Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"lncRNAs"”.
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Role of microRNA-host-lncRNAs in cell cycle
Made available in DSpace on 2020-08-27T00:46:52Z (GMT). No. of bitstreams: 2 SUN-DISSERTATION-2020.pdf: 9175277 bytes, checksum: e2efccee2ecdb753df410d65867ed198 (MD5) LICENSE.txt: 4206 bytes, checksum: d9400be8634f345516a8365c493c941a (MD5) Previous issue date: 2020-03-17
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Caracterització estructural i funcional de long non-coding RNAs (lncRNAs) en nematodes
… de l'expressió genètica i que tots els gens dels lncRNAs amb els quals interaccionen es troben en coordenades allunyades.
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Applications of forward genetic screens to LncRNAs, cancer immunotherapy, and cellular engineering
Forward genetic screens are powerful tools for the unbiased discovery and functional characterization of specific genetic elements associated with a phenotype of interest. By perturbing thousands of genes simultaneously and selecting for a desired phenotype, genetic features can be systematically …
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Host lncRNAs recognize invading bacteria and aid against infection by associating with polysomes
… picture is still sketchy at best. Surprisingly, lncRNAs have recently been found to associate with ribosomes and polysomes; however, to date no research exists that addresses their role in translation regulation upon bacterial infection. AIM: The key question I wanted to answer during my PhD is …
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Finding lncRNAs in bone marrow and fetal liver erythroid progenitor cells in mice
Red blood cell development is crucial to the survival of all mammals and occurs primarily in the liver during embryogenesis and then in the bone marrow during adulthood. In spite of the different microenvironments of the liver and bone marrow, current research shows that the majority of …
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Characterization of transcription factors and LncRNAs involved in the development of the bat wing
… Isoform characterization to validate the two LncRNAs, was performed on cDNA a CS 18L embryo. The cloned transcripts identified a new set of alternatively spliced isoforms for both LncRNAs. Unusual RNA-seq tracks in the HoxA10 locus were investigated using qPCR. It was discovered this region is …
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Estudio de los lncRNAs MDL1 y MDL1AS en diferentes tipos de tumores y su relevancia clínica en adenocarcinoma rectal
… In this context, long non-coding RNAs (lncRNAs) play a prominent role, and new lncRNAs are continuously being discovered, as well as new functions for those we already know. In 2018, Gao et al. identified two new mitochondrial lncRNAs in the region known as D-loop, which they named …
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… RNAs, particularly long non-coding RNAs (lncRNAs), are still being elucidated, with new functions continuously emerging as the filed advances. In recent years, several technologies have been developed to study RNA-chromatin interactions at a genome-wide scale, including RNA And DNA …
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Enabling the in vitro study of long noncoding RNAs to understand their role in Plasmodium falciparum
Long noncoding RNAs (lncRNAs) have been identified in *Plasmodium falciparum*, the parasitic cause for life-threatening malaria, yet their role remains largely undiscovered. Through interactions with nucleic acids and proteins, lncRNAs can modulate gene expression at the transcriptional, …
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LncRNA discovery in the Listeria monocytogenes infection model
… of evidence indicates that long noncoding RNAs (lncRNAs), the most abundant noncoding RNA (ncRNA) species of the pervasively transcribed mammalain genome, have functional roles in the gene regulation of an array of cellular processes. These observations have since discredited the long standing …
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The Regulation and Evolution of long, noncoding RNA Transcription
… production of thousands of long, noncoding RNAs (lncRNAs, > 200 basepairs), which are distinct from more traditional noncoding RNAs such as transfer RNAs or ribosomal RNAs. This striking finding is observed across all eukaryotes, from humans to budding yeast. It was once thought that these lncRNAs …
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Caste-Specific Expression Of Coding And Noncoding Genes In Ant Brains
… gene expression. Long untranslated transcripts (lncRNAs), are one means by which epigenetics asserts control over gene regulation in a variety of organisms, including Harpegnathos. Technologies for better annotation and functional classification of lncRNAs have provided insight into biochemical …
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Genome regulation by long noncoding RNAs
… also produce thousands of long non-coding RNAs (lncRNAs), some of which are now known to play essential roles in diverse biological processes including cellular differentiation and human disease. Recent studies show that many lncRNAs localize to the nucleus and interact with chromatin regulatory …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
… and tRNAs), as well as long non-coding RNAs (lncRNAs), which are >200nt and resemble mRNAs in their biogenesis. Although the functions of the vast majority of lncRNAs remain unknown, many are tissue- and developmental stage-specific, suggesting roles in lineage-specific development. We …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… are classified as long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides, but very few have been functionally characterized. Here, I detail a journey of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, beginning from the …
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Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
… the small RNAs (smRNAs) and long ncRNAs (lncRNAs). Studies have shown that ncRNAs can have very important regulatory functions such as the establishment and maintenance of the epigenetic architecture of eukaryotic genomes. However, these studies have only revealed the surface of ncRNAs’ …
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Identifiying Casc15 as a novel regulator of progenitors’ proliferation and neuronal migration in the developing neocortex
… haben sich lange nicht-kodierende RNAs (lncRNAs) als attraktive Ziele in der Entwicklungsbiologie dargestellt. Diese Moleküle haben unsere Wahrnehmung von der funktionalen Einheit einer Zelle revolutioniert, da sie bekannt dafür sind, deren Funktion mittels ihrer RNA Struktur auszuüben. …
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Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
… in CHARGE syndrome. To understand the role of lncRNAs in CNS myelination, we establish dynamic expression profiles of lncRNAs at different stages of oligodendrocyte development and uncover a cohort of stage-specific oligodendrocyte-restricted lncRNAs including a conserved chromatinassociated …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… gained attention, with long non-coding RNAs (lncRNAs) as potential targets due to their emerging roles in pathogenic immune responses. We previously performed cap analysis gene expression (CAGE) transcriptomics on IFN-γ stimulated (classically activated) and IL-4/IL-13 stimulated …
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Role of long non-coding RNAs in breast cancer progression
… (ncRNAs), including thousands of long ncRNAs (lncRNAs). At present, we do not know the biological function of majority of these lncRNAs. MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a lncRNA which its expression is deregulated in various tumors, including breast cancer. …
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