient Perspectives
… (overall mortality, cancer-specific mortality, local recurrence, metastasis). Methods emphasized applicability to decisions: QUIPS for risk of bias; GRADE adapted for prognosis (including a decision-threshold approach to imprecision); ICEMAN to guard against over-interpretation of subgroup …
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Anorektal-, Blasen und Sexualfunktionsstörungen sowie Lebensqualität bei Frauen nach Rektumresektion im Vergleich zur Kolonresektion bei Karzinom
… age over 70 years at time of the survey, local recurrence, anastomotic insufficiency, radiotherypy, presence of colostomy, immobility, neural disease affecting pelvic function. The study group (TAR with TME) included 15 women, the control group (colonic resection) 11 women. The …
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Development of a Platform for Surface Enhanced Raman Scattering Endoscopy
… left in-situ, and consequent improvement in local recurrence rates. By performing such early-stage resections endoscopically, patients may benefit from lower morbidity rates as compared to traditional open approaches. Molecular imaging using surface enhanced Raman scattering (SERS) …
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Evaluating the functional effects, morbidity, recurrence, survival and quality of life after curative treatment for rectal cancer
… thesis finally examines the long term morbidity, local recurrence and survival associated with radiotherapy and provides a protocol for future studies to better evaluate the effects of rectal cancer treatment. Patients treated for rectal cancer have greater rectal functional impairment compared to …
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Nanoparticle preconditioning for enhanced thermal therapies in cancer.
… delivery of molecular adjuvants to enhance local cancer therapy. One important form of local cancer treatment that suffers from local recurrence and distant metastases is thermal therapy. A new concept involving the use of nanoparticle-delivered adjuvants to `precondition' (alter the …
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Interstitial laser thermotherapy (ILT) of breast cancer - Methodology and immunological responce
… thermotherapy (ILT) is an attractive form of local therapy against cancer because of its anti-tumor immune activity. The aim of this work was to evaluate ILT in breast cancer with respect to technique, changes in tissue immunocompetent cells and effect on prognosis. The method is dependent on …
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