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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"liquid chromatography - mass spectrometry"”.
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Investigation of resveratrol metabolism using liquid chromatography-mass spectrometry.
Investigation of resveratrol metabolism using liquid chromatography-mass spectrometry.
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Liquid chromatography-mass spectrometry, an evolution in doping analysis
… of LC-MS in the field of doping analysis, mass spectrometrical information was acquired with capillary GC-MS. This analytical technique is only suitable for volatile compounds. Because doping agents include polar functional groups in their structure, their volatility is limited and prior to …
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Liquid chromatography-mass spectrometry-based neuropeptide characterizations across neuronal models
… depends on the available of suitable tools. Mass spectrometry (MS), coupled to liquid chromatography (LC) and assisted by appropriate sampling protocols, has been successfully applied to unambiguously characterize neuropeptides and their post-translational modifications. No individual MS …
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Liquid Chromatography – Mass Spectrometry for Protein Biomarker Discovery in Pancreatic Adenocarcinoma
… in its early stages. Recent developments in liquid chromatography – mass spectrometry (LC-MS) technology have made it possible to profile proteins associated with disease in a comprehensive manner. Within this thesis current LC-MS methodology was applied to the problem of pancreatic cancer. A …
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Proteomics and peptidomics for investigating metabolic and neurological disorders via liquid chromatography-mass spectrometry
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Development of Liquid Chromatography Mass Spectrometry technique for evaluation and differentiation of plant derived isomers
… enhance the desired therapeutic effect. Herein, liquid chromatography quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) method capable of distinguishing between these isomers was developed.
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Characterization of Microorganisms of Interest to Homeland Security and Public Health Utilizing Liquid Chromatography/Mass Spectrometry
Liquid chromatography/quadrupole time of flight mass spectrometry (LC/QTOF MS) utilizing electrospray ionization was employed to monitor protein expression in Escherichia coli and Shigella organisms. Automated charge state deconvolution, spectral subtraction and spectral mirroring were used to …
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Development of liquid chromatography mass spectrometry methods for the monitoring of ropivacaine, endogenous steroids and dihydroartemisinin
… plasma using equilibrium dialysis and HILIC chromatography coupled with a high resolution mass spectrometery. In this chapter a highly sensitive method for the determination of the free and bound portion of ropivacaine in patients undergoing knee and hip joint surgery was developed. Patient …
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Application of High-Performance Liquid-Chromatography Mass-Spectrometry Platform to Study Metabolism and Epigenetic Control of Metabolism
… and diabetes. Our lab built a High-Performance Liquid-Chromatography Mass-Spectrometry (HPLC-MS) based metabolomics platform to analyze metabolites from mammalian cells, spent cellular media, and model organisms such as C. elegans. We used C. elegans to elucidate the metabolic changes seen after …
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Targeted and untargeted metabolomic profiling of human serum, urine and brain by liquid chromatography mass spectrometry (LC-MS)
… used in combination with hydrophilic interaction liquid chromatography and high resolution mass spectrometry to analyse the sugars in post-mortem human brain. The samples were collected from six control brain samples and eighteen samples from individuals who had suffered from schizophrenia, …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… by a two-dimensional nano-ultrahigh-performance liquid chromatography parallel reaction monitoring/high-resolution mass spectrometry (2D-nano-UHPLC-PRM/HRMS) platform. Secreted HMGB1 was immunoprecipitated with a stable isotope-labeled HMGB1 internal standard followed by CD3-acetylation and …
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Separation and quantification of fourteen chemical forms of fat soluble vitamins in food matrices using solid phase extraction coupled with liquid chromatography – mass spectrometry
… were studied. Quantification was conducted using liquid chromatography-mass spectrometry (LC-MS). All fourteen fat-soluble vitamins were found to be non-polar in nature; beta-carotene was found to be the most non-polar vitamin in the group, followed by vitamin esters. Tocopherols, ketones …
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The Reconstruction of Climate in Beringia by analysis of Glycerol Dialkyl Glycerol Tetraether (GDGT) Distributions using High Performance Liquid Chromatography – Mass Spectrometry (HPLC-MS).
… extracts were analysed by high-performance liquid chromatography coupled via atmospheric pressure chemical ionisation to mass spectrometric detection (HPLC-APCI-MS). Glycerol dialkyl glycerol tetraether (GDGT) ratios within the extracts were used to reconstruct sea surface temperatures …
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The use of liquid-chromatography mass spectrometry for the absolute quantitation for bio-analytes: fro small molecular mass compounds towards larger molecular mass proteins
… the absolute quantitation of the small molecular mass compounds pyrimethamine/sulfamethoxypyrazine and glycopyrrolate. Moreover, also for the larger molecular mass protein cystatin C was mass spectrometry investigated for its absolute quantitation. This, by means of marker peptides. In this way, …
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Development of liquid chromatography-mass spectrometry protocols for quantification of imidacloprid in pig urine and for analysis of 5α-cyprinol sulfate metabolism in zebrafish
Liquid chromatography-mass spectrometry (LC/MS) is a robust and sensitive technique used for the separation, identification, and quantification of small molecules within a mixed biological sample. It is commonly used in metabolomic analyses, which complement genomic, transcriptomic, and proteomic …
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Penetration of Carcinogen Across Porcine Esophagus and Applications of Disposable Pipette Extraction for Forensic Toxicology and Food Safety by Gas and Liquid Chromatography/Mass Spectrometry
<p>This dissertation focuses on the chemical analyses of N-nitrosonornicotine from (NNN) porcine esophageal tissue, benzodiazepines (BZDs) and steroids in urine, and toxins such as melamine and pesticides in various foods. The effects of menthol, ethanol and also acetaldehyde on the flux of NNN …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
… the high specificity and sensitivity of tandem mass spectrometry (MS/MS) with the high separation ability of high performance liquid chromatography (HPLC) facilitates the sensitive and specific analysis in complex matrices like urine and blood. In this body of work, new methods were developed …
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Applications of Disposable Pipette Extraction for Analysis of Drugs of Abuse Vitamin D Metabolism Testosterone and Inborn Errors of Metabolism by Gas and Liquid Chromatography/mass Spectrometry
… is 82.5%. </p> <p> A fast, simple and accurate liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed by using an efficient disposable pipette extraction (DPX) technique, which could simultaneously analyze 51 drugs within 6 minutes. The method has an accuracy of 97 to …
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