Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"liver regeneration"”.
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Manipulating macrophages to enhance liver regeneration
Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic …
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Liver regeneration by hepatic progenitor cells
The liver is the largest solid organ in the body and is frequently the site of injury. During disease, liver injury is usually compensated for by exceptionally efficient regeneration which occurs both from differentiated epithelia and also from an undifferentiated cell population with stem cell …
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Cellular and molecular mechanisms of liver regeneration
Improved understanding of how the liver regenerates would be of great value, particularly given the dearth of therapies for end-stage liver disease. Currently, the only effective treatment for total liver failure is transplantation. Such an invasive, costly and specialised intervention is unable to …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
<p>p53 MAINTAINS HEPATIC CELL IDENTITY DURING LIVER REGENERATION</p> <p>Zeynep Hande Coban Akdemir, B.S.,M.A.</p> <p>Advisory Professor: Michelle Craig Barton, Ph.D.</p> <p>p53 is a tumor suppressor that has been well studied in tumor-derived, cultured cells. However, its functions in normal …
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Potential commercialization of a collagen-GAG scaffold for liver regeneration
… glycosaminoglycan to help regenerate cirrhotic liver was analyzed and a business plan and model were created. Using a lypholization technique, a bulk-sized and highly porous scaffold is created. It is then inserted into the hole created by the excised liver scar tissue. By blocking contraction …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
Liver regeneration is orchestrated by a series of autocrine and paracrine cues that function to restore hepatic tissue, however the precise cellular and molecular mechanisms that regulate these signaling events are poorly understood. Recent evidence demonstrates that hepatocyte proliferation …
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The role of Arid1a and Tet1 in ductal cell-driven liver regeneration
… role of Arid1a and Tet1 in ductal cell-driven regeneration Author: Mikel Alexander Mckie The liver has several robust and potent mechanisms of repair after damage despite slow homeostatic turnover. In cases of extreme toxic damage, where the hepatocyte compartment is severely compromised and …
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ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial damage …
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Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
… besitzt die einzigartige Fähigkeit der Selbstregeneration nach Schädigung. Adulte Hepatozyten sind in der Lage, in der normalen Leber, ein perfektes Gleichgewicht zwischen Zellzuwachs und Zelluntergang aufrecht zu erhalten. Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit zur …
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A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
Living donor liver transplantation (LDLT) is now well established and performed on a routine basis in many major centres around the world. LDLT is feasible because of the capacity of both the remnant donor liver and the transplanted partial liver to undergo liver regeneration. However it has been …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… has been shown to promote hepatic repair and regeneration during liver ischemia/reperfusion injury, but its effects in APAP hepatotoxicity is unknown. The primary objective of this dissertation was to explore the role of netrin-1 and its receptor adenosine A2B in APAP hepatotoxicity. In the …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… However, the mechanism of p53/p73 function in liver remains poorly characterized. Here, the model of mouse liver regeneration is used to identify new target genes for p53/p73 in normal quiescent vs. proliferating cells. In response to surgical removal of ~2/3 of liver mass (partial hepatectomy, …
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O-GlcNAcylation: A key regulator of hepatic proliferation and differentiation
… physiological processes, including development, regeneration, inflammation, proliferation, metabolism, and pathogenesis of various diseases. O-GlcNAcylation is regulated by two enzymes, O-GlcNAc transferase (OGT), which adds a glucosamine sugar on serine or threonine residues of proteins, and …
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
… maturation is not well understood. The mammalian liver is a major metabolic organ responsible for a variety of functions and has an exceptional capacity for regeneration. Liver undergoes dramatic transitions with regards to structure and function during postnatal development and during …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… transcription factor, attenuates liver regeneration in vivo when activated by its prototypical agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) following 70% partial hepatectomy (PH). One reported target of the AhR that may account for suppression of the regenerative response is …
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A Rhapsody on the Aryl Hydrocarbon Receptor: Molecular and Environmental Health Insights Through Novel and Canonical Signaling Pathways
… role of the AhR in cellular replication during liver regeneration. Based on our findings, we then set out to assess transcriptional targets of the AhR in the mouse liver following exposure to 2,3,7,8-tetrechlorodibenzo-p-dioxin. Finally, given the toxicities with which the AhR is associated, we …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… is associated with rapid proliferation and regeneration of the remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85ƒÑ regulatory and a p110ƒÑ catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in …
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