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Showing 1 to 7 of 7 for “"liver organoids"”.
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Human Liver Organoids as models for investigating drug-induced liver injury
The liver is the primary organ involved in drug detoxification, hence being highly exposed to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of …
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PNPLA3 P.I148M VARIANT INCREASES LIPID DROPLETS NUMBER AND SIZE IN PATIENT-DERIVED LIVER ORGANOIDS
… determinant of metabolic associated steatotic liver disease (MASLD). To this day, this association still lacks a molecular characterization, due to the lack of comprehensive human models. To overcome this gap in knowledge, we generated patient-derived human liver organoids (HLOs) and studied …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
Introduction: The liver is an essential organ in the body responsible for the synthesis of serum proteins, biotransformation, and detoxification of xenobiotic drugs. Drug cytotoxicity studies have been conducted using cancer-derived cell lines which are inferior. In the present study, we developed …
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
Primary liver cancer (PLC) is the second most common cause of cancer death worldwide, preceded only by lung cancer. Current models for PLC either fail to fully recapitulate tumour histology and architecture or are expensive, time consuming and do not allow for personalised drug testing. During the …
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IMPLEMENTATION OF 3D CELLULAR MODELS FOR DRUG AND TOXIN TESTING IN HEALTHY AND CANCEROUS TISSUE
… we employed bioengineered 3D liv er and cardiac organoids biofabricated from multiple physiologically relevant human cell groups to represent healthy tissue , and tumor organoids derived from colorectal cancer cells from established cell lines to screen multiple materials for toxic effect, …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
It has been proposed that liver regeneration in chronic liver disease, such as metabolic dysfunction-associated steatotic liver disease, previously known as non-alcoholic fatty liver disease, is driven by hepatocyte renewal in the early stages, but when hepatocyte proliferation is impaired due to …