Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 278 for “"liver disease"”.
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Clinical guidance for polycystic liver disease
Contains fulltext : 299164.pdf (Publisher’s version ) (Open Access)
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
Alcohol-associated liver disease (ALD) is a global health issue, with limited treatment options. The pathogenic mechanisms involve many biochemical pathways and processes. Some of the key factors include iron overload, reactive oxygen species (ROS) production and mitochondrial dysregulation. This …
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic and dangerous condition which has grown in prevalence over recent decades due to increasing rates of obesity, affecting roughly a quarter of adults globally. This thesis develops a useable NAFLD definition which can be applied to large …
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The role of MBOAT7 on fatty liver disease
https://gupea.ub.gu.se/handle/2077/67133
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The molecular genetic investigation of paediatric liver disease
Liver disease in children is rare but often serious, life long, and in many cases leads to death. Advances in diagnosing and treating liver disease (including liver transplant) have improved the outlook for children in many cases however little is known about the molecular pathogenesis of the …
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Molecular pathogenesis of Helicobacter hepaticus induced liver disease
… hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions in H. hepaticus infected and control male A/JCr mice at 3 months, 6 months, and 1 year of …
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Platelet Function in Dogs with Chronic Liver Disease
Background: Dogs with acquired chronic liver disease often have hemostatic derangements. It is currently unknown whether dogs with acquired chronic liver disease have decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist due to the obesity epidemic and its potential to progress to an advanced liver disease that significantly impacts on overall and liver-related mortality. Due to the rapidly …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
Non-alcoholic fatty liver disease (NAFLD), recently renamed as Metabolic dysfunction-associated steatotic liver disease (MASLD), is the leading cause of chronic liver disease (CLD) and liver-related morbidity and mortality worldwide. NAFLD, characterized by hepatic fat accumulation and coexisting …
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Factors associated with Liver Stiffness in Chronic Liver Disease
"목적: Tansient elastography는 간탄성률을 측정하여 간섬유화 및 간경변증을 예측하는 것으로, 비교적 정확하고, 비침습적인 방법이다. 그러나 최근 발표된 많은 연구에서 간탄성률은 만성바이러스간염환자에서 aminotransferase의 변화에 따라 영향을 받는 것으로 보고 되었다. 본 논문은 만성 간질환 환자를 대상으로 간탄성률 측정에 영향을 미치는 요인을 알기 위해 연구를 시행하였다 방법: 2005년 9월부터 2008년 9월까지 Tansient elastography와 간조직 검사를 시행한 만성 간질환 환자 …
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Machine learning and data analytics for liver disease modeling
… (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
It has been proposed that liver regeneration in chronic liver disease, such as metabolic dysfunction-associated steatotic liver disease, previously known as non-alcoholic fatty liver disease, is driven by hepatocyte renewal in the early stages, but when hepatocyte proliferation is impaired due to …
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Predicting Progression of Metabolic Dysfunction-associated Steatotic Liver Disease
… from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis, a more serious prognosis that can lead to liver failure and death. Additional adverse progressed outcomes include hepatic failure, fibrosis, cirrhosis, and malignant neoplasm of liver and …
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Multidimensional Experience of Pain in Adults with Advanced Liver Disease
… problem for adult patients living with advanced liver disease such as cirrhosis. Poorly managed pain can reduce the quality of living and dying among this growing population. The lack of research exploring the physical, psychological, and sociocultural dimensions of pain may contribute to …
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Engineering in vitro models of non-alcoholic fatty liver disease
… the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population currently diagnosed. NAFLD starts as a benign state of fat accumulation within liver hepatocytes but often …
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Fuzzy Decision Tree-based Inference System for Liver Disease Diagnosis
… the application of fuzzy logic to help diagnose liver diseases based on blood test results. In this project, inference systems aimed at classifying patient data using a fuzzy decision tree and a fuzzy rule-based system were designed and implemented. Fuzzy decision tree was used to generate rules …
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The Orotic Aciduria of Chemical Hepatotoxicity (Liver Disease, Alcohol, Galactosamine)
… orotic aciduria in rats: chemical damage to the liver by (1) carbon tetrachloride, (2) ethanol, (3) galactosamine, (4) partial removal of the liver, and (5) meal feeding by growing animals. Orotic acid excretion also depends upon: the dietary lysine/arginine ratio, and blood ammonia …
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