Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"liver carcinogenesis"”.
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A new mouse model to probe the role of aflatoxin B₁ in liver carcinogenesis
… that 6mg/kg at this age results in near 100% liver tumorigenesis, this timecourse provides significant intuition for the onset and persistence of DNA damage. The results showed that AFB₁-N7-Guanine adduct formation maximized at two hours post dosing and then decreased rapidly; its FAPY …
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The Effects of Time-Restricted Feeding on Early Phases of Liver and Colon Carcinogenesis
The influence of dietary factors on carcinogenesis, particularly the role of high-fat diets, is well-documented, with such diets contributing to altered lipid metabolism, the development of metabolic stress, and chronic inflammation. Given the growing interest in time-restricted feeding (TRF) as a …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… HCC, the related non-tumor tissue, and normal liver tissue. Relative quantification of miR-122 and miR-191 in 16 HCV-associated HCC, 10 HBV-associated HCC, the respective neighboring non-tumor tissue, and 9 normal liver tissue samples was performed using RT-PCR. This thesis shows that miR-122 …
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
Rates of primary liver cancer are increasing in the Western world, a fact yet to be reflected in research with most currently undertaken in Asia. Whilst here in the UK, during a diagnostic and therapeutic workup within the NHS, surgically resected tumours are routinely kept in storage for up to …
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
… Our microarray analysis, performed in the liver of rats subjected to the Resistant Hepatocyte (R-H) model, revealed that Hao2 was among the most down-regulated genes in HCCs developed, 14 months after initiation with a single dose of the hepatocarcinogen Diethylnitrosamine (DENA). Next, we …
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Insights into transcriptional regulation from natural and induced variation in closely related species
… on as a member of a collaborative effort of the Liver Cancer Evolution (LCE) consortium. The project makes use of a model of chemically induced liver carcinogenesis in different mouse species, which offer a controlled biological system with natural genomic and epigenomic variation. Here, I …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… I present a project I worked on as part of the Liver Cancer Evolution (LCE) consortium. To gain insight into the influence of the genetic background on mutagenesis and cancer susceptibility, the LCE consortium used a model of chemically induced liver carcinogenesis across four mouse species. …
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Analisi integrata dell'espressione di geni/microrna in un modello di epatocancerogenesi sperimentale
… value of the R-H model in recapitulating human liver cancer. Conclusions: This systematic analysis deciphered the molecular phenotypes of the several steps involved in the onset and progression of HCC and investigated their variations at mRNA and miR levels. In view of the striking similarity …