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Showing 1 to 20 of 57 for “"liver fibrosis"”.
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LIVER FIBROSIS IMPAIRS HEPATOCYTE TRANSDUCTION BY AAV VECTORS
… vectors (AAVs) are the most promising tools for liver directed gene therapy. However, integrity of hepatic architecture has been considered pre-requisite for efficient gene delivery and clinical studies have been addressed toward patients with no or negligible hepatic damage and fibrosis. …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
<p>Liver fibrosis is characterized by progressive activation of proliferating and migrating myofibroblasts that lead to accumulation of extracellular matrix (ECM). These myofibroblasts most arise from activated liver-resident hepatic stellate cells (HSCs). There is an increasing number of patients …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) leads to the reversal of the accumulated extracellular matrix. We therefore hypothesize that targeted …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial growth factor (VEGF) and IκB kinase ε (IKBKE) were used for treating TNBC, while siRNA targeting …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… dissertation is to develop peptide-based siRNA delivery systems for the treatment of liver fibrosis and pancreatic ductal adenocarcinoma (PDAC). We recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) and NIH 3T3 fibroblasts can reverse …
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Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis
… of ECM is the common characteristic of liver fibrosis. During hepatic fibrosis, various inflammatory cytokines are released and trigger the activation of quiescent HSCs. The activated HSCs play the major role in producing extra amount collagen. It becomes very crucial to focus on HSCs to …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
Hepatic fibrosis is a cellular repair mechanism that is initiated upon prolonged damage to the liver, resulting in an accumulation of excess extracellular matrix. This eventually leads to the formation of scar tissue, which disrupts the hepatic architecture and causes liver dysfunction. Hepatic …
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Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis
The liver is responsible for lipid and glucose metabolism, protein and bile synthesis and the biotransformation of xenobiotics. These functions, performed by hepatocytes, are dependent on heterotypic interactions with other liver cell types and the stratified microarchitecture of the organ. In …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and pro-nerve growth factor/p75 neurotrophin receptor-mediated signals. Whilst mature nerve growth factor is proapoptotic, pronerve growth factor …
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Evaluation of serum prolidase activity as a marker for liver fibrosis in suspected liver disease
Liver dysfunction is common, often unrecognised and likely to increase in incidence in the population in parallel with the obesity and attendant type 2 diabetes mellitus epidemics. Liver fibrosis is a significant finding in liver pathology as it imparts important clinical staging and prognostic …
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Liver Fibrosis and Steatosis in HIV-Infected Patients: Impact of Race/Ethnicity, Gender, BMI, and ART
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
Liver cirrhosis is a leading cause of death worldwide, with the prevalence of cirrhosis on the rise. Cirrhosis is driven by various etiologies, including liver injuries from diabetes, obesity, metabolic disorders, and alcohol use. Central to the progression of chronic liver disease to cirrhosis is …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
Metabolic Associated Steatotic Liver Disease (MASLD) is the most prevalent cause of chronic liver disease worldwide and a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC). Despite its pathogenesis being determined by both environmental and genetic determinants, the genetic …
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Deconstructing the influences of combinatorial microenvironmental cues on human non-parenchymal liver cells in models of liver fibrosis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation
… the outcome of islet transplantation.</p> <p>Liver fibrosis is a consequence of chronic liver disorders which lead to accumulation of extra cellular matrix (ECM). Particularly, there is an increased accumulation of collagen in the fibrotic liver. We have therefore used a triplex forming …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of …
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