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Showing 1 to 7 of 7 for “"liver organoid"”.
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QUANTITATIVE DETECTION OF LIVER-RELEVANT BIOMARKERS BY SERS-IMMUNOLABALED GOLD NANOPARTICLES
… gold nanoparticle complex capable of detecting liver organoid biomarkers intended for use in a microfluidic device. Human Serum Albumin (HSA) and α-Glutathione S-Transferase (α-GST) are liver biomarkers that indicate liver health and damage respectively. Herein we demonstrate
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Engineering Organoids for Stem Cell Maturation
The liver is the largest internal organ in the body. It is responsible for performing an array of vital functions, including the filtration of blood, synthesis of different molecules, and metabolism of drugs and toxicants. Hepatocytes, or the main liver cell type, perform most of these functions. …
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Developing a clinically applicable hydrogel for the treatment of liver disease
Liver disease is a growing clinical burden worldwide. International rates of obesity and the incidence of alcohol abuse in Europe contribute significantly to chronic liver disease. Approximately a quarter of the world's population is estimated to have non-alcoholic fatty liver disease, and alcohol …
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Developing disease-state liver models to determine the effects on brain function in vitro
The liver is responsible for filtering and detoxifying harmful chemicals from the body. Because of its role as the barrier between the gut and the circulatory system, and due to the brain’s high perfusion rate, the liver’s function as a regulator for blood composition is highly important for the …
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Engineering human hepatic organoids for in vitro liver modeling and implantable cell therapies
The adult liver performs hundreds of life-sustaining functions while also exhibiting a miraculous capacity to regenerate, but methods to expand primary hepatic cells in vitro while supporting their phenotype and function remain elusive. Organoid culture has successfully grown dozens of otherwise …
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Modelling human liver bud development in vitro
… self-organise into hepatobiliary bud (HepBud) organoids when grown in 3D. This method forms a heterogenous differentiation culture of foregut derivatives which regionalise to form pancreatic, hepatic and biliary progenitors combined with cardiac and endothelial cells. After 3D seeding, these …