Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"liver X receptor"”.
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… upregulated metabolic dependence of cancer. The liver X receptors (LXR) are ligand-modulated nuclear receptors. LXR activation upregulates the expression of genes involved in altered metabolic pathways in cancer, including cholesterol transport, glucose, and lipid metabolism. Moreover, LXR …
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Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus
… autoantibodies. The human interleukin 6 receptor (IL6R) consists of 2 membrane-bound glycoproteins interacting with IL6, which is a multifunctional cytokine essential to the regulation of the immune response and acute-phase reaction. Liver X receptor alpha (LXRA, NR1H3) and beta (LXRB, …
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The Roles of ATP-Binding Cassette Transporters G5 and G8 in Liver X Receptor-Mediated Sterol Trafficking
The liver X receptor (LXR) is a nuclear receptor that plays a critical role in orchestrating the trafficking of sterols between tissues. Treatment of wild type mice with a potent and specific nonsteroidal LXR agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased …
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Evaluating the Mechanisms of 2-Hydroxypropyl-β-Cyclodextrin and Liver X Receptor Agonists as Potential Therapies for Niemann-Pick Type C Disease
Cholesterol is essential to life; therefore, the synthesis, entry, and efflux of cholesterol are tightly regulated. In some rare disease states, such as in Niemann-Pick Type C, cholesterol balance is lost leading to detrimental effects. In Niemann-Pick Type C, mutations in either of the cholesterol …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… release. Oxysterols are known as nuclear receptor liver X receptor agonists, and these inhibitory effects were observed with synthetic agonists of liver X receptor and retinoid X receptor in a similar manner. In addition, ATP-binding cassette transporter a1 transcription, LXR-induced …
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Porcine model of xenobiotic metabolism
… introduced into the body. Orphan nuclear receptors play crucial role in regulation of the expression of DMEs. The pig has quickly grown into an important biomedical research tool over the past few decades. The pig is an appropriate animal model for the investigation of xenobiotic …
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Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… of hepatic gluconeogenic pathways by the Liver X Receptor (LXR), leading to increased expression of hepatic markers associated with gluconeogenesis and increased glucocorticoid signalling. Adult male CIH offspring were also hypercholesterolemic with decreased expression of LXR target genes …
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Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
… to decreased binding of the nuclear repressor coreceptor 1/2 (NCOR1/2) complex in the promoters of its target genes in the absence of MECP2, leading to their upregulation. I also showed that lung AE2 cell-specific depletion of Mecp2 is sufficient to cause lung lipid metabolism abnormalities and …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… of low-density lipoprotein (LDL). Toll-like receptors (TLRs) play a central role for macrophages to detect pathogens and elicit inflammatory responses.</p> <p>Data presented in this study have furthered our understanding of the different mechanisms of foam cell formation induced by <em>C. …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… of a class of proteins called nuclear hormone receptors, which respond to lipophilic compounds to regulate gene transcription. I have undertaken three separate, but related projects relating to lipid metabolism with a particular focus on nuclear hormone receptor function. First, I sought to …
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Studies on cholesterol metabolism in prostate cancer cells
… which increases cholesterol levels, and (2) liver X receptor (LXR), which reduces cholesterol levels. From this, we found that cholesterol accumulation was stimulated by signals that promote PCa cell-growth for example, male sex hormones act via the androgen receptor (AR) to enhance SREBP-2 …
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Modeling and Validation of Gene Networks in Breast and Pancreatic Cancer
… role in mediating the cytotoxic effects of liver x receptor (LXR) β activation in pancreatic cancers. This study revealed that LXRβ activity up-regulated the genes involved in pro-apoptotic fatty acid production and endoplasmic reticulum stress genes and down-regulated cell cycle genes. Many …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… the acute phase response signaling system and liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) activation. Conclusion: Plasma proteomic profiles are altered in cancer cachexia and disuse-induced atrophy. Modulated protein profiles suggest the …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… (LPS) –induced signaling pathways 8 3. Liver X receptor (LXR) pathway as anti-inflammatory signaling Pathway 9 D. Aims of study 10 II. MATERIALS AND METHODS 11 A. Reagents 11 B. Cell culture 12 C. Electrophoresis mobility shift assay (EMSA) 12 D. Reverse transcriptase-polymerase chain …
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Identification of molecular targets regulating fatty acid synthesis in bovine mammary epithelial cells
… element binding protein-1 (SREBP1) and liver X receptor (LXR). In vivo, diet-induced milk fat depression or supplementing diets with polyunsaturated fatty acids inhibits milk fat synthesis by regulating SREBP1 expression. Results confirm that polyunsaturated fatty acids inhibit fatty …
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Regulatory factors of milk fat synthesis in dairy cows
… for SREBP-1, peroxisome proliferator-activated receptor γ (PPARγ), or liver X receptor (LXR). The activation of PPARγ and SREBP-1 were stimulated by insulin and insulin combined with leptin, respectively. Trans-10, cis-12 conjugated linoleic acid (CLA) inhibited SREBP-1 activation, and this …
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Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
… for metastatic relapse. Notably, therapeutic delivery of specific locked nucleic acids (LNAs) antisense to the three miRNAs synergistically suppressed metastasis in pre-clinical models, attesting to the therapeutic potential of combinatorial miRNA silencing for the prevention of melanoma …
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An interdisciplinary approach leveraging human genetic variation to identify novel mechanisms of liver disease and pregnancy sickness
… of rare variants in the cholesterol sensing receptor LXRand undertook a functionally enriched human genetic association study. Using this approach, I demonstrated that loss of function mutations in LXR(Liver-X-Receptor-alpha) are a cause of hepatotoxicity in humans despite evidence of …