Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"lipoprotein metabolism"”.
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Effects of dietary fat saturation on lipoprotein metabolism in rodents and humans
… However, amongst SFA, the effects on plasma lipoproteins are variable. Thus, we hypothesized that specific combinations of dietary SFA will not contribute to an adverse lipid profile. </p> <p> We used gerbils and hamsters as our study models to determine the effects of Lauric and Myristic …
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Roles of human plasma phospholipid transfer protein in high-density lipoprotein metabolism
… than apo-A-I. However, the apoproteins added to lipoproteins did not yield significant effects. The PL transfer activity of PLTP was considerably higher than that of LTP, especially when synthetic lipid particles rather than natural lipoproteins were used as donor particles. Plasma PLTP and LTP …
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Association of dietary and phosphatidylcholine supplement intake with cardio-metabolic biomarkers among normo- and hyperlipidaemic individuals
… of cellular membranes and plays a vital role in lipoprotein metabolism. Many studies have investigated the effects of phosphatidylcholine on lipid profiles; however, results have been inconsistent, therefore the precise effects of dietary phosphatidylcholine remain unclear. This project aimed to: …
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Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
… of atherosclerosis and CHD, inflammation and lipoprotein lipid metabolism. The first part of this thesis demonstrates that B- and T-lymphocytes do not play a significant role in development or progression of atherosclerosis or CHD in SR-BI/apoE dKO mice. More importantly, this study eliminates …
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Mechanism of lipid disorder in HIV infection: apolipoprotein-B kinetics, fat distribution, insulin resistance and adipocytokines in patients taking protease inhibitors or non-nucleoside reverse transcriptase inhibitors
… insulin resistance (HOMA), adipocytokine and apolipoprotein-B (apoB) kinetics was investigated in 12 HIV negative controls and 55 HIV-infected patients including antiretroviral treatment-naïve patients (n=15) and patients taking two nucleoside analogues plus either a protease inhibitor (PI, n=15) …
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Apoliprotein B metabolism in hamster livers, studied in vitro
This study aimed to investigate lipoprotein metabolism in male hamsters fed diets considered to be atherogenic in humans. Livers from adult male hamsters were selected to study aspects of apolipoprotein B metabolism. Isolated hepatocytes in suspension were compared with those maintained under …
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
Background/aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determine disease outcome in hepatitis B virus (HBV) infected individuals, …
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Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models
… effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen …
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… biosynthesis, fatty acid utilization, and lipoprotein metabolism. Affecting global energy homeostasis, this programmatic shift in hepatic expression may contribute to longevity by influencing bioenergetic and oxidative reactions occurring within mitochondria, ER, and peroxisomes. …
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Lipoprotein lipidomics in obesity-associated metabolic and hepatic disorders
… to evolve to hepatocellular carcinoma and CVD. Lipoprotein dysmetabolism is crucial to both MetS and NAFLD and few studies have investigated the circulating lipidome, defined as the complete lipid profile in a specific tissue/biofluid, in these conditions. The work contained in this thesis …
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Familial hypercholesterolaemia - the Cape Town experience
… on South African founder effects is given. Lipoprotein metabolism is briefly reviewed to enable a better understanding of the pathology and complications of the disease. Demographics of patients attending the clinic, their clinical signs, lipid profiles and complications are analysed in the …
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Genetic studies of cardiometabolic traits
… (PDH) complex” pathway and intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and circulating cholesterol measurements. In addition, I demonstrated that rare “protective” variation in lipoprotein metabolism genes was present in the lower tails of four measurements which are CVD …
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Apolipoprotein biosynthesis and turnover in mammalian small intestine
… for the synthesis and secretion of plasma apolipoproteins, and contributes significantly to overall whole-body lipid dynamics. A prominent feature of the small intestine is its exposure to periodic loads of meals often containing dramatically varying amounts or types of food components, …
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Receptor-mediated endocytosis of low density lipoproteins in aortic endothelial cells
Lipoprotein binding and metabolism in actively-dividing (subconfluent) and quiescent (postconfluent) bovine aortic endothelial cells (ECs) were qualitatively investigated by fluorescence microscopy using dioctadecylindocarbocyanine-labelled lipoproteins and by indirect immunofluorescence …
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Type 2 diabetes mellitus and dyslipidaemia: effects of genetic variation in African populations
Background: Low-density lipoproteins (LDL) have been associated with damage to the cardiovascular system in patients with type 2 diabetes mellitus (T2DM). These patients are two (2X) to four (4X) times more likely to develop cardiovascular diseases (CVD) compared to non-diabetic patients due to …