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Showing 1 to 20 of 81 for “"liver injury"”.
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On Leukocyte Recruitment in Cholestatic Liver Injury
… This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment has emerged as a key feature. Therefore, the aim of this thesis was to analyze the detailed mechanisms behind intrahepatic leukocyte accumulation and …
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The natural history of Efavirenz Drug Induced liver injury
… of the previously reported EFV drug induced liver injury (DILI), is unknown. Objectives To establish causality assessment for the drug-induced liver injury and elucidate the natural history of EFV DILI by observing a cohort of patients through documenting all the factors influencing the …
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Human Liver Organoids as models for investigating drug-induced liver injury
The liver is the primary organ involved in drug detoxification, hence being highly exposed to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… ten years, but the global Nrf2 target genes in liver still remain unknown. The present dissertation utilizes a Nrf2 "gene dose-response" model to genetically modulate the levels of Nrf2 in mouse liver, where the transcription profiles in livers of mice with graded Nrf2 activation were correlated …
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
… are limited therapeutic options for drug-induced liver injury (DILI). N-acetylcysteine (NAC ) is known to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence for the …
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The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
Hepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also investigated. First, the miRNA signature of DILI induced by paracetamol was …
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Liver Injury in HIV-positive Patients on Antituberculosis and/or Antiretroviral Therapy – Assessing Causality
… panel review in identifying a drug-induced liver injury (DILI) due to antituberculosis therapy (ATT) and/or antiretroviral therapy (ART). Methods Cases were drawn from a prospective registry of hospitalised adults with suspected DILI due to ATT and/or ART in Cape Town, South Africa. …
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Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
… TB treatment and or ART-associated drug-induced liver injury (DILI) amongst all patients presenting with significant liver injury to GF Jooste Hospital during the study period. 2. To describe base line clinical characteristics and management of TB treatment and or ART-associated DILI patients. 3. …
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Using free-text searching and ICD-10 codes to identify prospective patients with drug-induced liver injury
<p>Drug-induced liver injury (DILI) is a rare cause of liver disease that is difficult to diagnose due to the lack of a confirmatory test. The Drug-Induced Liver Injury Network (DILIN) was developed to enroll patients with DILI to understand the clinical outcomes of the disease. The present study …
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The Fumonisin B1-Fed Rat as a model for liver injury, oval Progenitor') cell proliferation, and carcinogenesis
… to characterise the FB1-fed rat as a model for liver injury and carcinogenesis, and to examine the role of oval ('progenitor') cells during these processes. Male Fischer 344 rats were fed FB, 250 mg/kg diet for five weeks, and this basic feeding regimen was modified in individual experiments. …
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The fumonisin B₁-fed rat as a model for liver injury, oval ('progenitor') cell proliferation, and carcinogenesis
… to characterise the FB₁-fed rat as a model for liver injury and carcinogenesis, and to examine the role of oval ('progenitor') cells during these processes. Male Fischer 344 rats were fed FB₁ 250 mg/kg diet for five weeks, and this basic feeding regimen was modified in individual experiments. …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
Background: Liver injury is the most common severe adverse effect of first-line anti-tuberculosis therapy (ATT). Nacetylcysteine (NAC) has efficacy in patients with paracetamol toxicity, and may be of benefit in liver injury due to other causes, such as ATT-induced liver injury (AT-DILI). …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
Introduction: The liver is an essential organ in the body responsible for the synthesis of serum proteins, biotransformation, and detoxification of xenobiotic drugs. Drug cytotoxicity studies have been conducted using cancer-derived cell lines which are inferior. In the present study, we developed …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… shown that CYP450 mediates ROS production in the liver of a mouse model of β-thalassemia through an increase in 20-hydroxyeicosatetraenoic acid (20-HETE) activity. Aim: The aim of this study is to assess the efficacy of N-Hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), an inhibitor of …
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Effect of pumpkin seed (cucurbita pepo) protein isolate on the antioxidant enzymes in ccl4-induced liver injury in low-protein fed rats
… against carbon tetrachloride (CCU)-induced acute liver injury in low-protein fed rats were investigated. A group of male Sprague-Dawley rats which were maintained on a low-protein diet for five days were divided into three subgroups. Two subgroups were injected with carbon tetrachloride and the …
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Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD
<p>Non-alcoholic fatty liver disease (NAFLD) represents the major cause of pediatric chronic liver pathology in the United States. The objective of this study was to investigate the effect of partial substitution of dietary lard by an isocaloric amount of olive or coconut oil on endpoints of NAFLD. …
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Manipulating macrophages to enhance liver regeneration
Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic …
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