Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"liver regeneration"”.
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Liver regeneration by hepatic progenitor cells
The liver is the largest solid organ in the body and is frequently the site of injury. During disease, liver injury is usually compensated for by exceptionally efficient regeneration which occurs both from differentiated epithelia and also from an undifferentiated cell population with stem cell …
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Manipulating macrophages to enhance liver regeneration
Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic …
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Cellular and molecular mechanisms of liver regeneration
Improved understanding of how the liver regenerates would be of great value, particularly given the dearth of therapies for end-stage liver disease. Currently, the only effective treatment for total liver failure is transplantation. Such an invasive, costly and specialised intervention is unable to …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
<p>p53 MAINTAINS HEPATIC CELL IDENTITY DURING LIVER REGENERATION</p> <p>Zeynep Hande Coban Akdemir, B.S.,M.A.</p> <p>Advisory Professor: Michelle Craig Barton, Ph.D.</p> <p>p53 is a tumor suppressor that has been well studied in tumor-derived, cultured cells. However, its functions in normal …
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Role of the IKK complex during liver regeneration
The transcription factor NF-kB is essential for liver homeostasis. The IKK complex (composed by two catalytic subunits IKK1 and IKK2 and a regulatory subunit Nemo) tightly regulates NF-kB activity. In the present work, we modulated NF-kB activity in the liver by using hepatocyte-specific IKK2 …
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Potential commercialization of a collagen-GAG scaffold for liver regeneration
… glycosaminoglycan to help regenerate cirrhotic liver was analyzed and a business plan and model were created. Using a lypholization technique, a bulk-sized and highly porous scaffold is created. It is then inserted into the hole created by the excised liver scar tissue. By blocking contraction …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
Liver regeneration is orchestrated by a series of autocrine and paracrine cues that function to restore hepatic tissue, however the precise cellular and molecular mechanisms that regulate these signaling events are poorly understood. Recent evidence demonstrates that hepatocyte proliferation …
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The role of Arid1a and Tet1 in ductal cell-driven liver regeneration
… role of Arid1a and Tet1 in ductal cell-driven regeneration Author: Mikel Alexander Mckie The liver has several robust and potent mechanisms of repair after damage despite slow homeostatic turnover. In cases of extreme toxic damage, where the hepatocyte compartment is severely compromised and …
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Molecular analysis of the role of Caspase-8 during liver regeneration and tumorigenesis
… signaling is crucial for the priming phase of liver regeneration following partial hepatectomy (PH) which directly contributes to gene activation of Cyclin D via NF-kappaB, c-Jun/ AP-1 and E2F1. The aim of the present study was to investigate the consequences of Caspase-8 deletion for TNF …
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ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial damage …
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Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
… besitzt die einzigartige Fähigkeit der Selbstregeneration nach Schädigung. Adulte Hepatozyten sind in der Lage, in der normalen Leber, ein perfektes Gleichgewicht zwischen Zellzuwachs und Zelluntergang aufrecht zu erhalten. Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit zur …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… in hepatocytes was investigated in terms of liver regeneration, liver dependent iron homeostasis and gram positive sepsis. Therefore, mice either defective in hepatocyte-specific gp130-dependent Ras/Erk or STAT activation were generated to define the role of these signalling pathways. These …
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A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
Living donor liver transplantation (LDLT) is now well established and performed on a routine basis in many major centres around the world. LDLT is feasible because of the capacity of both the remnant donor liver and the transplanted partial liver to undergo liver regeneration. However it has been …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… has been shown to promote hepatic repair and regeneration during liver ischemia/reperfusion injury, but its effects in APAP hepatotoxicity is unknown. The primary objective of this dissertation was to explore the role of netrin-1 and its receptor adenosine A2B in APAP hepatotoxicity. In the …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… However, the mechanism of p53/p73 function in liver remains poorly characterized. Here, the model of mouse liver regeneration is used to identify new target genes for p53/p73 in normal quiescent vs. proliferating cells. In response to surgical removal of ~2/3 of liver mass (partial hepatectomy, …
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O-GlcNAcylation: A key regulator of hepatic proliferation and differentiation
… physiological processes, including development, regeneration, inflammation, proliferation, metabolism, and pathogenesis of various diseases. O-GlcNAcylation is regulated by two enzymes, O-GlcNAc transferase (OGT), which adds a glucosamine sugar on serine or threonine residues of proteins, and …
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
… maturation is not well understood. The mammalian liver is a major metabolic organ responsible for a variety of functions and has an exceptional capacity for regeneration. Liver undergoes dramatic transitions with regards to structure and function during postnatal development and during …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… that cyclin E1-/- deletion results in normal liver regeneration with slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression of cyclin E1 and prolonged cdk2 kinase activity leading to earlier and sustained DNA …
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