Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"listeriolysin O"”.
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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
… the host cell cytosol via the pore forming toxin listeriolysin O (LLO) and infects a variety of cell types including dendritic cells (DC). Our laboratory and others have shown that optimal DC maturation occurs when <italic>Listeria</italic> gain access to the host cytosol, and this correlates with …
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Cholesterol-Dependent Cytolysins and Perforin: Similar Pore-Forming Mechanisms in Pathogenic Attack and Human Immune Defense
… on two bacterial CDCs, Perfringolysin O and Listeriolysin O, and on the human protein Perforin, which is involved in the apoptotic pathway facilitating Granzyme release. In the literature, two possible configurations of CDCs and Perforin pores are proposed: ring and arc structures that could …
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Untersuchungen zur Aufklärung der In-vivo-Funktion des Zytolysins ClyA von Escherichia coli
… Listeria monocytogenes ein porenbildendes Toxin, Listeriolysin O (LLO), nach der Invasion in phagozytische Zellen die Befreiung der Bakterien aus dem Phagosom ermöglicht. Es stellte sich deshalb die Frage, ob ClyA bei EIECs möglicherweise eine ähnliche Rolle spielt. Um dies herauszufinden, wurde …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… by expressing internalin A and B, then secretes listeriolysin O (LLO), a virulence factor forming pores on the phagosome membrane to escape into the cytosol. Macrophages can phagocytose invading pathogens and induce innate inflammatory responses. Production of cytokines and eicosanoids by antigen …
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Catalase, superoxide dismutase, and hemolysin in the virulence of Listeria monocytogenes
… for catalase, superoxide dismutase (SOD), and listeriolysin O (LLO) activities. The two strains having the lowest catalase activities also possessed the lowest SOD activities. Exogenous hydrogen peroxide was added to suspensions of four L. monocytogenes strains; strains producing the highest …
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Host lncRNAs recognize invading bacteria and aid against infection by associating with polysomes
… for the expression of the main virulent factor Listeriolysin O (LLO-deficient (∆LLO) strain). Taking advantage of these strains, I explored whether the pore forming toxin, LLO, is able to trigger a host toxin-specific translational controls. To address this question, I massively employed …
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Investigation of the role of the toxins perfringolysin O (PFO) and sialidase in Clostridium perfringens gas gangrene infections
Clostridium perfringens is the causative agent of gas gangrene. A lethal infection in mice requires a large inoculum suggesting that the immune system is involved in inhibiting disease. Human monocytic cells and neutrophils killed C. perfringens in vitro when complement was present. Macrophages and …