Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"lithium treatment"”.
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
… therapy (ECT) and pharmacological treatment with lithium have been used in the treatment of mood disorders for over 70 respectively 60 years, but the mechanisms behind their therapeutic effects remain elusive. We have previously shown increased neurogenesis and NG2 cell …
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Valutazione del rischio genetico di comportamento suicidario nel disturbo bipolare: analisi di 737 pedigrees
… behavior. Other clinical factors, such as treatment with lithium can reduce the suicide risk in patients with MAD. In this work the results of the distribution of suicidal behavior in a large sample of families with bipolar-spectrum disorder, and its relation to family history of MAD and …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… the brain. Furthermore, to study the effects of lithium on the brain FA-EAs and ECs to further understand the neuroprotective effects of lithium neuroprotective action on neuroinflammation as induced by LPS. Finally to examine if circulating oxysterols are linked to the prevalence of ALS and …
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Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy
… therapy (ECT) is a well-established treatment for severe depressive disorder, but its clinical use has been limited by concerns about side effects such as memory disturbances. Despite over 70 years in clinical use, the exact mechanisms of action behind the therapeutic or adverse …
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Disturbo bipolare e cefalea a grappolo: identificazione di geni e pathway molecolari e loro potenziale coinvolgimento nella risposta alla terapia con sali di litio tramite analisi dei profili di espressione genome‐wide
… and more important positive clinical response to lithium and valproate treatments in a significant proportion of treated patients. In the present study, we sought to explore whether BD and CH patients responders to lithium share common molecular pathways potentially involved in predisposing to …
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Involvement of microRNAs and their targeted genes in the pharmacogenomics of lithium response in bipolar disorder: a genome wide study
… affects approximately 1-2% of the population. Lithium is a mood stabilizer used as first line treatment of BD episodes and for maintenance. Despite 30% of patients show full remission of symptoms under chronic treatment, a high percentage of patients do not respond sufficiently. Moreover, …
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The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study
Lithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and lithium-responders have an increased frequency of BPD among …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
… In a subsequent study, the therapeutic effect of lithium, a mood stabilizer and a common treatment for Bipolar Disorder (BD) is being investigated. Lithium has antidepressant and antimanic effects in patients with BD that can be recapitulated in animal models. While lithium is effective as a mood …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… processes behind HAND. Adjuvant mitigating treatments are therefore prudent. Lithium treatment is known to promote neuronal brain-derived neurotrophic factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… of behavior that can partially be rescued by lithium treatment. We next identified the N-type calcium channels as a presynaptic substrate of Cdk5. We described how Cdk5-mediated phosphorylation of the N-type calcium channel increased calcium influx and channel open probability. This in turn …
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스트레스에 의한 Long-term potentiation (LTP)의 저하를 감소시키는 리튬의 효과
… have demonstrated neuroprotective actions of lithium in vivo and in vitro, including prevention of neuronal apoptosis and stress-induced structural remodeling. Enhancement of LTP by lithium treatment was reported by an in vitro study. On the other hand, some studies have reported the …
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Lithium protects the juvenile brain from ionizing radiation
Radiotherapy used in the treatment of brain tumours in children results in a range of cognitive dysfunctions that impact the quality of life in the surviving population. In past decades, great strides were made in understanding the cellular and molecular aetiology of these deficits. Postnatal …
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Células del neuroepitelio olfativo de pacientes para la búsqueda de un modelo in vitro e in vivo en trastornos psiquiátricos
… al litio en pacientes con BD que responden (lithium responder, LR) o no al litio (lithium non responder, LNR), y descubrir nuevas dianas terapéuticas. Además, estudiaremos el potencial de diferenciación neural de las células derivadas del neuroepitelio olfativo in vivo. Las células del ONE de …