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Showing 1 to 9 of 9 for “"liver tissue engineering"”.
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The Role of Biomechanics in Liver Tissue Engineering
The field of liver bioengineering aims to generate functioning liver tissue in the laboratory in order to study complicated processes such as development, disease, cancer, drug metabolism, or even to engineer organs that can be implanted in patients. One approach in liver tissue engineering is to …
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Development of simple 3D-printed scaffolds for liver tissue engineering
One solution to the increasing need for liver transplants is to grow implantable liver tissue in the lab. A tissue-engineered liver for transplantation will require complex structures to support cell differentiation and integration with surrounding vasculature. Recent developments in 3D-printing …
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A THREE DIMENSIONAL MODEL OF HUMAN HEPATO-BILIARY ORGANOGENESIS
In recent years, tissue engineering strategies have emerged aimed at generating functional liver tissue by using decellularized liver scaffolds repopulated with liver cells. The quest continues for identifying the best cell source for liver tissue engineering, but one cell source in particular, …
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Engineering human hepatic organoids for in vitro liver modeling and implantable cell therapies
The adult liver performs hundreds of life-sustaining functions while also exhibiting a miraculous capacity to regenerate, but methods to expand primary hepatic cells in vitro while supporting their phenotype and function remain elusive. Organoid culture has successfully grown dozens of otherwise …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… data for preclinical evaluations of drug-induced liver injury and cardiotoxicity, speeding up the notoriously lengthy and inefficient drug development pipeline, as well as fundamental investigations into stem cell behavior and cell-cell interactions. Tissue engineering is also increasingly used …
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Delineating the interplay of biomechanical cues with cell-cell signaling and epigenetics in liver differentiation and fibrosis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Developing a clinically applicable hydrogel for the treatment of liver disease
Liver disease is a growing clinical burden worldwide. International rates of obesity and the incidence of alcohol abuse in Europe contribute significantly to chronic liver disease. Approximately a quarter of the world's population is estimated to have non-alcoholic fatty liver disease, and alcohol …
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Identifcation and stablization of a novel 3D hepatocyte monolayer for hepatocyte-based applications
An interesting morphological stage before the formation of 3D spheroids was discovered when the hepatocytes attach to the substrata as monolayer but exhibiting many characteristics of the 3D spheroids, but without the limitations of the 3D spheroids. We coined the name of b 3D hepatocyte monolayerb …
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Investigating the role of geometry, mechanics, and microenvironmental cues on liver progenitor cell differentiation
… in the microenvironment that direct cells and tissue fates. This work focuses on developing and using such systems to investigate how mechanical characteristics impact liver progenitor cell differentiation. In this dissertation, I will introduce and review relevant concepts of mechanobiology …