Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"live-attenuated"”.
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DENVax live attenuated chimeric dengue vaccine
… using different technologies including a live attenuated virus vaccine, DNA vaccine, and a chimeric vaccine in the yellow fever virus vaccine backbone. Inviragen, Inc., a biotech company, in collaboration with the Center for Disease Control and Prevention (CDC), is developing a chimeric …
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Production and Testing of a Novel Live-Attenuated Chikungunya Vaccine
… was focused on production and testing of a novel live-attenuated chikungunya virus (CHIKV) vaccine. To this end, multiple strategies were adapted from the IRES-based vaccine strategy first employed with VEEV vaccine strain, TC-83. The first strategy, CHIKV/IRESv1, was highly stable during cell …
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Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
… that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations that either restore the wild-type phenotype via reversion or compensate for the attenuating mutations by increasing virulence (pseudoreversion). …
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Characterization of Candidate Mutations for Use in a Live Attenuated West Nile Virus Vaccine
… for related flaviviruses indicate that a live attenuated vaccine based on the full-length WNV genome will likely induce the most robust protective immune response compared to other vaccination strategies. This dissertation describes investigation of potentially attenuating mutations in WNV …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also tested as a potential strategy for use during an outbreak when quick protective …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA at once was also tested as a potential strategy for use during an outbreak when quick protective …
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Development and Evaluation of Selected Chemoprophylaxis Candidates and a Candidate Live-Attenuated Vaccine for Prevention of Histomoniasis in Turkeys
… candidates as well as an in vitro live-attenuated vaccine candidate Histomonas meleagridis for prevention of histomoniasis. Chapter one addresses deoxycholic acid and a biliogenic diet intended to endogenously increase production of this secondary bile acid. Deoxycholic acid was …
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Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease: Characterization of a potential live-attenuated vaccine candidate
… to the host against plague, we developed a live-attenuated vaccine strain by deleting Braun lipoprotein (lpp) and plasminogen-activating protease (pla) genes from Y. pestis CO92. The lpp pla double isogenic mutant was highly attenuated in evoking both bubonic and pneumonic plague in a …
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Investigations of enterotoxigenic E. Coli (ETEC) intestinal colonization in neonatal mice and human shedding of panchol, a new live attenuated oral cholera vaccine
… countries are killed whole cells, however, new live attenuated oral cholera vaccines (OCV) are in development and offer significant advantages. PanChol is a live attenuated OCV entering phase I trials. SPECIFIC AIMS: To propel studies of ETEC pathogenesis, I attempted to create a suckling mouse …
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Induction of Long-Term Immune Responses to Protect Mice against Pneumonic Plague: Development and Testing of Novel Live-Attenuated Mutants of Yersinia pestis CO92
… against the plague, we developed three novel live-attenuated vaccine strains. These mutants were either deleted for genes encoding Braun lipoprotein (Lpp), an acetyltransferase (MsbB), the attachment invasion locus (Ail), and/or the plasminogen-activator protease (Pla) creating the Δlpp ΔmsbB …
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Development of plant-produced Bluetongue virus vaccines
… in 2006 during which high mortality rates of livestock were reported. The only vaccines currently approved and commercially available for use are live-attenuated or inactivated virus strains and although these are effective, there is the risk of reversion in the case of live-attenuated strains …
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
Traditional vaccines consisting of live attenuated pathogens or inactivated toxins cannot be readily applied to the more challenging diseases of the present e.g. hepatitis C and the human immunodeficiency virus. As such, there is a need to develop new methods of priming the immune system against …
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
… In some countries in Africa, inactivated and/or live-attenuated vaccines have been available for vaccinations of susceptible ruminants. In the U.S., a live-attenuated MP-12 vaccine strain was conditionally licensed for animal use, whereas it is also an Investigational New Drug for clinical …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… hosts. In mouse models, the mutants were attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; in contrast to the NS1 mutant, the knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… hosts. In mouse models, the mutants were attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; in contrast to the NS1 mutant, the knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust …
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Using machine learning to increase the predictive value of humanized mouse models for the human immune response to YFV-17D
… a stronger immune response after exposure to the live attenuated yellow fever vaccine (YFV17D). Additionally, semi-supervised machine learning algorithms have been shown to further uncover translational insights from mouse models. I hypothesized that these strategies may be synergistic when …
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Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
… the Yucatan Peninsula. Almost 300 years later, a live-attenuated vaccine against yellow fever virus, the causative agent of yellow fever, was successfully derived by serial passage of Asibi virus 176 times in chick and mouse embryo tissue. The resulting vaccine strain, 17D, gave rise to all …
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Investigations into DNA vaccination against Channel Catfish Virus
… Comparisons were made between published live attenuated CCVTK-, DNA vaccines (KN59 and KN6), and DNA vaccines tested in this study. In all experiments, no protection was observed. Multiple groups of vaccines delivered per fish were tested for efficacy and protection was not observed. The …
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Pertussis: Advances in Vaccine Development and Disease Control Strategies
… and development, including mRNA vaccines and live-attenuated vaccines, as well as other control strategies. The thesis highlights the limitations of current acellular vaccines in inducing long-term immunity and addresses challenges such as waning immunity, pathogen evolution, and variability …
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Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens
… after two weeks. In a challenge study with the live virus, the VLP vaccinated chickens elicited S protein specific antibodies at a level comparable to those elicited by those vaccinated with a live-attenuated vaccine mix (IBV Ma-5 and 4-91 vaccines) with geometric mean HI titres of 6.8 and 7.2 …
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