Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"liver metabolism"”.
-
HEPATIC ESTROGEN RECEPTOR ALPHA ACTS AS A MOLECULAR TIMER ALIGNING LIVER METABOLISM TO PREGNANCY PROGRESSION
… nell’eliminazione di sostanze tossiche e nel metabolismo dei farmaci, e gli ormoni sessuali, in particolare gli estrogeni, regolano il metabolismo epatico agendo principalmente attraverso il recettore degli estrogeni α (ERα). ERα regola con precisione il metabolismo del fegato in relazione …
-
Uncovering the role of bile acid signaling in facilitating sex differences during hepatocarcinogenesis and liver metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
-
Impact of body weight gain on liver metabolism and selected fat-soluble vitamins in ponies and horses
… Leber einher, die sogenannte Non-Alcoholic Fatty Liver Disease, welche zu einer hepatozellulären Entzündung führt. Es ist bisher nicht bekannt, ob Adipositas in Equiden auch zu hepatischen Veränderungen führt. Menschliche Fettleibigkeit ist zusätzlich mit systemischer Entzündung und gesteigertem …
-
Hepatic lipid metabolism and peroxisomal beta-oxidation in dairy cows
… to measure peroxisomal $\beta$-oxidation in the liver of cows and to determine the effects of physiological state and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.
-
Advancement of 31P Magnetic Resonance Spectroscopy Using GRAPPA Reconstruction on a 3D Volume
… treatment response to radiation therapy in liver cancer. Liver metabolism correlates with inflammatory and neoplastic liver diseases, which alter the intracellular concentration of phosphorus- 31 (31P) metabolites [1]. It is assumed that such metabolic changes occur prior to physical changes …
-
Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
… deacetylase 3 (HDAC3) is recruited to the mouse liver genome in a circadian manner. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Diurnal recruitment of HDAC3 corresponds to the expression pattern of REV-ERBα, an important component of …
-
Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass effect and a short half-life. Additionally, the frequent oral administration was inconvenient for the large livestock. To overcome these drawbacks, this study aimed to develop an extended-release …
-
The ontogeny of the immune response to sheep erythrocytes and resistance to aflatoxins in chickens
… Heterophilia, lymphopenia and reduced liver metabolism were observed at the 5697 ppb level. Although bursa and thymus weights were smaller in the aflatoxin-fed birds, there was no reduction in their SRBC antibody levels. The second experiment was designed to measure primary and …
-
EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… on transcriptional profile with loss of all liver specific metabolic pathway. Furthermore, we observed how the absence of both the ARID1 proteins characterized a complete loss of H3K4me1 and H3K27Ac histone modifications on all the FoxA2 targets both on promoter and enhancers. Ultimately, …
-
Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism
… including drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug permeability but they lack or have low expression level of drug metabolism enzyme expression such as CYP3A4, which contributes to …
-
Proteomic profiling of Nguni cattle liver tissue using gel and Gel-Free approaches: methodology development and potential applications
… for the protein profiling of Nguni cattle livers. To achieve this several alternative technologies were employed and their outcomes compared namely, two-dimensional electrophoresis, fractionation by solution phase iso-electric focusing-reversed phase chromatography (IEF-RP), offline strong …
-
Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… to hepatic injury in numerous acute and chronic liver disease states as well as drug-induced liver injury (DILI). The interactions that mediate susceptibility to liver injury and disease, however, are still poorly understood, underscored by the complexity of immune interactions and the diverse …
-
Immune function, gene expression, blood indices and performance in transition dairy cows affected by diet and inflammation
… of NEFA released into blood and available for metabolism in liver (Drackley et al., 2005). The current feeding practices for pregnant non-lactating cows has been called into question because increasing amounts of moderate-to-high energy diets (i.e. those more similar to lactation diets in the …
-
Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… resistance, hypertension, dyslipidemia, and liver steatosis. The incidence of metabolic syndrome and the accompanying risk of developing cardiovascular disease and type II diabetes is dramatically increasing. Disrupted homeostasis of metabolites contributes to metabolic disease. Farnesoid X …
-
Investigating Feeding Omega-3 Polyunsaturated Fatty Acids and/or Soy Protein Isolate to Female pck Rats on Polycystic Kidney Disease and Related Complications
… that include bone loss and polycystic liver disease (PLD). Currently, no genetic therapy or effective pharmacological treatments exist. Therefore, dietary intervention offers a potentially efficacious, cost-effective, and safe therapeutic option for PKD and PKD-related complications. …
-
Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
… little is known about how the clock governs iron metabolism. The regulation of iron within the cell is very tightly controlled, as iron is highly reactive in the generation of oxidative stress and the excretion of excess iron is very limited. There are limited findings indicating that there are …
-
Ethnopharmacology of medicinal plants traditionally used in the Greater Mpigi region, Uganda
… assessment model with simulation of human liver metabolism; and i) a method for transferring research results back to traditional healers in rural indigenous communities. Results: The results of the survey indicated a high level of local traditional use, as the 16 plant species are …
-
Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… hormone that regulates energy balance, metabolism, and the neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral organs, including the …
-
Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… of hepatic gluconeogenic pathways by the Liver X Receptor (LXR), leading to increased expression of hepatic markers associated with gluconeogenesis and increased glucocorticoid signalling. Adult male CIH offspring were also hypercholesterolemic with decreased expression of LXR target genes …
Page 1 of 2