Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"liver damage"”.
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Noninvasive Monitoring of CCl4 Induced Acute and Chronic Liver Damage in Rat by Single Quantum and Triple Quantum Filtered 23Na Magnetic Resonance Imaging
… progression of CCl4 induced acute and chronic liver damage in rat model. SQ 23Na MRI was proposed to measure the 23Na signal intensity (SI) of total tissue sodium ions, and TQF 23Na MRI was proposed to measure the SI of intracellular sodium ions. In addition, shift reagent aided 23Na and 31P …
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Biomarkers in the measurement of hepatic damage in sheep
The measurement of urinary taurine and the liver specific enzymes AST and GGT in sheep with hepatic damage was undertaken to determine if urinary taurine could be used as a biomarker of hepatic damage. Two treatment groups (n = 5) were treated with O.125ml/Kg BW of carbon tetrachloride (CCl₄) …
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Role of Src phosphorylation of FXR in bile acid regulation
… molecules. Elevated bile acid levels in the liver can lead to cholestatic injury, primary biliary cirrhosis, fibrosis, and liver cancer; therefore, these levels must be tightly regulated. The farnesoid X receptor (FXR) is the primary bile acid nuclear receptor and acts as the master regulator …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
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Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy
… drug efficacy and the overall health of the liver. A mathematical model was introduced in 2009 to help elucidate the host-virus dynamics after the start of therapy. The model allows the study of complicated viral patterns observed in HBV patients. In our research, we will analyze this model …
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Metabolic Reprogramming in Response to Mitochondrial Electron Transport Chain Dysfunction
… acceptor, a-ketobutyrate. Furthermore, in the liver, loss of ETC complex I results in no observable clinical or biochemical phenotype, while complex IV deficiency results in steatosis, liver damage, and significant biochemical alterations. The studies herein demonstrate metabolic reprogramming …
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Role of the IKK complex during liver regeneration
The transcription factor NF-kB is essential for liver homeostasis. The IKK complex (composed by two catalytic subunits IKK1 and IKK2 and a regulatory subunit Nemo) tightly regulates NF-kB activity. In the present work, we modulated NF-kB activity in the liver by using hepatocyte-specific IKK2 …
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The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
… association study of thiopurine-induced liver damage (TILI). Ultimately, the study was underpowered to detect any associations of moderate effect size and did not detect any associations of high effect size amongst the common genetic variants. Interestingly, I was not able to replicate …
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The Examination of the Link Between Pesticides in Food and Learnig Disorders in Children
… toxic chemicals are more susceptible to cellular damage such as nerve damage, cancers, and liver damage than adults.</p>
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Pengaruh pemberian Lumbricus rubellus terhadap gambaran histologis hepar dan aktivitas antioksidan dalam serum darah pada Rattus norvegicus yang terinfeksi Salmonella typhi
… by BNJ test 1%. The results indicate that liver damage Fhitung> Ftabel = 7.13> 6.36, whereas the antioxidant activity also showed Fhitung> Ftabel = 104.96> 6.36 which means that there is a marked influence of concentration and duration of administration to the improvement of flour worms …
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An analysis of the relationship between alcohol availability and alcohol-related hospital admissions in the city of Chicago, 1990--1997
… admissions, such as acute intoxication and liver damage, has not been widely explored. Measuring alcohol availability by alcohol outlet density and using data for alcohol related hospital admissions in the city of Chicago, a Poisson regression analysis determined that neighborhoods with a …
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Thrombozytenantikörper bei Hepatitis-C-Infektion für die Diagnose einer Autoimmunthrombozytopenie
… As control group 35 patients with an alcoholic liver damage were examined. The results were compared with other laboratory results and medical findings in these patients. Summarized you can say, that irrespective of the frequent development of thrombocytopenia and platelet autoantibodies in …
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Assessment of Largemouth Bass (Micropterus Salmoides) Condition Using Liver Histopathology, Health Parameters and Water Quality Of The Central Chattahoochee River Watershed
… from west-central Georgia was assessed using liver histopathology and the degree of tissue change index (DTC), hepatosomatic indices (HSI), relative weight, condition factors, and intersex. These health parameters as well as water chemistry data were compared across four bodies of water, three …
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The effects of left hepatic vein ligation on hepatic circulation, function and microanatomy
… vein ligation does not cause severe or permanent liver damage. These findings support a clinical trial of this procedure in patients with patent ductus venosus.
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The anti-estrogenic and liver metabolic effects of DHAA in rainbow trout (oncorhynchus mykiss)
… in order to assess the endocrine disrupting and liver metabolic effects of the wood extractives DHAA and β- sitosterol (BS) regularly present in pulp and paper mills and the model estrogen 17β-estradiol (E2). It was found that exposure to 5 ppm of E2 significantly increased hepatosomatic index …
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Designing bifunctional materials for in-situ capture and conversion of volatile organic compounds
… catastrophic health effects such as cancer or liver damage even at very low concentrations (ppm), and the control of these compounds is vital in ensuring good air quality. </p><p>Many VOCs are used in common household implements such as wood finishes or paints and can even be emitted off …
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Šiuolaikinis uždegiminių žarnų ligų gydymas. Indikacijos, kontraindikacijos biologinei terapijai, jos sukeliamos komplikacijos /
… disorders; dermatological disorders; liver damage; immunogenicity against biologics. Knowledge of the new biologic drugs (ustekinumab, vedolizumab) is limited, so it is recommended that more attention be paid to their research.
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Elucidating the role of SRSF1, a prototypical splicing factor, in liver physiology
… prototypical splicing factor, in the context of liver physiology. I began by generating and characterizing hepatocyte-specific SRSF1 knock-out mice models. These mice developed severe liver damage and exhibited pathology like the human disease Non-alcoholic steatohepatitis. Specifically, loss of …
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