Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"lipopeptides"”.
-
Novel chemical entities against tropical diseases: Peptidomimetic lipopeptides as new anti-orthoflavivirals and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives as new antimalarials
Contains fulltext : 310090.pdf (Publisher’s version ) (Open Access)
-
Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… by acting as mobile carriers of triacylated lipopeptides or lipoproteins. Chapter Three describes the measurement of interactions between TLRs and lipopeptides to assess the possible competition between TLR1 and TLR10 for lipopeptides and the TLR2 co-receptor. Using microtiter plate assays, …
-
Endophytes as source of polypeptide and polyketide antibiotics fengycin and bacillaene
… as biosurfactant. Despite the great potential of lipopeptides, the industrial use of these antibiotics is still limited due to their high production costs, which result primarily from low strain productivity and difficulties in bioprocess design as well as downstream processing. Therefore, a …
-
Isolation, identification, and characterization of antibiotic-producing microorganisms from soil
… characterized by the abundance of dipeptides and lipopeptides, such as surfactins, suggesting that the combination of cyclopeptides and lipopeptides together could be the attribute of the enhanced antimicrobial activity observed in agar well diffusion (Chapter 4). The current study further …
-
Biological activity and regulation of cyclic lipopeptide production in Pseudomonas corrugata and Pseudomonas mediterranea
… The interest of our work focused on cyclic lipopeptides (CLPs) that are surface active molecules with antibacterial, antifungal and cytotoxic properties. P. corrugata is known to produce two kinds of cyclic lipopeptides, corpeptins and cormycin A. Investigations on P. corrugata strain …
-
Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… of antibiotics. Herein, the synthesis of cyclic lipopeptides based on the tridecaptins is reported. In particular, analogues where residues D-Trp5 and Phe9 were substituted for D-Cys and Cys respectively were synthesized and cross-linked with various benzylic linkers of various sizes. …
-
DEVELOPMENT OF NEW PEPTIDE-BASED NANOMATERIALS AS POTENTIAL TOOLS FOR CRYOPRESERVATION OF TISSUES AND ORGANS
… acid. The secondary structure of the synthesised lipopeptides was assessed both in solution and in the solid state by CD and ATR-FTIR, respectively, whereas their tendency to self-assemble was investigated using a solvent displacement technique and characterised by Dynamic Light Scattering (DLS). …
-
Greener Surface Active Reagents: Structure, Property and Performance Relationships
… and interfacial properties of a series of lipopeptides synthesized by chemo-enzymatic reactions were studied. They were found very surface active, especially C12/oligo(L-Glu). The effects of chain length of hydrophobic moiety, composition of oligopeptide as well as aqueous chemical …
-
Regulation of The Expression and Lysine Acetylation of Pro-Inflammatory Molecules By Lipid-Modifying Enzyme (LPCAT2) in RAW264.7 Cells
… to infection by lipopolysaccharides and lipopeptides. LPCAT2 co-localises with TLR4 and prevents its translocation to the signalling site (lipid rafts) of macrophage membranes. The first response to inflammation involves infiltration of macrophages to the infected site, where they fight …
-
Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… biseokeaniamides A-C, structurally distinct lipopeptides bearing a C-terminal thiazole motif. The intrinsic reactivity of peptide C-terminal carboxylates towards electrochemical decarboxylation was reinvestigated and the electrochemically-generated N,O-acetal intermediates were subjected to a …
-
Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… biseokeaniamides A-C, structurally distinct lipopeptides bearing a C-terminal thiazole motif. The intrinsic reactivity of peptide C-terminal carboxylates towards electrochemical decarboxylation was reinvestigated and the electrochemically-generated N,O-acetal intermediates were subjected to a …
-
Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
… mutated outer surface protein A (OspA) lipopeptides could be detected by epifluorescence microscopy in both the periplasm and on the bacterial surface. These findings supported the notion that Borrelia spirochetes do not adhere to the +2/+3/+4 sorting rules established in other …
-
Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… thirty years, only the oxazolidinones and cyclic lipopeptides have been developed as novel antibiotic classes.7 One novel cyclic lipodepsipeptide antibiotic in the clinical pipeline is WAP-8294A2. WAP-8294A2 (Figure 1.0.4) was isolated from the soil bacteria Lysobacter staphylocidin (FERM BP-4900) …
-
Screening and evaluation of bacteria for the biological control of Botrytis cinerea on Vitis vinifera
Agriculture plays a significant role in food security and the economic sector. However, the agriculture industry is threatened by plant pathogenic microorganisms, with fungi accounting for 42% of plant diseases. Botrytis cinerea is the most notable of all plant pathogenic fungi. B. cinerea is …
-
Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
… of this is clinical use of echinocandins, lipopeptides inhibiting the activity of β-1,3 glucan synthase that synthesize β-1,3 glucan from UDP-Glc. Although inhibitors of other glycosyltransferases (e.g. chitin synthases) also exhibit antifungal activity, only echinocandins have been …