Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"liver enzymes"”.
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Investigations into the Effects of Turmeric, Cinnamon and Green Tea on Glycaemic Control and Liver Enzymes
… No significant changes were seen in lipids or liver enzymes.
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Temperature acclimation in the channel catfish, Ictalurus punctatus: Seasonal variation and cellular mechanisms
Seasonal variations were seen in liver composition and activities of liver enzymes of channel catfish acclimated to $7\sp\circ\rm C,$ $15\sp\circ\rm C,$ or $25\sp\circ\rm C.$ Fall and winter catfish exhibited positive acclimation for total liver protein and DNA, hepatosomatic index, and activity of …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
… years of use and to explore CYP450 activity and liver function as potential mechanism for extended-release eprinomectin to mitigate fescue toxicity in fall-born beef heifers grazing endophyte-infected tall fescue. Only one extended-release anthelmintic is currently on the market for ruminants and …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… during fibrogenesis are scarce. Methods: Here, liver fibrosis was assessed subsequent to bile duct ligation by determining liver enzymes in serum and collagen deposition in liver tissue. Activated hepatic stellate cells were identified by immunohistochemistry and immunoblots for alpha smooth …
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Nonalcoholic steatohepatitis (NASH) : animal studies of interactive hepatoxicity
… steatohepatitis" (NASH) describes a form of liver disease indistinguishable from alcoholic liver disease, but present in persons who consume insignificant amounts of alcohol. The spectrum of non-alcoholic liver disease ranges from non-progressive steatosis, through to NASH and sometimes to …
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General anaesthesia for caesarean delivery for thrombocytopaenia: findings from an obstetric airway management registry
… with thrombocytopenia, 2 had hemolysis elevated liver enzymes and low platelets (HELLP) syndrome, 2 had antepartum hemorrhage with preeclampsia, and 1 had isolated thrombocytopenia with preeclampsia. Conclusions In 17% of patients the indication for GA was thrombocytopenia. Many patients received …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
… derived compounds metabolized by phase I and II liver enzymes. Phase I enzymes increase, and phase II enzymes decrease, xenobiotic toxicity. Xenobiotics considered were ergotamine, associated with fescue toxicosis, and sulforaphane, a phase II inducer. Hypothesized responses in liver gene …
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
… of HCV patients before and after DAA treatment. Liver biopsies were analyzed using NanoString nCounter and multispectral imaging to determine gene expression and immune cells phenotypes. Then, the findings were correlated and analyzed with clinical outcomes. Patients achieved sustained virologic …
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USE OF HEIGHT AND GENDER BASED WAIST CIRCUMFERENCE CHARTS IN PEDIATRIC OBESITY MANAGEMENT
… cholesterol, total cholesterol, glucose, and liver enzymes were calculated for participants ages 12 and older. The 2001-04 sample was used to develop cut points for the waist circumference percentiles by evaluating sensitivity and specificity. A reclassification system was designed that adds …
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Prognostische Bedeutung und ätiologische Aspekte von Leberfunktionsstörungen bei internistischen Intensivpatienten
… retrospective study deals with the importance of liver dysfunction regarding internal critical care patients. The following aims were persuited by the study: 1. Evaluation of the prognostic importance of the hepatic function. 2. To attain an overview of hepatic function development and the …
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Evaluation of lysine and metabolizable energy in diets for broilers
… body composition, blood parameters and liver enzyme activity of broilers from 1 to 14 days of age. A total of 768 male broilers were allocated in a completely randomized design in a 3×4 factorial scheme, with 8 replicates. The levels varied in ME (2950, 3050 and 3150 kcal/kg) and …
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An investigation into the potential mutagenicity of South African traditional medicinal plants
… were selected for the investigation. The rat liver extract (S9), containing CYP P450 and other liver enzymes, was added to the in vitro cell system to detect pro-mutagens that require metabolic activation in order to exert mutagenicity or clastogenicity - directly acting mutagens do not …
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The impact of different dietary patterns on nutritional status and metabolic integrity in asymptomatic people living with HIV infection in South Africa
… serum albumin (1.5, 0.9-2.4) and lower liver enzymes AST (0.5, 0.3-0.8) and ALT (0.6, 0.4-0.9). Using Graphical Chain Modelling, higher intake of the animal-based but lower staple-based dietary patterns were associated with better overall nutrient intake, serum vitamins A, E, lipid …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
Metabolic Associated Steatotic Liver Disease (MASLD) is the most prevalent cause of chronic liver disease worldwide and a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC). Despite its pathogenesis being determined by both environmental and genetic determinants, the genetic …
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Studies on pro-oxidant cytochrome P450 enzymes as drug discovery tools and the discovery that they also have a dual function as antioxidants
… in mind. (i) CYP1A1, CYP1A2, and CYP1B1 are enzymes highly up-regulated in lung cancers that are caused by inhaling or coming into contact with polyaromatic hydrocarbons (PAHs) which exist in cigarette smoke, in the close proximity to petrochemical industries and in environments which are …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… reaction (3), mild skin reaction (14), elevated liver enzymes (2), and worsening interstitial lung disease ILD (1). bDMARD Therapy was discontinued in 18 patients, most commonly due to adverse reaction (9), lack of response (3), poor adherence (2), or remission (1). bDMARD Therapy was changed to …
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Pentobarbital Sleep Time in Mouse Lines Selected for Resistance and Susceptibility to Fescue Toxicosis
… R mice had higher activities of Phase II liver enzymes glutathione S-transferase and uridine diphosphate glucuronosyl-transferase than S mice. Objectives of this study were: 1. to determine whether selection for toxicosis response had also caused divergence between lines in hepatic Phase I …
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An in vitro and in vivo hepatotoxicity study of an aspalathin- rich green rooibos extract
Hepatotoxicity is an undesirable condition of the liver, often occurring due to the interaction of drugs. Although different methods have been employed in the diagnosis of drug-induced hepatotoxicity, none have accurately proven the hepatotoxic effect of drug-drug interactions or drug-herb …
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Advantages of MesoRex shunt compared with distal splenorenal shunt for extrahepatic portal vein occlusion in children
… (PH) is a common complication of chronic liver or portal vein pathology in children. It is defined as a pathological increase in the pressure of the portal venous system. There are two leading causes for PH in children, pre and post sinusoidal liver disease and pre-hepatic non-cirrhotic …
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… of specific relevance is non-alcoholic fatty liver disease (NAFLD) and its advanced disease state known as non-alcoholic steatohepatitis (NASH), as it has had a documented rise in prevalence parallel to that observed with obesity. Currently there are no FDA approved therapeutics for NAFLD or …
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