Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"liver iron"”.
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Effects of exercise and protein nutriture on the iron status of rats at selected intervals of gestation
… of two levels of dietary protein and exercise on iron metabolism in pregnant Sprague-Dawley rats was studied. Animals were assigned to the following diet and exercise groups on the first day of gestation: high protein sedentary (HS), high protein exercise (HEx), low protein sedentary (LS), low …
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
Alcohol-associated liver disease (ALD) is a global health issue, with limited treatment options. The pathogenic mechanisms involve many biochemical pathways and processes. Some of the key factors include iron overload, reactive oxygen species (ROS) production and mitochondrial dysregulation. This …
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The effects of zinc intake and exercise on iron status of pregnant Sprague-Dawley rats
… of marginal zinc intake and exercise on the iron status of Sprague-Dawley rats during pregnancy were observed. The dams were assigned to one of four groups: zinc marginal (6.18 ppm zinc sulfate), exercise or sedentary; zinc adequate (37.63 ppm), exercise or sedentary. The dams swam everyday …
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Enhanced Microwave Hyperthermia using Nanoparticles
… used to treat deep tumors in organs, such as the liver. Iron oxide magnetic nanoparticles were considered for this study as they are non-toxic and bio-compatible. For the case of breast cancer, the values for the temperature and specific absorption rate (SAR) in the tumor and in the healthy tissue …
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IRON OVERLOAD AND BIRTH DEFECTS
Large, intravenous doses of iron-dextran are teratogenic in a number of laboratory species (M Phil). To elucidate the mechanism, studies were performed in rats and rabbits to identify possible maternal, placental and foetal sites of action. Maternal toxicity, manifested by bodyweight depression, …
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The effects of exercise on iron metabolism in adult female rats
The effects of exercise training and iron intake on iron metabolism in adult female rats were investigated. Adult female Sprague-Dawley rats were assigned to either an exercise (E) or sedentary (S) group and fed either a diet containing 9 ppm (9) of dietary iron (low iron level), or 40 ppm (40) of …
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The effects of exercise and dietary iron on iron status in 19 month old adult female rats
… investigated the effects of exercise and dietary iron on iron status in 19-month-old female rats. Fifty-seven female Sprague-Dawley rats were randomly assigned to one of five experimental groups: baseline (BL); iron sufficient-exercise (HE); iron sufficient-sedentary (HS); moderate iron deficient- …
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Genetic and environmental modifiers of iron overload disease. Why do only some patients get serious health outcomes?
Type 1 genetic haemochromatosis causes iron overload and is most commonly caused by homozygosity for the HFE C282Y variant and to a far lesser extent other HFE C282Y and H63D genotypes. Haemochromatosis is one of the most common genetic conditions in populations of Northern European ancestry, with …
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Low-dose imaging of liver diseases through neutron stimulated emission computed tomography: Simulations in GEANT4
… between benign and malignant tissue and diagnose liver iron overload while using a neutron beam tomographic acquisition protocol followed by iterative image reconstruction. These studies have shown that moderate concentrations of iron can be detected in the liver with moderate dose levels and long …
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Molecular responses of iron regulatory proteins to iron overload in human liver
Iron is one of the most abundant metals in nature and a necessary element for life. It is not iron per se but rather its implication in the generation of reactive oxygen species that makes the metal harmful when present in excess as seen in iron overload disorders, such as in hereditary …