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Showing 1 to 15 of 15 for “"lithium amide"”.
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Zincative Functionalization of C–H Bonds Using Lithium Amide Zincate Bases
… the expanded scope of substrates is the use of a lithium zincate base, Li[ZnEt2TMP] which can coordinate to a variety of common functionalities to direct zincation. The mild reaction conditions and compatibility with functional groups such as esters, nitriles and halides make this method …
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Formation and electrolysis of disubstituted alkali-metal amides
… the products of the electrolysis of dimethyl lithium amide.
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An investigation of direct C-alkylation of 2,4-oxazolidinedione and 5-phenyl-2,4-oxazolidinedione utilizing dialkali salt intermediates
… was obtained using 2.1 equivalents of lithium amide in liquid ammonia followed by alkylation with 1.1 equivalents of benzyl chloride. Although the yield of 5-benzyl-5-phenyl-2,4-oxazolidinedione using lithium diisopropylamide in THF-hexane-HMPA was only 39% (determined by pmr analysis), …
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A structural and reactivity study of lithium molybdenum nitride
… describes the preparation and reactivity of lithium molybdenum nitride samples and the preparation and characterisation of the nitride precursors. It has been shown that samples containing lithium molybdenum nitride (LiMoN2) can be formed from the direct ammonolysis of lithium molybdate …
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Synthesis and Characterisation of Phosphenium Ions with Aromatic Amido Substituents
… results in the production of the appropriate lithium amide salts (2) followed by subsequent reaction with PCl3, which yields the chlorophosphines 3. Reaction of 3 with a halogen abstracting reagent such as AlCl3 (or TMSOTf) results in the formation of phosphenium ions (4), which were studied …
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The formation and chemistry of certain heterocyclic dianions
… with two molecular equivalents of sodium amide in liquid ammonia. The dianion underwent C-alkylation with numerous alkyl halides, to form 2-alkylglutarimides. Certain of these 2-alkyl derivatives were hydrolyzed to the corresponding 2-alkylglutaric acids. Carbonyl addition reactions of the …
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Group 11 'Ate Bases: Towards an Understanding of Solid- and Solution-State Structures
Lithium bis(amido)cuprates are an important class of bimetallic base, which can chemo- and regioselectively metalate aromatic compounds, via directed ortho cupration (DoCu). This thesis begins with an introduction to aspects of the chemistry of organolithium compounds, group 11 organometallic …
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Mixed anion complex hydrides for hydrogen storage
… and characterised. The structures of three amide-borohydride complex hydrides of lithium and sodium, Li\(_4\)BH\(_4\)(NH\(_2\))\(_3\), Li\(_2\)BH\(_4\)NH\(_2\) and Na\(_2\)BH\(_4\)NH\(_2\), have been solved by powder diffraction methods and characterised by infrared and Raman spectroscopy. …
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2-substituted-1, 3-dioxan-5-ones : synthesis, reactions and synthetic applications
… were shown to easily form corresponding lithium, boron and titanium enolates. The 2-'tert'-butyl-2-methyl-1,3-dioxan-5-one was deprotonated enantioselectively in 90% e.e. with the aid of chiral lithium amide derived from (R)- or (S)-'N'-(2,2,2-trifluoroethyl)-1-phenylethylamine. This …
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Chiral concepts in s-block metal chemistry
… different adducts of the synthetically important lithium tris(n-butyl)magnesiate LiMg(nBu)3 (1). Complex 1 has been co-complexed with different ligands to form the complexes [(TMPDA)·Li(u-nBu)2Mg(u-nBu)]2 (48), [(PMDETA)·Li(u-nBu)(nBu)Mg(u-nBu)]2 (49) [{(R,R)-TMCDA}·Li(u-nBu)2Mg(u-nBu)]2 (51), …
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Chemistry of low and medium-valent niobium complexes supported by anionic amides.
… with LDA in a stoichiometric ratio of 1:3 Nb/Lithium amide, resulted in a new diamagnetic niobium (II) cluster (TMEDA)3Nb2Cl5Li (2.1) with a very short Nb≡Nb bond. Similarly, reaction of NbCl4(THF) 2 with 2 equiv. of Cy2NLi caused the reduction of the metal center to produce a …
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Synthesis of multicomponent heavy alkali metal amide systems and extensions to zirconium chemistry
… an introduction on reported homometallic lithium, sodium and potassium salts of the bulky utility amines [HMDS(H), TMP(H) and DA(H)]. The second section, Chapter 2−Chapter 5, includes the achieved results obtained during the course of this PhD work based on the homometallic alkali metal …
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Chemistry with chiral lithium amides: enantiotopic group and face-selective reactions
… and tropinone.The aldol reaction between the lithium enolate of 1,4-cyclohexanedione monoethylene ketal and benzaldehyde demonstrated the high diastereoselectivity (up to 98% de) and the moderate to high enantioselectivity (up to 75% ee) induced by those chiral lithium amides. On the other …
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Flexible access to an array of enantiomerically-enriched oxabisipidines and their use as chiral ligands in asymmetric synthesis
… formation of both the corresponding magnesium bisamide and lithium amide species. Such endeavours indicated that the chiral amine species must be introduced as the bis-HCl salt. Investigations into the use of such amide base species in the deprotonation of 4-tert-butylcyclohexanone to generate the …
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Stereoselective and Economical Methods for Chemical Synthesis of Essential Medicines
… of racemic bedaquiline simply by changing the lithium amide base and including a salt additive. We anticipate facile implementation of these improvements on manufacturing scale that will increase throughput of this essential medication. Chapter 4: Synthesis of a Key Precursor to Benzodiazepines …