Global ETD Search
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Showing 1 to 11 of 11 for “"lipocalin 2"”.
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ROLE OF LIPOCALIN 2 IN KAINATE-INDUCED NEURODEGENERATION
Lipocalin 2 (LCN2) is a member of the lipocalin family, which has diverse roles in infections, iron homeostasis, apoptosis, tumourigenesis, inflammation, renal physiology and pathology. Yet, little is known about the functions of LCN2 in the central nervous system (CNS). In view of recent studies …
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Lipocalin 2 Promotes The Establishment of A Pro-Tumorigenic Microenvironment In Pancreatic Cancer
<p>Pancreatic ductal adenocarcinoma (PDAC) is a disease characterized by a dismal prognosis with a 5-year survival rate of 7%. A unique hallmark of this disease is an abundant desmoplastic reaction that can account for up to 90% of the solid tumor volume. Key components of the PDAC stroma include …
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Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
Lipocalin-2 (LCN-2) ist eine pleiotrope 25-kDa sekretorischen Proteins, das derzeit als Biomarker für Nierenschäden und Entzündungen eingesetzt. Sein Serumspiegel unter verschiedenen pathologischen Bedingungen erhöht, aber die Quelle und Ursache sind unklar. Das Ziel unserer Studie war es, zur …
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Discovery and validation of novel blood biomarkers of breast and prostate cancer
… biomarker potential of five proteins: Serpin B1, Lipocalin 2, Copine 3, Integrin 4 and 5LOX, using Western blot, immunofluorescence, flow cytometry and ELISA techniques. Serpin B1, Lipocalin 2, 5LOX and Copine 3 were present in neutrophils, whereas Integrin 4 was detected in T-lymphocytes. …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… to identify and characterise the expression of lipocalin 2, a novel GC-responsive chondrocyte gene which may contribute to GC-induced growth retardation in the growth plate. In vitro and in vivo studies have also been used to examine the role of the cell cycle regulator, p21WAF1/CIP1 in …
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Obesity in Patients with Inflammatory Bowel Disease // Затлъстяване при пациенти с хронични възпалителни болести на червата
… hand, recently, circulating levels of human Lipocalin-2/NGAL have been successfully linked as a tool to monitor activity and response to treatment in patients with immune-mediated diseases. The absence of data combining the results of these new noninvasive markers in the study of patients …
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The molecular effects of low dose fractionated radiation treatment on Ovarian Adenocarcinoma
… element (ERE) and one of its target genes, Lipocalin 2, which is known to be involved in the growth and differentiation of cells, were not induced as a result of LDFRT, but induction was observed after treatment with a single dose of 2 Gy radiation. This observation indicates a possible …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
Neutrophil gelatinase-associated lipocalin (NGAL), also called lipocalin-2, is a secreted protein belonging to the lipocalin family proteins and actively participates into the proliferation, differentiation, and development of human tissues, including tumours. It positively modulates the activity …
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Role of the Gut Microbiome in Cancer Immunotherapy Efficacy and Side Effects
… lymphocytes. Histological assessment and lipocalin-2 measurement were used to evaluate anti-CTLA-4-induced gut inflammation. 16S rRNA sequencing identified specific bacterial taxa associated with gut toxicity (Dubosiella and genera from Lachnospiraceae) or protection (UBA7173 and …
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… mechanisms for the persistent induction of lipocalin 2 (LCN2) in response to 100 ng/mL of lipopolysaccharide (LPS) in kidney fibroblasts was examined. It appears that the intracellular signaling network responsible for the persistent induction of LCN2 requires both activator protein-1 (AP-1) …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… to reduce angiogenesis in breast cancer cells. Lipocalin 2 (Lcn2) is a promising therapeutic target for metastatic breast cancer (MBC) and triple negative breast cancer (TNBC). Lcn2 overexpression in breast cancer lead to its progression by inducing the epithelial to mesenchymal transition and …