Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"liver fluke"”.
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Probing the biology of liver fluke-flukicide interplay
Fasciolosis, caused by liver fluke parasites of genus Fasciola, is responsible for reducing global agricultural yield in livestock animals and is a neglected tropical disease of humans. A limited portfolio of flukicide drugs are available, however treatment of the highly pathogenic acute stage is …
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Liver fluke development: a target for parasite control?
… of FPCs, their facilitative roles within fluke growth and indicate their importance to fundamental fluke biology. The disruption and dysregulation of this cell population may hold the key to developing novel control therapies.
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Using post-genomics technologies to advance understanding of liver fluke therapeutics
… active against immature and mature stages of the liver fluke. Widespread reports of drug resistance coupled with increasing infection forecasts (due to climate change and the intensification of farming), highlight the requirement for a better understanding of drug resistance mechanisms and for …
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DISEASE IMPACTS ON MOOSE (ALCES ALCES) HEALTH AND ECOLOGY ALONG THEIR SOUTHERN RANGE LIMITS: PARASITES AS A LIMITING FACTOR IN NEW YORK
… worm (Parelaphostrongylus tenuis) and giant liver fluke (Fascioloides magna), incidentally infect and sometimes kill moose, resulting from spatial overlap with the parasites’ definitive host, white-tailed deer (Odocoileus virginianus). To determine whether parasites function as a limiting …
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Characterisation of the Fasciola hepatica miRNome and an evaluation of its role in the host-parasite relationship
The liver fluke, Fasciola hepatica, is recognised as one of the most successful parasites worldwide due to its remarkable capacity to infect every mammal it encounters. For this reason, liver fluke disease, or fasciolosis, has the widest geographical spread of any parasite disease and contributes …
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Post-genomic studies on the neuropeptide signalling system of Juvenile <i>Fasciola hepatica</i>
… of the neuropeptide signalling pathway in liver fluke and provides a foundation for more focussed studies on drug target discovery and validation.
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The synthesis, structural characterization and biological evaluation of potential chemotherapeutic agents
… significantly greater inhibitory potency on the liver fluke Fasciola hepatica cysteine cathepsin L like endoproteases over the known commercial inhibitor Z-Phe-Ala-CHN₂ at varying concentrations. The synthesis, structural characterisation and biological evaluation of a series of analogues of this …
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Linking environmental variation across the Scottish Highlands with red deer (Cervus elaphus) trace element status, parasite burden, and skeletal morphometry
… egg count (FEC) method for quantification of liver fluke (Fasciola hepatica) prevalence in Scottish Highland red deer.<br/>2. Reveal substantial geographic variation in the prevalence of F. hepatica in wild red deer in the Scottish Highlands, and that an individual’s probability of infection: …
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Sensing at nanostructures for agri-food and enviromental applications
… made sustainable. Globally, agriculture must deliver a 60% increase in food production to cope with the population demand. Moreover, this needs to be achieved against a changing climate, an exploitation of natural resources, and growing water and land scarcities. New digital technologies can …
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Modulation of macrophage function and immune response by a helminth-derived cysteine protease
… 2012). In our laboratory, the ES products of the liver fluke trematode, Fasciola hepatica, have been shown to prevent autoimmune type 1 diabetes in a murine model (Lund et al. in preparation). Disease prevention was associated with the initiation and perpetuation of anti-inflammatory/regulatory …
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Comparison of host-parasite relationships of Fasciola gigantica infection in cattle (Bos indicus) and swamp buffaloes (Bubalus bubalis)
… was significantly higher in buffaloes with high fluke burdens (>70 flukes) than those with no flukes or with medium fluke burden (21-70 flukes) (P<0.05). Significantly higher PCV value was also observed in buffaloes with high fluke burdens compared with those with low or medium worm loads …
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Use of molecular markers to investigate epidemiology of and host manipulation by the invasive parasite Dicrocoelium dendriticum
Parasite distributions are rapidly expanding, in large part due to human mediated translocations of hosts. Thus, instances of parasite-spread to new hosts are common. Management of these emerging parasites depends on understanding the host-shifts occurring within invasive areas and the pathway of …