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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"lipogenesis"”.
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
Elevated level of lipogenic enzymes and overall lipogenesis have been reported in a wide variety of cancers and blocking the lipogenic pathway by chemical inhibitors or RNA interference causes tumor cell death by apoptosis which provides a strong rationale for targeting lipogenic pathway for the …
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Dietary amino acids and their contribution to de novo lipogenesis
… portion was not sufficient to induce de novo lipogenesis, however, the high protein meal, rich in glutamate increased de novo lipogenesis-associated triacylglycerides in plasma and liver-derived very low-density lipoprotein particles in samples from human subjects. The underlying mechanism …
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Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity
… are lipolysis (lipid mobilization) and lipogenesis (lipid formation), which are controlled by different metabolic hormones. Potential differences in these processes or hormone sensitivity may predispose OP rats to develop obesity or protect OR rats from the obese state. In experiment 1, …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
Invadopodia are membrane protrusions that facilitate matrix degradation and cellular invasion. Although cellular lipids have been implicated in several aspects of invadopodia assembly and function, the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data …
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Investigating the regulation of tumour associated lipogenesis using the model organism, Saccharomyces cerevisiae
The highly conserved mitogen activated protein kinase (MAPK) high-osmolarity glycerol (HOG) pathway plays a vital role in the ability of Saccharomyces cerevisiae cells to respond to stress conditions, primarily hyperosmotic stress. In addition, there is also evidence that the HOG pathway is …
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Lipogenesis in the Ruminant and the Influence of Diethylstilbestrol on Adipose Tissue Metabolism
Made available in DSpace on 2014-12-10T22:30:23Z (GMT). No. of bitstreams: 1 7212225.pdf: 3450549 bytes, checksum: 4ce2a4afddf3572a2782e7d050d46f60 (MD5) Previous issue date: 1971
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Utilising Yeast as a Model Organism to Deconstruct the Regulation of Tumour Associated Lipogenesis
… recent evidence suggests their role in mediating lipogenesis. Lipogenesis accompanies a variety of disease states, including the formation of brain tumours. Malignant brain tumours are rapidly growing and often invade surrounding healthy tissue, resulting in poor prognosis for the patient. The …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… is required for <italic>de novo</italic> lipogenesis in multiple cancer cell lines. Inhibition of Nampt causes a reduction in ATP levels which correlates with phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC). Inhibition of the …
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Lipogenesis and Aspects of Its Regulation in the Liver and Adipose Tissueof the Chicken and Pig
Made available in DSpace on 2015-05-12T21:45:24Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7013433.PDF: 4474555 bytes, checksum: 302e767dae8462c63a33ca1c505b1061 (MD5) Previous issue date: 1969
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The Role of Akt2 in Hepatic Lipid Metabolism
… certainly an inappropriate increase in de novo lipogenesis in the livers of individuals with hepatic steatosis, but the insulin signaling pathway involved in the control of normal, and therefore abnormal, lipogenesis remain undefined. Previous studies have demonstrated that Akt2 is critical to …
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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
… fatty liver by inhibiting hepatic de novo lipogenesis, at least in part, through protecting mice against HFD-induced insulin resistance and hyperinsulinemia, a state known to drive hepatic lipogenesis. .
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Effect of Dietary Protein and Fat, Age and Periodicity of Eating on Performance and Carcass Characteristics and on Lipogenesis and Enzymatic Activity in Adipose Tissue of the Pig
Made available in DSpace on 2015-05-12T22:36:25Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7114658.PDF: 6001534 bytes, checksum: 9b9a89413c7109b0bf75578d0f556e83 (MD5) Previous issue date: 1970
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The hormonal control of lipid metabolism in sheep
… (GH) and insulin-like growth factors (IGFs) on lipogenesis and lipid mobilization were studied to assess their likely individual contributions to overfatness in vivo. From the various measurements of lipid metabolism made, the rates of fatty acid accumulation in the tissue during the incubation …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… triacylglycerides (TAGs), in a process known as lipogenesis. TAGs are stored in large lipid droplets in the cytosol, and during fasting, or in response to physical exercise, they are hydrolysed in a process known as lipolysis, in which FAs are released into the bloodstream for use as energy …
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Quantitative analysis of carbon fluxes for fat biosynthesis in wild-type and IRS-1 knockout brown adipocytes
… by identifying key sites for regulation of lipogenesis and modulating the lipogenic fluxes may provide novel approaches to intervention of the diseases. As a first step to quantitative investigation of lipogenic fluxes from various carbon sources as related to insulin signaling, relative …
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… P.Z.I.)<br/>restored the low diabetic rate of lipogenesis to normal by 8h after<br/>feeding. Streptozotocin reduced the hepatic Vmax activities of glucokinase,<br/>ATP-citrate lyase and total acetyl CoA carboxylase. None of these<br/>enzyme activities increased when hepatic fatty acid synthesis …
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Effect of pregnancy on adipose tissue biology in a mouse model of obesity
… of HF pregnant mice, gene pathways for de novo lipogenesis and lipid storage, inflammation, retinol metabolism, insulin like growth factor and estrogenic signaling showed altered regulation. Given the known role of estrogen on adipose tissue and inflammatory cell function, a hypothesis was …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… production, blood glucose and NEFA with rate of lipogenesis and lipolysis in adipose tissues of dairy cows differ for genetic merit (high genetic merit, HGM; low genetic merit, LGM). Adipose tissue biopsies were taken at -21, 7, 28 and 56 d around parturition. The mRNA expression of lipogenic …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… has been shown to disrupt glycolysis, de novo lipogenesis, and induce antitumor immunity. In our lab, we discovered another cancer-specific LXR inverse agonist, GAC0001E5 (1E5), in pancreatic ductal adenocarcinoma (PDAC). Treatment with 1E5 has been demonstrated to inhibit glutaminolysis and …
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Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells
… CoA carboxylase 1 (ACC1) is essential in de novo lipogenesis, which has been implicated in GSIS by other laboratories. Chronic, but not acute, inhibition of ACC1 via siRNA reduced insulin secretion independent of lipogenesis. ACC1 siRNA decreased glucose oxidation, pyruvate cycling, and ATP:ADP, …
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