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Showing 1 to 13 of 13 for “"liposomal delivery"”.
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… in combination.</p><p>Here an alternative drug delivery technique using drug-loaded liposomes is investigated that may allow for increased drug efficacy and, possibly, reduced unwanted side effects. Liposomes can encapsulate drugs and deliver them directly to specific cells. This research …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
<p>Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for …
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A cancer-targeting liposomal delivery system for photodynamic diagnosis and therapy of cancers in peritoneal cavity
… and potential targeting ability, I proposed a liposomal delivery system, Folic-modified liposome (FL). The goal of this study is to take advantage of this observation by developing a FL system of MAL for photodynamic diagnosis and therapy of cancers in the peritoneal cavity in a more specific …
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Exploring folate conjugated liposomal delivery of thymoquinone as a novel targeted treatment for human papillomavirus associated cancers
… of free chemotherapeutic drugs has been the main delivery route in cancer patients despite its several drawbacks. Besides the adverse side effects, higher doses of these drugs are required for them to reach the tumour sites which eventually may lead to the development of drug resistance and limit …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
Lung cancer is one of the main causes of death worldwide, with most patients suffering from an advanced unresectable or metastatic non-small cell lung cancer. The mortality trends are mostly related to patterns of tobacco use, specifically from cigarettes. Tobacco is the basic etiological agent …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
Lung cancer is one of the main causes of death worldwide, with most patients suffering from an advanced unresectable or metastatic non-small cell lung cancer. The mortality trends are mostly related to patterns of tobacco use, specifically from cigarettes. Tobacco is the basic etiological agent …
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Synthesis of Peptide Nucleic Acid (PNA) and Entrapment of PNA into Liposomes
… co-transfection with DNA. Among the different delivery strategies, liposomes are a potential way to delivery PNA into cells since liposomes can protect various molecules from the external medium and can deliver molecules directly into cells. Moreover, it is also possible to specifically target …
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Strategies for targeting cancer: small molecules, epigenetics and drug design
… small molecule interactions, metallocage drug delivery, epigenetics and protein activity inhibition. The first part of my research focused on the significance of Cisplatin as a chemotherapeutic. My findings indicate the unexpected speciation of platinum in the human body as a revelation to be …
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Development and In-Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma
… of drug resistant pancreatic cancer, targeted delivery of the drug to the tumor is the need of the hour. Of all the various approaches, liposomal delivery has emerged as a prime candidate. While surface modification with polyethylene glycol (PEG) conjugates remains the most commonly used …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… agent for CRPC and explores targeted drug delivery strategies to enhance its efficacy and specificity6. Eupenifeldin demonstrated potent cytotoxicity in multiple CRPC cell lines, with nanomolar IC₅₀ values and significantly lower toxicity toward non-malignant prostate epithelial cells, …
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… than PLA2-GIIA as a typical example. Drug-loaded liposomal membranes could be impaired by sPLA2, triggering drug release at the site of sPLA2 expression. This class of enzymes is therefore an interesting target for developing drug delivery systems for diseases where PLA2s are overexpressed, such …
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Probes of tocopherol biochemistry: fluorophores, imaging agents, and fake antioxidants
… able to express α-TTP, however the exact path of delivery between these cells is still unclear. A technique called fluorescent microscopy allows the tracking of fluorescent molecules in cells to find their location and interactions with other parts of the cell. The focus of this study is the …