Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"live-vaccine"”.
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Investigations Into a Rationally Designed Modified Live Vaccine for Equine Strangles
… disease is the lack of a safe and efficacious vaccine. The production of a safe and efficacious vaccine has been difficult. Currently available modified live vaccines lack safety and, to date, subunit vaccines have been ineffective in preventing experimental challenge. The goal of this work is …
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Development of plant-produced African horse sickness vaccines
… broadens with global warming and climate change. Live attenuated vaccines (LAV) have been used with relative success for many decades, but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the …
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Identification and characterization of a novel capsule-like complex surface antigen of Francisella tularensis
… (TEM). I found that the CLC in the type B live vaccine strain (LVS) could be significantly diminished by deleting two glycosyl transferase genes (LVSΔ1423-22) in the putative polysaccharide locus, FTL_1432-FTL_1421. In addition, I determined that the CLC was not a typical polysaccharide …
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Assessment of the Expression of Brucella Abortus Heat Shock Protein, Groel, in Vaccinia Virus to Induce Protection Against a Brucella Challenge in Balb/C Mice
… in cattle and undulant fever in humans. Cattle vaccines such as B. abortus strains 19 and RB51 are live vaccine strains which protect approximately 75% of the vaccinated animals. No effective vaccines are available for the prevention of brucellosis in humans. We are developing vaccinia virus …
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NOVEL STRATEGIES TO DEVELOP BETTER BRUCELLOSIS VACCINES USING BRUCELLA ABORTUS RB51 AND B. NEOTOMAE
… attenuated mutant which is used as a licensed live vaccine for bovine brucellosis in the United States and several other countries. Previous studies have shown that the wboA gene, which encodes a glycosyltransferase required for the synthesis of O-polysaccharide in Brucella, is disrupted in B. …
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Studies on development of a Leishmanial vaccine
… deaths per year.;Therefore, development of a vaccine to prevent infection is required. The overall aim of this study was to develop a vaccine to protect against Leishmania infection using live nonpathogenic L. tarentolae transfected with gamma glutamylcysteine synthetase (γGCS) from three …
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Genetic Stability of a Genetically-Engineered Chimeric Porcine Circovirus (PCV) Vaccine, PCV1-2
… type 2 (PCV2) is pathogenic. A recently released vaccine for PCVAD was generated by inserting the gene encoding the immunogenic capsid protein of PCV2 into the genetic backbone of the non-pathogenic PCV1. This chimeric PCV vaccine, called PCV1-2, was shown to induce protective immunity against …
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Lactobacillus strategies to reduce Campylobacter jejuni colonization of broiler chickens
… The probiotic Lactobacillus spp. are a viable delivery vehicle for mucosal vaccines due to the Generally Recognized As Safe (GRAS) status. In addition, recombinant lactobacilli present proteins to the mucosal surface and elicit host immune responses. The overall objectives of this research were …
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Immunological control of toxoplasma gondii infection
… and encephalitis. Currently there are no human vaccines available. The first major aim of this study was to test potential HLA restricted peptide vaccines, previously shown to be protective in HLA-transgenic mice, against oocyst infection. The ability of entrapment within non-ionic surfactant …
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Generierung von Transposonmutanten des Epstein-Barr-Virus zur Charakterisierung von Genfunktionen für die lytische Virusvermehrung und die virale Latenz
… latency. This makes them candidates for an EBV live vaccine.
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Genomic Instability and Gene Dosage Obscures Clues to Virulence Mechanisms of F. tularensis species
… dose of TI0902 and was considered as a possible vaccine strain. Whole genome sequencing was performed to identify genetic differences between the virulent, avirulent and protective strains using both Roche/454 and Illumina next-generation sequencing technologies. Additionally, RNASeq analysis was …
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Unraveling the host innate immune response to a respiratory model of Brucella abortus
… bacteria that cause abortion and infertility in livestock and chronic disease in humans. The Centers for Disease Control and Prevention (CDC) categorizes them as class B pathogens due to their zoonotic potential. Currently, there are no efficacious Brucella vaccines for humans available. Very few …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
… to the Poxviridae family that was used as the live vaccine leading to the eradication of smallpox. Despite eradication through global vaccination, the precise immune mechanisms underlying recovery from infection are incompletely understood. VACV is commonly studied after infection of the lung …
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The roles of papain-like protease-related proteins in viral replication and host immunity
… PRRSV pathogenesis and development efficient vaccines are highly required in swine industry. PRRSV nsp2-related proteins including nsp2 and two ribosomal frameshifting products-nsp2TF and nsp2N share the same N-terminal PLP2 domain. In chapter 2, nsp2TF and nsp2N were demonstrated to be …
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Site-Directed Mutagenesis in Francisella Tularensis by Allelic
… severity of illness, and lack of licensed vaccines, F. tularensis has long been considered a potential biological weapon and is now classified as a category A select agent by the National Institutes of Health and the Centers for Disease Control and Prevention. The investigation of the …
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The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5A: role in serum resistance and characterization of the genetic basis for expression
… mutant will be evaluated as a potential live vaccine strain for the control of swine pleuropneumonia.
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Konstruktion und Charakterisierung von Lebendvakzine-Kandidaten auf der Basis von siaD-Deletionsmutanten von Neisseria meningitidis Serogruppe B
In der vorliegenden Dissertation wurde für die Entwicklung eines Lebendimpfstoffs zum Schutz vor Infektionen durch Neisseria meningitidis Serogruppe B zunächst ein geeigneter Impfstamm aus mehreren Neisserienstämmen der Serogruppe B, ST-32 Komplex, ausgewählt. In diesem sollte anschließend die …
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Molecular, biochemical and functional analysis of kinesins in Leishmania mexicana
… out these mutant parasites as an attenuated live vaccine. LmxOSM3.1 and LmxOSM3.2 were found to be homologous to flagellar kinesin-2 in trypanosomatids (L. major and T. brucei). They also showed sequence similarity with kinesin-2s of human kinesin KIF3A/B as well as with C. reinhardtii …
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Surface Polysaccharides of Francisella tularensis: Further Characterization, Role in Virulence, and Application to Novel Vaccine Strategies
… to virulence, biofilm formation, and role in vaccine development. In addition, this dissertation will also investigate the use of a novel vaccine delivery vehicle, alginate microencapsulation, in increasing the efficacy of these mutant strains. F. novicida is a subspecies of F. tularensis and …
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Mechanisms Involved in Enhanced Protection Against Gram Negative Bacterium Francisella tularensis Utilizing an FcR Targeted Vaccine Platform
… and research has failed to develop an effective vaccine. Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including F. tularensis, utilize the …
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