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Showing 1 to 2 of 2 for “"liver progenitor differentiation"”.
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… microenvironmental regulation in the context of liver progenitor differentiation and lung tumor cell drug responses. Liver progenitor differentiation was found to be combinatorially regulated by Notch, TGFβ signaling as well as interactions with ECM proteins. The Notch ligands Jag1 and Dll1 were …