Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"lipoplexes"”.
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Endocytosis mechanism of poly- and lipoplexes in siRNA delivery in HeLa cells
… and create lipid- or polymer based particles (lipoplexes or polyplexes). The materials that are used as the delivery vectors can mediate the uptake and the release of siRNA in the cytosol. In order to synthesize newer generation of the delivery materials, it is paramount to know through which …
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Quo vadis: quantitative evaluation of intracellular kinetics of siRNA delivered by poly-and-lipoplexes
Small interfering RNA (siRNA), when delivered to cells, is able to elicit a potent post transcriptional gene silencing with enormous therapeutic potential. It has been demonstrated that siRNA is able to tackle a wide range of conditions that include viral infections, cancer, immunological …
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Synthesis, characterization, and evaluation of photo-active amphiphiles for gene delivery applications
… release, and cellular uptake behaviors of lipoplexes were found to be dependent on lipid composition and resulting supramolecular structures. The transfection efficiency of the photo-active lipoplexes was further affected by variables associated with cellular incubation and UV exposure. …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… currently available drug carriers (pDNA or siRNA lipoplexes and doxorubicin-liposomes) was significantly improved by microbubble coupling and ultrasound exposure. This enables us to obtain a space and time controlled drug delivery guided by ultrasound. The fact that ultrasound and microbubbles …
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Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces
… treatment on compaction of nucleic acids into lipoplexes and I have established a high temperature annealing method for this purpose. This novel formulation technique allowed a substantial reduction of the amount of amphiphiles required to compact a specific amount of nucleic acids. This in …
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
… in the trans-aminocyclohexanol-based lipoplexes.</p>
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Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery
… a variety of TACH-lipids were incorporated into lipoplexes together with the cationic lipid DOTAP to mediate DNA transfection in Bl6F1 and HeLa cancer cell lines. The lipoplex comprising TACH-lipid 3o (R 1 = C 19 H 37 ; R 2 R 3 = CF 3 CH 2 NH) exhibited one to two orders of magnitude better …