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Showing 1 to 13 of 13 for “"lipoteichoic acid"”.
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Rational Development of New Inhibitors of Lipoteichoic Acid Synthase
… for novel anti-bacterial targets. Recently, the lipoteichoic acid (LTA) biosynthesis pathway has emerged as a potential anti-bacterial target. LTA is an anionic polymer found on the cell envelope of Gram-positive bacteria. It comprises of repeating units of glycerol-phosphate (GroP) and is …
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Staphylococcus aureus의 Lipoteichoic acid(LTA)에 의한 사람의 정상 코 점막 상피세포에서의 MMP와 TIMP의 발현
… 2. Air Liquid Interface-culture(ALI-culture) B. Lipoteichoic acid(LTA) 처리 C. MTT assay D. RNA 추출 및 cDNA 합성, PCR E. Enzyme-linked immunosorbent assay(ELISA) F. Gelatin zymography 1. Gelatinase B의 준비, 활성화 2. Gelatinase B의 전기영동, 기질-효소 간 반응 3. 발현된 band의 염색, 결과의 수치화 G. Western blot 1. LTA 처리, 단백질 정량 …
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
… of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) isolated from Staphylococcus aureus.Human middle ear epithelial cells (HMEE) were treated with LTA. Changes of MMP and TIMP and signal transduction were examined by PCR, ELISA, zymography and western blot. LTA isolated from …
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Studies on the Teichoic Acids of the Pneumococcus
… of segregation of the pneumococcal wall teichoic acid during cell growth and division. Teichoic acid was labeled with <sup> 3</sup>H-choline (a teichoic acid-specific constituent of pneumococci) or an analogue, and its distribution among progeny cells over several generations was followed by …
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Fumarate Inhibits TNF-α Release
… lipopolysaccharide (LPS) and Gram-positive lipoteichoic acid (LTA). And respond by releasing tumor necrosis factor-α (TNF-α). While beneficial for neutralizing acute pathogen exposure, prolonged TNF-α release results in chronic inflammation and tissue damage. In the present study, we …
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Modulation of Innate Immune Cell Signaling Pathways by Staphylococcus aureus and Omnigen-AF®
… of DC included ultraviolet light (UV) and lipoteichoic acid (LTA). Results indicate that γ-irradiated S. aureus can inhibit UV-induced apoptosis by upregulating LTA. This research provides information about S. aureus infections, but further research is needed to improve responses to this …
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Mechanistic Study of Antimicrobial Cyclic Peptide [R4W4] Antibacterial Effectiveness against Methicillin-resistant Staphylococcus aureus (MRSA)
… cytoplasmic membrane depolarization, and Lipoteichoic acid (LTA) binding affinity. [R<sub>4</sub>W<sub>4</sub>] exhibits bactericidal activity against bacterial isolates (MBC/MIC £ 4), with a synergistic effect with gentamicin against <em>E. coli</em> (FICI=0.3), but not against MRSA …
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The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
… and after stimulation with S. aureus-derived lipoteichoic acid (LTA). DESeq2 and g:Profiler were used for differential expression analysis and functional annotation, respectively. Results: CHIP subjects had increased serum protein titers of MPO (p=0.006) and LTF (p=0.001) compared to controls, …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… of LL-37 is due to hydrophobic amino acids. We were able, by removing hydrophobic amino acids from the N-terminal of LL-37, to generate less cytotoxic peptides with retained antimicrobial and LPS–neutralizing actions in serum. By using computer simulation we identified an active domain …
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Purification and characterisation of the lipid macroamphiphiles of propionibacterium acnes.
… the extraction and consequent purification of lipoteichoic acid (LTA) from S. aureus by hydrophobic interaction chromatography (HIC), a similar method was applied to an extract from P. acnes. The resulting amphiphilic fractions were analysed using SDS-PAGE and found to contain two discrete …
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Comparative analysis of two attachment variants of butyrivibrio fibrisolvens.
… as well as its monosaccharide and fatty acid composition between S and L cells was compared. The cell associated, secreted or total EP was isolated using gradient centrifugation, cell free medium (Stack 1988) or plate (Berri and Rollings 1995) methods, respectively. The effect of carbon …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… the role of an insulin-mimetic, the α-lipoic acid (α-LA), in PBGD-silenced hepatocytes and in a genetic AIP murine model, as it showed beneficial effects in porphyria cutanea tarda in previous findings. α-LA enhanced hepatocellular heme pool, glycolysis, and ATP production in in vitro model …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… bacterial cell components, such as lipoteichoic acid, peptidoglycan, and bacterial toxin pneumolysin. Adenosine has strong immunosuppressive and anti-inflammatory effects mediated by A2A receptor (A2AR) expressed on immune cells. We investigated the effect of A2AR agonist, ATL313, as …