Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"liver metastasis"”.
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Orthotopic liver metastasis mouse models of mismatch repair-proficient colorectal cancer recapitulate clinical inefficacy of immune checkpoint blockade
Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Immune checkpoint blockade (ICB) therapy has significantly improved overall survival in several cancer types including melanoma and non-small cell lung cancer. However, patients with mismatch repair-proficient …
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Insights into the role of hepatic stromal cells and the immune checkpoint protein PD-L1 in liver metastases of pancreatic cancer
… survival, largely due to late diagnosis. The liver is the primary metastatic site, yet how the hepatic microenvironment influences disseminated pancreatic ductal epithelial cells (PDEC) remains unclear. While hepatic stellate cells (HSC) dominate physiological liver contexts, hepatic …
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Network Models for Capturing Molecular Feature and Predicting Drug Target for Various Cancers
… further used to capture molecular features among liver metastasis, primary liver cancers and primary colon cancers. Comparisons among these features lead to new understandings of how liver metastasis is similar to its primary and distant cancers. ‘SCN’ is a novel algorithm that incorporates …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… of the primary tumor in the colon followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, arrival at the end organ and finally colonization of …
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Soybean lunasin mediates colon carcinogenesis by inducing apoptosis and preventing outgrowth of metastasis
… human colon cancer cell lines in vitro and a CRC liver metastasis model in vivo. Lunasin caused cytotoxicity to different human colon cancer cells with an IC50 value of 13.0, 21.6, 26.3 and 61.7 µM for KM12L4, RKO, HCT-116 and HT-29 human colon cancer cells, respectively. This cytotoxicity …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… the most common intraocular tumor in adults and liver metastasis is the leading cause of death in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay …
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Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
… of chromosome 20q is frequently associated with liver metastasis. Previous research in our lab identified a gene signature on chromosome 20q associated with colorectal cancer progression. In this study, one of the genes in the signature, the ubiquitin conjugating enzyme UBE2C, was identified …
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Improving Treatment of Local Liver Ablation Therapy With Deep Learning and Biomechanical Modeling
… cancer, and 60-70% of patients will develop liver metastasis. While surgical liver resection of metastasis is the standard of care for treatment with curative intent, it is only avai lable to about 20% of patients. For patients who are not surgical candidates, local percutaneous ablation …
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Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy
Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
… cancers initially metastasize to the liver first. While the prognosis of early-stage cancers is improving, a significant proportion of patients have metastatic disease at the time of diagnosis leading to poor survival outcomes. I focused on colorectal cancer and pancreatic cancer, the …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… NK cells in blood, spleen, bone marrow and liver. Moreover, IL-1R8 deficient NK cells display an increased Interferonγ (IFNγ), Granzyme B and Fas ligand expression and degranulation. IL-18, which is a key regulator of NK cell activities and can be targeted by IL-1R8, was responsible for this …
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Image Quality Optimisation and Dose Management in CT, SPECT/CT, and PET/CT
… maintaining the signal-to-noise ratio in the liver and contrast-to-noise ratio for a hypothetical hypovascular liver metastasis. Subjective image quality was affected by an increased noise level in the images, but was judged to be acceptable in all investigated patient groups except the one …
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Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
… Current therapeutic strategies fail to target metastasis as the genes and mechanisms that regulate this process remain poorly understood. Metastatic colonization is the final step of the metastatic cascade whereby cancer cells form a tumor at a distant site. This final step is the culmination …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… of the leading global health burdens, with the liver being its predominant site of distant metastasis. A significant proportion of patients with colorectal liver metastases (CRLM) are diagnosed with synchronous lesions (sCRLM), identified at or shortly after diagnosis of the primary tumor, a …
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Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients
… where it is used for early detection of metastasis in follow-up of patients having stage II and III disease, and for monitoring response to adjuvant treatment. However there are no reliable prognostic and response predictive biomarkers for CRC. Tumour-associated trypsin inhibitor (TATI) …
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Transcriptome-wide association analysis of survival in colorectal cancer patients
… (Edinburgh, Scotland) as well as 1948 cases with metastasis or locally advanced colorectal adenocarcinoma from the COntinuous versus INtermittent (COIN) as a replication dataset (Cardiff, Wales)). The TWAS aimed to study the association between gene expression and survival outcomes with the help …
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… phenotypes, resulting in tumor invasion and metastasis.To overcome these issues, we developed a novel anti-tumor therapeutic EndoCDfusion protein which linked endostatin (Endo) to cytosine deaminase-uracilvphosphoribosyl transferase (CD). Endo targets unique tumor endothelial cells toprovide …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… site to distant organs, such as bone, lung and liver. Tumor metastasis is responsible for nearly all of the morbidity and mortality associated with BC. Treatments of BC fail in the advanced stage, when metastases have already occurred. To mimic late stage BC in female patients, a mouse model was …
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Understanding liver metabolic effects of estrogens and liver niche-related metabolic changes in metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01