Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"liver colonization"”.
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… arrival at the end organ and finally colonization of the end organ. The liver is the primary site of colon cancer metastatic colonization, with over 70% of colon cancer patients experiencing liver metastases. Despite current standard-of-care surgical intervention and broad spectra …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… survival, dissemination and metastatic liver colonization by colon cancer cells. Finally, pharmacological treatment of mice with a PANX1 inhibitor suppresses breast cancer metastasis to the lungs, implicating PANX1 as a therapeutic target in cancer. These findings reveal that mutational …
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Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
… process remain poorly understood. Metastatic colonization is the final step of the metastatic cascade whereby cancer cells form a tumor at a distant site. This final step is the culmination of clonal evolution of cancer populations that results in a highly aggressive population with enhanced …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
… cancers initially metastasize to the liver first. While the prognosis of early-stage cancers is improving, a significant proportion of patients have metastatic disease at the time of diagnosis leading to poor survival outcomes. I focused on colorectal cancer and pancreatic cancer, the …